Results 211 to 220 of about 155,866 (241)
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Transcription-Associated Genome Instability
Chemical Reviews, 2013Peer ...
Gaillard, Hélène +2 more
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2018
Genome instability: methods and protocols. , Genome instability: methods and protocols.
Muzi-Falconi, Brown, Grant W.
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Genome instability: methods and protocols. , Genome instability: methods and protocols.
Muzi-Falconi, Brown, Grant W.
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Science
Germline structural variants are a risk factor for pediatric extracranial solid ...
Jayne Y, Hehir-Kwa, Geoff, Macintyre
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Germline structural variants are a risk factor for pediatric extracranial solid ...
Jayne Y, Hehir-Kwa, Geoff, Macintyre
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Genomic Instability and Cancer
Current Molecular Medicine, 2003Tumorigenesis can be viewed as an imbalance between the mechanisms of cell-cycle control and mutation rates within the genes. Genomic instability is broadly classified into microsatellite instability (MIN) associated with mutator phenotype, and chromosome instability (CIN) recognized by gross chromosomal abnormalities.
George S, Charames, Bharati, Bapat
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Apoptosis and genomic instability
Nature Reviews Molecular Cell Biology, 2004Genomic instability is intrinsically linked to significant alterations in apoptosis control. Chromosomal and microsatellite instability can cause the inactivation of pro-apoptotic pathways. In addition, the inhibition of apoptosis itself can be permissive for the survival and ongoing division of cells that have failed to repair DNA double-strand breaks,
Boris, Zhivotovsky, Guido, Kroemer
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Genomic instability in neoplasia
Seminars in Cell Biology, 1995Recent studies have demonstrated novel alterations of microsatellite DNA in tumor tissue. The alterations, termed microsatellite instability or replication error phenotype, have now been observed in tumors from patients with hereditary nonpolyposis colorectal cancer (HNPCC), the Muir-Torre syndrome (MTS) and in an increasing number of sporadic tumors ...
R, Honchel, K C, Halling, S N, Thibodeau
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Annual Review of Genetics, 2013
Genomes are transmitted faithfully from dividing cells to their offspring. Changes that occur during DNA repair, chromosome duplication, and transmission or via recombination provide a natural source of genetic variation. They occur at low frequency because of the intrinsic variable nature of genomes, which we refer to as genome instability.
Andrés, Aguilera, Tatiana, García-Muse
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Genomes are transmitted faithfully from dividing cells to their offspring. Changes that occur during DNA repair, chromosome duplication, and transmission or via recombination provide a natural source of genetic variation. They occur at low frequency because of the intrinsic variable nature of genomes, which we refer to as genome instability.
Andrés, Aguilera, Tatiana, García-Muse
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Annual Review of Physiology, 2013
Genome instability has long been implicated as the main causal factor in aging. Somatic cells are continuously exposed to various sources of DNA damage, from reactive oxygen species to UV radiation to environmental mutagens. To cope with the tens of thousands of chemical lesions introduced into the genome of a typical cell each day, a complex network ...
Jan, Vijg, Yousin, Suh
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Genome instability has long been implicated as the main causal factor in aging. Somatic cells are continuously exposed to various sources of DNA damage, from reactive oxygen species to UV radiation to environmental mutagens. To cope with the tens of thousands of chemical lesions introduced into the genome of a typical cell each day, a complex network ...
Jan, Vijg, Yousin, Suh
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Genome instability and oncogenesis
Molecular Biology, 2007Molecular alterations leading to genetic instability play a key role in tumor development. The basic reasons of genetic instability of tumor cells, i.e. up-regulation of intracellular level of endogenous mutagens, in particular reactive oxygen spesies (ROS); decreased fidelity of DNA replication and chromosome segregation in mitosis; defects in DNA ...
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Combing the genome for genomic instability
Trends in Biotechnology, 2002Genomic instability is one of the major features of cancer cells. The clinical phenotypes associated with several human diseases have been linked to recurrent DNA rearrangements and dysfunction of DNA replication processes that involve unstable genomic regions.
Sandrine, Caburet +2 more
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