Results 221 to 230 of about 155,866 (241)
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Radiation-induced Genomic Instability
International Journal of Radiation Biology, 1994Quantitative assessment of the heritable somatic effects of ionizing radiation exposures has relied upon the assumption that radiation-induced lesions were 'fixed' in the DNA prior to the first postirradiation mitosis. Lesion conversion was thought to occur during the initial round of DNA replication or as a consequence of error-prone enzymatic ...
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Radiation-induced genomic instability
International Journal of Radiation Biology, 1998Purpose: This report reviews the data obtained in the author's laboratory over the past two decades, which support the hypothesis that radiation can induce a genome-wide process of instability in mammalian cells that is transmitted over many generations of cell replication leading to an enhanced frequency of genetic changes occurring among the progeny ...
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Early genome instability vs Late genome instability
This repository contains the data required to compare the mutational signatures and immune system of early/late genome instability tumours.openaire +1 more source
Genomic instability and radiation
Journal of Radiological Protection, 2003Genomic instability is a hallmark of cancer cells, and is thought to be involved in the process of carcinogenesis. Indeed, a number of rare genetic disorders associated with a predisposition to cancer are characterised by genomic instability occurring in somatic cells.
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Germline mutation and genome instability
European Journal of Cancer Prevention, 1999Colorectal tumorigenesis has been associated with the progressive acquisition of a variety of genomic alterations in neoplastic cells. In 5-10% of cases, a strong family history of cancer suggests a major predisposition, either familial adenomatous polyposis (FAP) or HNPCC syndrome.
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Molekuliarnaia biologiia, 1981
The paper deals with the various manifestations and the role of genome changes, mainly in eukaryotes. I. Hereditary changes: 1) multiplication of genes in animals; 2) multiplication of genes in prokaryotes; 3) microsymbionts, mobile elements and supermutability; 4) extrachromosomal element delta in Drosophila; 5) hybrid dysgenesis in Drosophila; 6 ...
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The paper deals with the various manifestations and the role of genome changes, mainly in eukaryotes. I. Hereditary changes: 1) multiplication of genes in animals; 2) multiplication of genes in prokaryotes; 3) microsymbionts, mobile elements and supermutability; 4) extrachromosomal element delta in Drosophila; 5) hybrid dysgenesis in Drosophila; 6 ...
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