Results 21 to 30 of about 294,348 (299)
Dicer prevents genome instability in response to replication stress [PDF]
, 2019 Dicer, an endoribonuclease best-known for its role in microRNA biogenesis and RNA interference pathway, has been shown to play a role in the DNA damage response and repair of double-stranded DNA breaks (DSBs) in mammalian cells.
Barra, Viviana +6 more
core +2 more sources
ATR is required to complete meiotic recombination in mice
Nature Communications, 2018 ATR kinase is required for meiosis in non-mammalian model organisms. Here the authors demonstrate, using a hypomorphic Atr mutation and chemical inhibition, that ATR is also essential for male meiosis in mouse, regulating meiotic recombination and ...
Sarai Pacheco +11 more
doaj +1 more source
Nature Communications, 2021 The tumour microenvironment (TME) may change in response to cancer treatments such as KRAS G12C inhibition, with potential implications for combination therapies. Here, the authors provide an antibody panel and workflow for analysing the TME with imaging
Febe van Maldegem +17 more
doaj +1 more source
Detection of DNA-RNA hybrids in vivo [PDF]
, 2017 DNA-RNA hybrids form naturally during essential cellular functions such as transcription and replication. However, they may be an important source of genome instability, a hallmark of cancer and genetic diseases.
Aguilera López, Andrés +2 more
core +1 more source
Meiotic chromosome dynamics and double strand break formation in reptiles
Frontiers in Cell and Developmental Biology, 2022 During meiotic prophase I, tightly regulated processes take place, from pairing and synapsis of homologous chromosomes to recombination, which are essential for the generation of genetically variable haploid gametes.
Laia Marín-Gual +11 more
doaj +1 more source
Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability [PDF]
, 2018 R loops are nucleic acid structures comprising an DNA-RNA hybrid and a displaced single-stranded DNA. These structures may occur transiently during transcription, playing essential biological functions. However, persistent R loops may become pathological
Aguilera López, Andrés +2 more
core +1 more source
Methylation of KRAS by SETD7 promotes KRAS degradation in non-small cell lung cancer
Cell Reports, 2023 Summary: Oncogenic KRAS mutations are a key driver for initiation and progression in non-small cell lung cancer (NSCLC). However, how post-translational modifications (PTMs) of KRAS, especially methylation, modify KRAS activity remain largely unclear ...
Cheng-Yao Chiang +11 more
doaj +1 more source
Genomic instability and the link to infertility: A focus on microsatellites and genomic instability syndromes [PDF]
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2022 Infertility is associated to multiple types of different genomic instabilities and is a genetic feature of genomic instability syndromes. While the mismatch repair machinery contributes to the maintenance of genome integrity, surprisingly its potential role in infertility is overlooked. Defects in mismatch repair mechanisms contribute to microsatellite
Wieland, Jack +3 more
openaire +3 more sources
Scientific Reports, 2018 DNA repeats constitute a large part of genomes of multicellular eucaryotes. For a longtime considered as junk DNA, their role in genome organization and tuning of gene expression is being increasingly documented.
Astrid Lancrey +2 more
doaj +1 more source
Tissue specificity in DNA repair: lessons from trinucleotide repeat instability. [PDF]
, 2014 DNA must constantly be repaired to maintain genome stability. Although it is clear that DNA repair reactions depend on cell type and developmental stage, we know surprisingly little about the mechanisms that underlie this tissue specificity. This is due,
Dion, V.
core +1 more source