Results 31 to 40 of about 294,348 (299)
MicroRNAs, Genomic Instability and Cancer [PDF]
International Journal of Molecular Sciences, 2014 MicroRNAs (miRNAs) are small non-coding RNA transcripts approximately 20 nucleotides in length that regulate expression of protein-coding genes via complementary binding mechanisms. The last decade has seen an exponential increase of publications on miRNAs, ranging from every aspect of basic cancer biology to diagnostic and therapeutic explorations ...
Vincent, Kimberly +3 more
openaire +3 more sources
RAS oncogenic activity predicts response to chemotherapy and outcome in lung adenocarcinoma
Nature Communications, 2022 Mutations in RAS oncogenes and related pathways are frequent in lung cancers. Here, the authors derive a RAS gene expression signature and a machine learning classifier to predict drug response and clinical outcomes in lung adenocarcinoma and other solid
Philip East +10 more
doaj +1 more source
Molecular Docking for the Development of Alternative Therapies against Leishmaniasis
Chemistry Proceedings, 2023 Topoisomerases play a pivotal role in regulating the topological structure of DNA during fundamental processes such as transcription, DNA repair, or DNA replication; because of this, topoisomerases are biological targets in pathogenic microorganisms or ...
Juan Diego Guarimata +3 more
doaj +1 more source
RNase H enables efficient repair of R-loop induced DNA damage. [PDF]
, 2016 R-loops, three-stranded structures that form when transcripts hybridize to chromosomal DNA, are potent agents of genome instability. This instability has been explained by the ability of R-loops to induce DNA damage. Here, we show that persistent R-loops
Amon, Jeremy D, Koshland, Douglas
core +1 more source
Escape from nonsense-mediated decay associates with anti-tumor immunogenicity
Nature Communications, 2020 The transcripts generated by frameshifts and indels in cancer are frequently degraded by nonsense mediated decay. Here, the authors show that some of these transcripts can escape this degradation mechanism and their prevalence correlates with tumour ...
Kevin Litchfield +19 more
doaj +1 more source
The DNA damage response acts as a safeguardagainst harmful DNA–RNA hybrids ofdifferent origins [PDF]
, 2019 Despite playing physiological roles in specific situations, DNA–RNA hybrids threat genome integrity. To investigate how cells do counteract spontaneous DNA–RNA hybrids, here we screen an siRNA library covering 240 human DNA damage response (DDR) genes ...
Aguilera López, Andrés +5 more
core +1 more source
Selective inhibition of cancer cell self-renewal through a Quisinostat-histone H1.0 axis
Nature Communications, 2020 Targeting self-renewing cancer cells without deleterious side effects in normal tissues has proven challenging. Here, the authors show that the well-tolerated HDAC inhibitor Quisinostat safely inhibits tumor maintenance and disease relapse by restoring ...
Cristina Morales Torres +16 more
doaj +1 more source
The Dynamic Instability of the Aneuploid Genome [PDF]
Frontiers in Cell and Developmental Biology, 2022 Proper partitioning of replicated sister chromatids at each mitosis is crucial for maintaining cell homeostasis. Errors in this process lead to aneuploidy, a condition in which daughter cells harbor genome imbalances. Importantly, aneuploid cells often experience DNA damage, which in turn could drive genome instability. This might be the product of DNA
Lorenza Garribba +2 more
openaire +4 more sources
Representative Sequencing: Unbiased Sampling of Solid Tumor Tissue
Cell Reports, 2020 Summary: Although thousands of solid tumors have been sequenced to date, a fundamental under-sampling bias is inherent in current methodologies. This is caused by a tissue sample input of fixed dimensions (e.g., 6 mm biopsy), which becomes grossly under ...
Kevin Litchfield +181 more
doaj +1 more source
Breaking barriers for glioblastoma with a path to enhanced drug delivery
Nature Communications, 2023 Progress in treatment for glioblastoma is hindered by the blood-brain barrier (BBB). In genetic mouse models recapitulating brain invasion and abnormal angiogenesis of human glioblastoma, Cai and colleagues demonstrate that optical modulation of the BBB ...
Imran Noorani, Jorge de la Rosa
doaj +1 more source