Results 151 to 160 of about 72,600 (260)

Genome mining strategies to unlock the metabolic potential of <i>Streptomyces</i> sp. VITGV100 (MCC 4961) for next-generation antimicrobial discovery. [PDF]

Front Microbiol
Pattapulavar V, Subburaj S, Ramanujam S, Shil R, Velmurugan P, Ghatak T, Muthusamy S, Samrot AV, Christopher JG.   +8 more
europepmc   +1 more source

Polyesterase activity and thermostability of carboxylesterases from Thermoleophilum album YS‐3

The FEBS Journal, EarlyView.
Three novel α/β‐hydrolases from thermophilic bacterium Thermoleophilum album display carboxylesterase and polyesterase activity. These enzymes hydrolyse PET, PLA and PCL both at high and moderate temperatures. TA21 shows superior activity, efficiently converting MHET to terephthalic acid. Structural features underlying substrate binding highlight their
Tatyana N. Chernikova, Anna N. Khusnutdinova, Hairong Ma, Manuel Ferrer, Olga V. Golyshina, Alexander F. Yakunin, Peter N. Golyshin   +6 more
wiley   +1 more source

Expanding the actinomycetes landscape for phosphonate natural products through genome mining. [PDF]

RSC Chem Biol
Zimmermann A, Xia SN, Moschny J, Gomez-Escribano JP, Boldt J, Nübel U, Nouioui I, Krause J, Irle MK, Metcalf WW, Hughes CC, Mast Y.   +11 more
europepmc   +1 more source

Investigating transthyretin variants H88R and I107V in amyloid priming: From destabilization to complete dissociation

The FEBS Journal, EarlyView.
Investigated mutations in transthyretin (TTR) disrupt the F87‐centered hydrophobic core that stabilizes its tetrameric structure. The mild I107V mutation weakens inter‐chain packing, while H88R fully abolishes tetramer formation, yielding a monomeric, aggregation‐prone form. Structural, biophysical, and computational analyses reveal that both mutations
István L. Bódy, Zsolt Fazekas, Nóra Wágner, Anna J. Kiss‐Szemán, Veronika Harmat, Zoltán Pozsonyi, Dóra K. Menyhárd, András Perczel   +7 more
wiley   +1 more source

Genome-mining revealed biosurfactant production capacity and gene co-occurrence patterns in diverse ecosystems. [PDF]

Microb Cell Fact
Ullah H, Selvarajan R, Lau Vetter MCY.
europepmc   +1 more source

Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health

The FEBS Journal, EarlyView.
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin, Sumit Bhutada, Suneel S. Apte   +2 more
wiley   +1 more source

Genome mining reveals the unique function of UbiA-type prenyltransferase in Laetiporus sulphureus. [PDF]

Nat Prod Bioprospect
Wang Y, Wang Q, Wang C, Wang P, Wang R, Wu J, Kawagishi H, Liu C.   +7 more
europepmc   +1 more source

Tyrosine residues at the substrate binding site in human NQO1 homodimer: Protein conformational dynamics and optimization of substrate binding geometry

The FEBS Journal, EarlyView.
Human NAD(P)H:quinone oxidoreductase 1 is a homodimeric flavoenzyme crucial for redox metabolism and linked to significant health issues. Point mutations at Tyr126 and Tyr128 demonstrate their essential roles in optimizing substrate binding geometry for catalysis, as well as in half‐site reactivity and conformational dynamics during the enzyme's ...
Maribel Rivero, Juan Luis Pacheco‐Garcia, Pavla Vankova, Dmitry Loginov, Isabel Quereda‐Moraleda, Jose Manuel Martin‐Garcia, Petr Man, Angel Luis Pey, Milagros Medina   +8 more
wiley   +1 more source

Genome Mining and Structural Study of Cathelicidins Across Chiroptera Species. [PDF]

Biochem Res Int
López MR, González-Almécija B, Farrais-Solana F, Otazo-Pérez A, González-Acosta S, Asensio-Calavia P, Morales-delaNuez A, Pérez de la Lastra JM.   +7 more
europepmc   +1 more source

Genetic and Ecological Management of Pacific Salmon Fisheries for the 21st Century

Fisheries Management and Ecology, EarlyView.
ABSTRACT Based on ecological adaptation theory, tremendous effort is being spent on measures that are eliminating salmon hatcheries and fishing opportunities with the intention of protecting wild runs deemed to be of particular genetic importance to the survival of the species.
Randall E. Brummett, Ian G. Cowx, Devin M. Bartley   +2 more
wiley   +1 more source