Results 161 to 170 of about 72,600 (260)

Biosynthesis and genome mining strategies for purine-derived <i>N</i>-nucleoside antibiotics. [PDF]

Front Microbiol
Wu Y, Wu S, Niu X, Yu X, Chen T, Liu G, Zhang W.   +6 more
europepmc   +1 more source

Performing Large‐Scale Genetic Analysis in the Bleeding Disorders Community

Haemophilia, EarlyView.
ABSTRACT Inherited bleeding disorders encompass a diverse group of conditions caused by genetic defects affecting coagulation factors, fibrinogen, von Willebrand factor, or platelet function. Despite major advances in quantitative and functional laboratory assays, a substantial diagnostic gap remains, particularly in patients with mild or atypical ...
Anna R. Blankstein, Sterre P. E. Willems, Saskia E. M. Schols, Rosanna Asselta, Gillian Lowe, Neil V. Morgan, Paula D. James   +6 more
wiley   +1 more source

Lipid-donor-anchored genome mining uncovers dioxanopeptins, antibacterial lipopeptides with a 1,3-dioxane functionalized polyunsaturated lipid tail. [PDF]

Chem Sci
Chen Y, Chen Y, Xiang H, Luo C, Duan J, Hu K, Zheng X, Liu J, Xue Y, Shi YM.   +9 more
europepmc   +1 more source

Breeding 5.0: Artificial intelligence (AI)‐decoded germplasm for accelerated crop innovation

Journal of Integrative Plant Biology, EarlyView.
ABSTRACT Crop breeding technologies are vital for global food security. While traditional methods have improved yield, stress tolerance, and nutrition, rising challenges such as climate instability, land loss, and pest pressure now demand new solutions.
Jiayi Fu, Shouzhi Zheng, Longjiang Fan, Xiaoming Zheng, Qian Qian   +4 more
wiley   +1 more source

Discovery of Suomilide and Cyanopeptolin Analogues by ¹⁵N Stable Isotope Labeling and Genome Mining of Cyanobacteria. [PDF]

J Nat Prod
Chauvin IM, Davis LJ, Krunic A, Orjala J.   +3 more
europepmc   +1 more source

Drivers of strigolactone diversity: P450s in strigolactone biosynthesis

Journal of Integrative Plant Biology, Volume 68, Issue 6, Page 1635-1652, June 2026.
This review summarizes the discovery and functional identification of cytochrome P450 in strigolactone biosynthesis, classifies and summarizes the members discovered so far, clarifies their biological significance, discusses the technology of strigolactone synthesis research, and finally describes some problems in strigolactone research and potential ...
Changbin Niu, Harro J. Bouwmeester, Changsheng Li   +2 more
wiley   +1 more source

Genome Mining of Isoindolinone-Containing Peptide Natural Products. [PDF]

J Am Chem Soc
Zhang Y, Wu L, Wang Z, Han W, Kerr TA, Tang Y.   +5 more
europepmc   +1 more source

A leucine‐rich‐repeat receptor‐like kinase SERL1 phosphorylates and stabilizes OsALDH2B1 to promote alkaline tolerance and grain size in rice

Journal of Integrative Plant Biology, EarlyView.
The rice aldehyde dehydrogenase OsALDH2B1 enhances grain size and tolerance to alkaline soil by repressing GRAIN SIZE 3 and activating catalases. SERL1‐mediated phosphorylation stabilizes OsALDH2B1 under stress, establishing a signaling axis that overcomes growth‐defense trade‐offs and provides a direct target for breeding high‐yield, alkaline ...
Zemin Ma, Xuanlin Gao, Shuaizu An, Mengyuan Chen, Biaoming Zhang, Lei Zhou, Shengyuan Sun, Ming Li, Feng Yu, Shiyou Lü, Zhaohui Chu, Aiqing You, Yinggen Ke, Pingfang Yang   +13 more
wiley   +1 more source

Untargeted metabolomic profiling and genome mining of endophytic <i>Stenotrophomonas maltophilia</i> strain 3A reveal a rich source of bioactive secondary metabolites. [PDF]

Front Microbiol
Sahu PK, Dhal KN, Kale N, Gupta A, Rai N, Singla D, Srivastava AK.   +6 more
europepmc   +1 more source

Constitution and function of intergenic genome regions in cultivated versus annual wild soybean in China

Journal of Integrative Plant Biology, EarlyView.
Three‐case restricted two‐stage multi‐locus multi‐allele genome‐wide association study identified main‐effect genes and detected the regulatory effects of intergenic loci on genes, enabling comprehensive dissection of the genic‐intergenic genetic system for quantitative traits and providing a strategy for studying their genetic basis.
Xiaoshuai Hao, Xinyang Hu, Yongpeng Pan, Qi Zhang, Ran Ou, Fenfen Jiang, Fangdong Liu, Jiaoping Zhang, Wubin Wang, Guangnan Xing, Junyi Gai, Jianbo He   +11 more
wiley   +1 more source