Results 191 to 200 of about 80,905 (306)

New perspectives on VEGF signalling in Alzheimer's disease

Brain Pathology, EarlyView.
Emery et al. bring together findings from recent multi‐omic studies, including single‐cell mRNA analysis of human post‐mortem brain tissue, and proteomic analysis of matched CSF and blood samples in large clinical studies. The authors present evidence of the involvement of altered VEGF signalling in vascular and immune dysfunction and neurodegeneration
Cherelle E. G. Emery, Seth Love, J. Scott Miners   +2 more
wiley   +1 more source

Genome Mining of Deep-Sea Cold Seep-Derived Fungus Reveals a Laccase-Fasciclin System Modulating Regioselective Naphthopyranone Dimerization. [PDF]

Int J Mol Sci
Li H, Li Z, Sun J, Yang X, Xing K, Shi M, Xiao F, Li W.   +7 more
europepmc   +1 more source

Genome Mining Approaches for the Discovery of Novel Lasso Peptides

, 2014
Lasso peptides are a class of ribosomally-synthesized, post-translationally modified natural products made by a variety of species of bacteria. They are characterized by an extraordinarily stable slipknot-like structure, which, along with their diverse ...
Wu, Michelle
core  

Conservation implications of low contemporary connectivity along the Mid‐Atlantic Ridge in hydrothermal vent gastropods

Conservation Biology, EarlyView.
Abstract Polymetallic sulfide deposits produced at hydrothermal vent fields are targets for mining exploitation along the Mid‐Atlantic Ridge, threatening the functioning and resilience of vent ecosystems that provide multiple ecosystem services. Knowledge about connectivity between vents will inform conservation practices.
E. Portanier, A. Tran Lu Y, F. Pradillon, C. Daguin‐Thiébaut, S. Ruault, P. Collins, E. Omnes, S. Fuchs, J. Carlsson, D. Jollivet, M. Matabos   +10 more
wiley   +1 more source

An Antifungal with a Novel Mechanism of Action Discovered via Resistance Gene-Guided Genome Mining. [PDF]

ACS Cent Sci
Perlatti B, Vellanki S, Zhang Y, Chiang YM, Hu Y, Yuan M, Dunbar K, Fine A, Grau MF, Li S, O'Donnell T, Shenoy R, Li H, Shi H, Xu X, Chen Z, Arvedson T, Tang Y, Cramer RA, Cee V, Harvey CJB.   +20 more
europepmc   +1 more source

The Role of SAMHD1 in Viral Resistance and Transduction Efficiency Challenges in Pediatric Hematological Malignancies: Mechanistic Insights and Clinical Perspectives

European Journal of Haematology, EarlyView.
SAMHD1 regulates intracellular dNTP pools, influencing lentiviral transduction, gene therapy efficiency, and disease progression in pediatric hematological malignancies. Integrated bioinformatics and targeted strategies, including CRISPR and pharmacological inhibition, highlight its therapeutic potential.
Waseem Alzamzami
wiley   +1 more source

Polyesterase activity and thermostability of carboxylesterases from Thermoleophilum album YS‐3

The FEBS Journal, EarlyView.
Three novel α/β‐hydrolases from thermophilic bacterium Thermoleophilum album display carboxylesterase and polyesterase activity. These enzymes hydrolyse PET, PLA and PCL both at high and moderate temperatures. TA21 shows superior activity, efficiently converting MHET to terephthalic acid. Structural features underlying substrate binding highlight their
Tatyana N. Chernikova, Anna N. Khusnutdinova, Hairong Ma, Manuel Ferrer, Olga V. Golyshina, Alexander F. Yakunin, Peter N. Golyshin   +6 more
wiley   +1 more source

Genome mining strategies to unlock the metabolic potential of <i>Streptomyces</i> sp. VITGV100 (MCC 4961) for next-generation antimicrobial discovery. [PDF]

Front Microbiol
Pattapulavar V, Subburaj S, Ramanujam S, Shil R, Velmurugan P, Ghatak T, Muthusamy S, Samrot AV, Christopher JG.   +8 more
europepmc   +1 more source

Investigating transthyretin variants H88R and I107V in amyloid priming: From destabilization to complete dissociation

The FEBS Journal, EarlyView.
Investigated mutations in transthyretin (TTR) disrupt the F87‐centered hydrophobic core that stabilizes its tetrameric structure. The mild I107V mutation weakens inter‐chain packing, while H88R fully abolishes tetramer formation, yielding a monomeric, aggregation‐prone form. Structural, biophysical, and computational analyses reveal that both mutations
István L. Bódy, Zsolt Fazekas, Nóra Wágner, Anna J. Kiss‐Szemán, Veronika Harmat, Zoltán Pozsonyi, Dóra K. Menyhárd, András Perczel   +7 more
wiley   +1 more source

Expanding the actinomycetes landscape for phosphonate natural products through genome mining. [PDF]

RSC Chem Biol
Zimmermann A, Xia SN, Moschny J, Gomez-Escribano JP, Boldt J, Nübel U, Nouioui I, Krause J, Irle MK, Metcalf WW, Hughes CC, Mast Y.   +11 more
europepmc   +1 more source