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Genome mining and prospects for antibiotic discovery
Current Opinion in Microbiology, 2019Natural products are a rich source of bioactive compounds that have been used successfully in the areas of human health from infectious disease to cancer; however, traditional fermentation-based screening has provided diminishing returns over the last 20-30 years.
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Genome mining and in vivo characterization of triceptides
Triceptides are cyclophane-containing ribosomally synthesized and post-translationally modified peptides (RiPPs) produced by bacteria. The class defining three-residue cyclophane is installed post-translationally by radical SAM enzymes (triceptide synthases) between the aromatic ring of Ω1 and the Cβ of X3 on Ω1-X2-X3 motifs.Andrew J Y, Yeo, Brandon I, Morinaka
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Genome mining for new enediyne antibiotics
Current Opinion in Chemical BiologyEnediyne antibiotics epitomize nature's chemical creativity. They contain intricate molecular architectures that are coupled with potent biological activities involving double-stranded DNA scission. The recent explosion in microbial genome sequences has revealed a large reservoir of novel enediynes. However, while hundreds of enediyne biosynthetic gene
Esther J. Han +1 more
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Proceedings of the National Academy of Sciences of the United States of America, 2023
Yi-Ming Chiang, Colin James Bell Harvey
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Yi-Ming Chiang, Colin James Bell Harvey
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antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline
Nucleic Acids Research, 2019Marnix H Medema +2 more
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