Results 271 to 280 of about 80,951 (303)

Mining the Mammalian Genome for Artiodactyl Systematics

Systematic Biology, 2001
A total of 7,806 nucleotide positions derived from one mitochondrial and eight nuclear DNA segments were used to provide a robust phylogeny for members of the order Artiodactyla. Twenty-four artiodactyl and two cetacean species were included, and the horse (order Perissodactyla) was used as the outgroup.
C A, Matthee, J D, Burzlaff, J F, Taylor, S K, Davis   +3 more
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Mining the Genome for Drugs

Science, 1999
SCIENCE AND BUSINESSPartly because of its early association with The Institute for Genomic Research, a company started by researchers who had devised an efficient way of finding genes, Human Genome Sciences Inc. of Rockville, Maryland, has a leg up on other biotech companies in current efforts to use modern genomics to find and develop new protein ...
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Mining genomes and ‘metagenomes’ for novel catalysts

Current Opinion in Biotechnology, 2005
Advances in the field of genomics and 'metagenomics' have dramatically revised our view of microbial biodiversity and its potential for biotechnological applications. Considering the estimation that >99% of microorganisms in most environments are not amenable to culturing, very little is known about their genomes, genes and encoded enzymatic activities.
Manuel, Ferrer, Francisco, Martínez-Abarca, Peter N, Golyshin   +2 more
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Using Proteomics to Mine Genome Sequences

Journal of Proteome Research, 2004
We present a method for mining unannotated or annotated genome sequences with proteomic data to identify open reading frames. The region of a genome coding for a protein sequence is identified by using information from the analysis of proteins and peptides with MALDI-TOF mass spectrometry.
Jonathan W, Arthur, Marc R, Wilkins
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Mining bacterial genomes for antimicrobial targets

Molecular Medicine Today, 2000
The elucidation of whole-genome sequences is expected to have a revolutionary impact on the discovery of novel medicines. With the availability of complete genome sequences of more than 30 different species, the field of antimicrobial drug discovery has the opportunity to access a remarkable diversity of genomic information. In this review, I summarize
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The Genomic Data Mine

2006
The genomic data mine represents a fundamental shift from genetics to genomics, essentially from the study of one gene at a time to the study of entire genetic metabolic networks and whole genomes. Experimental laboratory data are deposited into large public repositories and a wealth of computational data mining algorithms and tools are applied to mine
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Antimicrobials, drug discovery, and genome mining

Applied Microbiology and Biotechnology, 2012
Over the years, antibiotics have provided an effective treatment for a number of microbial diseases. However recently, there has been an increase in resistant microorganisms that have adapted to our current antibiotics. One of the most dangerous pathogens is methicillin-resistant Staphylococcus aureus (MRSA).
R J, Scheffler, S, Colmer, H, Tynan, A L, Demain, V P, Gullo   +4 more
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Repeats in genomic DNA: mining and meaning

Current Opinion in Structural Biology, 1998
For hundreds of millions of years, perhaps from the very beginning of their evolutionary history, eukaryotic cells have been habitats and junkyards for countless generations of transposable elements, preserved in repetitive DNA sequences. Analysis of these sequences, combined with experimental research, reveals a history of complex 'intracellular ...
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Text mining in genomics and systems biology

Proceedings of the 2nd international workshop on Data and text mining in bioinformatics, 2008
There is an increasing need of complementing the information available for the analysis of biological systems in Systems Biology and Genomics projects. A need that makes interesting the integration of information directly extracted from textual sources using Information Extraction and Text Mining approaches. My group has been working in developing Text
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Genome mining with hypothetical proteins

Natural products are diverse compounds made by many organisms, though bacteria, fungi, and plants are particularly prolific producers. While they have a range of biological roles, bioactive natural products have long been of interest as drug candidates.
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