Results 251 to 260 of about 80,951 (303)

Tyrosine residues at the substrate binding site in human NQO1 homodimer: Protein conformational dynamics and optimization of substrate binding geometry

The FEBS Journal, EarlyView.
Human NAD(P)H:quinone oxidoreductase 1 is a homodimeric flavoenzyme crucial for redox metabolism and linked to significant health issues. Point mutations at Tyr126 and Tyr128 demonstrate their essential roles in optimizing substrate binding geometry for catalysis, as well as in half‐site reactivity and conformational dynamics during the enzyme's ...
Maribel Rivero, Juan Luis Pacheco‐Garcia, Pavla Vankova, Dmitry Loginov, Isabel Quereda‐Moraleda, Jose Manuel Martin‐Garcia, Petr Man, Angel Luis Pey, Milagros Medina   +8 more
wiley   +1 more source

Genome Mining of Terpene Synthases from Fourteen <i>Streptomyces</i> Strains. [PDF]

Microorganisms
Li Y, Xiang X, Ren Z, Wang R, Xie M, Li G, Yan X, Zhao Z, Deng Z, Xu M, Hou A.   +10 more
europepmc   +1 more source

Performing Large‐Scale Genetic Analysis in the Bleeding Disorders Community

Haemophilia, EarlyView.
ABSTRACT Inherited bleeding disorders encompass a diverse group of conditions caused by genetic defects affecting coagulation factors, fibrinogen, von Willebrand factor, or platelet function. Despite major advances in quantitative and functional laboratory assays, a substantial diagnostic gap remains, particularly in patients with mild or atypical ...
Anna R. Blankstein, Sterre P. E. Willems, Saskia E. M. Schols, Rosanna Asselta, Gillian Lowe, Neil V. Morgan, Paula D. James   +6 more
wiley   +1 more source

Targeted genome mining with GATOR-GC maps the evolutionary landscape of biosynthetic diversity. [PDF]

Nucleic Acids Res
Cediel-Becerra JDD, Cumsille A, Guerra S, Ding Y, de Crécy-Lagard V, Chevrette MG.   +5 more
europepmc   +1 more source

From biology to biotechnology: Host‐regulation factors from parasitoid wasps are a source of bioactive molecules with translational potential

Insect Molecular Biology, EarlyView.
Parasitoid wasps deploy maternal and embryonic factors to reprogramme host physiology. Venom, calyx fluid, polydnaviruses, teratocytes and larval secretions act in a coordinated, compartmentalised manner. Host‐regulation factors are promising sources of insecticidal, antimicrobial and bioinspired translational molecules.
Ciro Pedro G. Pinto, Andrew A. Walker, Glenn F. King   +2 more
wiley   +1 more source

Genome mining for the discovery of peptide halogenases and their biochemical characterization. [PDF]

Methods Enzymol
Saha N, Agarwal V.
europepmc   +1 more source

Dietary modulation of antimicrobial peptides (HAMP and LEAP2) in Chinook salmon (Oncorhynchus tshawytscha) fed a phytobiotic functional diet: Integrated genomic characterisation and tissue‐specific expression

Journal of Fish Biology, EarlyView.
Abstract Antimicrobial peptides (AMPs) are key components of the innate immune system in fish, providing rapid protection against microbial pathogens. Among these, the liver‐expressed antimicrobial peptides (LEAPs), comprising LEAP‐1 (hepcidin; HAMP) and LEAP‐2, play central roles in host defence and iron regulation.
Roberta Marcoli, Jane E. Symonds, Seumas P. Walker, Cesar Lopez, Mark A. Preece, Christopher Battershill, Steve Bird   +6 more
wiley   +1 more source

Discovery and Biosynthesis of Nyuzenamides D and E by Genome Mining in <i>Streptomyces hygroscopicus</i>. [PDF]

ACS Omega
Lum KY, Kumar R, Yang Z, Souza LDO, Jarmusch SA, Moreira JMA, Morth JP, Ding L.   +7 more
europepmc   +1 more source

Genome Mining Reveals a Novel Nephthenol-Producing Diterpene Synthase from the Sandfly Lutzomyia Longipalpis. [PDF]

Chembiochem
Ducker C, McKeown C, Da Silva IFP, Souza IT, Pickett JA, Santana AEG, Oldham NJ.   +6 more
europepmc   +1 more source

Genome Mining Reveals Pathways for Terpene Production in Aerobic Endospore-Forming Bacteria Isolated from Brazilian Soils. [PDF]

Microorganisms
Mesquita FA, Silva WMCD, Raiol T, Brigido MM, Almeida NF, Fuga B, Cavalcante DA, De-Souza MT.   +7 more
europepmc   +1 more source