Results 241 to 250 of about 80,951 (303)

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, EarlyView.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source

Toward the Bioremediation of Nylon Waste Materials: Genome Mining Leads to the Identification of a Thermostable Laurolactamase From Thermopolyspora flexuosa. [PDF]

ChemSusChem
Cleveland ME, Bunyat-Zada AR, Hoffman ER, Howe GW.   +3 more
europepmc   +1 more source

PLIN5 Protects Against Ang II‐Induced Podocyte Lipotoxicity by Interacting With FKBP8 and Preserving Lipid Droplet–Mitochondria Contact

Cell Proliferation, EarlyView.
PLIN5‐FKBP8 tethers lipid droplets to mitochondria to counteract Ang II‐induced lipotoxicity. ABSTRACT Chronic kidney disease (CKD) remains a major global health challenge. Angiotensin II (Ang II)‐induced lipotoxicity is an important contributor to podocyte injury.
Ping Wang, Wenjie Chen, Jingjing Ke, Hongtu Hu, Zhuan Peng, Yue Qi, Guohua Ding, Jijia Hu   +7 more
wiley   +1 more source

Genome Mining Reveals Rifamycin Biosynthesis in a Taklamakan Desert Actinomycete. [PDF]

Microorganisms
Luo X, Liu Z, Luo X, Xia Z, Wan C, Wang H, Zhang L.   +6 more
europepmc   +1 more source

The Role of SAMHD1 in Viral Resistance and Transduction Efficiency Challenges in Pediatric Hematological Malignancies: Mechanistic Insights and Clinical Perspectives

European Journal of Haematology, EarlyView.
SAMHD1 regulates intracellular dNTP pools, influencing lentiviral transduction, gene therapy efficiency, and disease progression in pediatric hematological malignancies. Integrated bioinformatics and targeted strategies, including CRISPR and pharmacological inhibition, highlight its therapeutic potential.
Waseem Alzamzami
wiley   +1 more source

Genome-Mining Based Discovery of Pyrrolomycin K and L from the Termite-Associated <i>Micromonospora</i> sp. RB23. [PDF]

J Nat Prod
Lin M, de Kruijff M, Poulsen M, Beemelmanns C.   +3 more
europepmc   +1 more source

Polyesterase activity and thermostability of carboxylesterases from Thermoleophilum album YS‐3

The FEBS Journal, EarlyView.
Three novel α/β‐hydrolases from thermophilic bacterium Thermoleophilum album display carboxylesterase and polyesterase activity. These enzymes hydrolyse PET, PLA and PCL both at high and moderate temperatures. TA21 shows superior activity, efficiently converting MHET to terephthalic acid. Structural features underlying substrate binding highlight their
Tatyana N. Chernikova, Anna N. Khusnutdinova, Hairong Ma, Manuel Ferrer, Olga V. Golyshina, Alexander F. Yakunin, Peter N. Golyshin   +6 more
wiley   +1 more source

Discovery and expression of insecticidal proteins via genome mining of novel <i>Bacillus thuringiensis</i> strain Bt1Fo. [PDF]

Front Microbiol
Kobilov FB, Li P, Nazirov MM, Chen M, Miralimova S, Yakubov I, Asrorov AM, Sohibnazarova K, Azimova N, Khalilov I, Yusupov U, Chen Y, Tang Y, Mirakbarova Z.   +13 more
europepmc   +1 more source

Investigating transthyretin variants H88R and I107V in amyloid priming: From destabilization to complete dissociation

The FEBS Journal, EarlyView.
Investigated mutations in transthyretin (TTR) disrupt the F87‐centered hydrophobic core that stabilizes its tetrameric structure. The mild I107V mutation weakens inter‐chain packing, while H88R fully abolishes tetramer formation, yielding a monomeric, aggregation‐prone form. Structural, biophysical, and computational analyses reveal that both mutations
István L. Bódy, Zsolt Fazekas, Nóra Wágner, Anna J. Kiss‐Szemán, Veronika Harmat, Zoltán Pozsonyi, Dóra K. Menyhárd, András Perczel   +7 more
wiley   +1 more source

Genome Mining of <i>Cronobacter sakazakii</i> in Bangladesh Reveals the Occurrence of High-Risk ST83 and Rare ST789 Lineages. [PDF]

Pathogens
Bhowmik S, Rivu S, Bari ML, Ahmed S.
europepmc   +1 more source