Identification of PPFIA3 as a Potential Prognostic and Immune Biomarker Through Pan‐Cancer Analysis
Organ Medicine, EarlyView.This study reveals a significant increase in the expression of PPFIA3 across various cancers, which is associated with poor prognosis. Notably, in patients receiving anti‐PD‐L1 treatment, high PPFIA3 expression is closely linked to improved survival rates and favorable prognosis, suggesting its potential as a predictive factor for immune checkpoint ...
Xianghong Wang +4 more
wiley +1 more source
The significance of PAX5 in Merkel cell carcinoma
The Journal of Pathology, Volume 266, Issue 1, Page 81-94, May 2025.Abstract Merkel cell carcinoma (MCC) is a highly malignant skin cancer that expresses epithelial‐, neuroendocrine‐, and lymphoid‐associated genes. Here, we focused on B‐cell differentiation, which is characterised by the coexpression of PAX5 and TdT. PAX5 is the master regulator of B‐cell commitment and is expressed in 65% of MCC cases.
Emil Chteinberg +16 more
wiley +1 more source
Genome mining of labdane-related diterpenoids: Discovery of the two-enzyme pathway leading to (-)-sandaracopimaradiene in the fungus Arthrinium sacchari. [PDF]
Beilstein J Org ChemSato F +6 more
europepmc +1 more source
A Non‐Metaproteomics Researchers’ View on Metaproteomics in Microbiome Research
PROTEOMICS, EarlyView.ABSTRACT Metaproteomics, an emerging field among the omic techniques, holds great promise for unraveling the function of microbiomes in host health and our environment. Metaproteomics can also be a valuable addition to multiomics studies of the microbiome, complementing genome‐resolved metagenomics, metatranscriptomics, and metabolomics.
Velma T. E. Aho +5 more
wiley +1 more source
Sí se puede: The enduring legacy of Mexico on wine and politics
PLANTS, PEOPLE, PLANET, Volume 7, Issue 3, Page 514-523, May 2025.The cultural significance of the grapevine is undeniable. However, we fail to acknowledge how the grapevine has and continues to influence the most pressing political questions of our time. From the beginning of the Conquest, Indigenous peoples were forced to plant the vine, Spain burned the vines Miguel Hidalgo used to teach the poor, and César Chávez
Daniel H. Chitwood +6 more
wiley +1 more source
Interactions of rare earth elements with living organisms and emerging biotechnical applications
PLANTS, PEOPLE, PLANET, EarlyView.Rare earth elements (REEs) are critical resources required to achieve net‐zero carbon emission targets and energy security. However, rising demand for REEs coupled with significant extraction and processing challenges and geopolitical risks restricts access to REE resources.
Samantha A. McGaughey +6 more
wiley +1 more source
New investigation of encoding secondary metabolites gene by genome mining of a marine bacterium, Pseudoalteromonas viridis BBR56. [PDF]
BMC GenomicsHandayani DP, Isnansetyo A, Istiqomah I.
europepmc +1 more source
Scaling the grape berry developmental stage by molecular phenology: Application details and caveats
PLANTS, PEOPLE, PLANET, EarlyView.Global climate change is adversely affecting grape quality by accelerating developmental processes. We developed an advanced method to define grape berry phenological stages based on gene expression information and made it accessible for widespread research.
Giovanni Battista Tornielli +8 more
wiley +1 more source
Structure Prediction and Genome Mining-Aided Discovery of the Bacterial C-Terminal Tryptophan Prenyltransferase PalQ. [PDF]
Adv Sci (Weinh)Miyata A, Ito S, Fujinami D.
europepmc +1 more source
Placing Nothophylica piloburmensis from Cretaceous amber into the angiosperm phylogeny
TAXON, EarlyView.Abstract Recently, we redescribed an amber inclusion from mid‐Cretaceous Kachin amber of Myanmar, previously assigned to the extant genus Phylica in Rhamnaceae (core eudicots), and placed it in a new fossil‐genus, Nothophylica. Based on our reconstructions, we identified new floral features and instead suggested affinities within magnoliids, especially
Simon Beurel +4 more
wiley +1 more source