Results 121 to 130 of about 5,189,630 (339)

On the evolution of chromosomal regions with high gene strand bias in bacteria

mBio
On circular bacterial chromosomes, the majority of genes are coded on the leading strand. This gene strand bias (GSB) ranges from up to 85% in some Bacillota to a little more than 50% in other phyla.
Jürgen Tomasch, Karel Kopejtka, Sahana Shivaramu, Izabela Mujakić, Michal Koblížek   +4 more
doaj   +1 more source

Genome-wide identification and organization of seed storage protein genes of Cannabis sativa

Biologia Plantarum, 2018
Hemp (Cannabis sativa L.) seeds have been recognized as a nutritional protein source for humans and animals. In this study, gene families encoding precursor polypeptides of three storage protein classes, including six 11S edestin, two 2S albumin and one ...
E. Ponzoni, I. M. Brambilla, I. Galasso
doaj   +1 more source

FISH mapping and molecular organization of the major repetitive sequences of tomato [PDF]

, 2008
This paper presents a bird's-eye view of the major repeats and chromatin types of tomato. Using fluorescence in-situ hybridization (FISH) with Cot-1, Cot-10 and Cot-100 DNA as probes we mapped repetitive sequences of different complexity on pachytene ...
Chang, S.B., Datema, E., Jacobsen, E., Jong, J.H.S.G.M., de, Klein Lankhorst, R.M., Kuipers, A., Meznikova, M., Szinay, D., Vosman, B., Vugt, J., van, Yang, T.J.   +10 more
core   +2 more sources

Mapping 3D genome organization relative to nuclear compartments using TSA-Seq as a cytological ruler

Journal of Cell Biology, 2018
While nuclear compartmentalization is an essential feature of three-dimensional genome organization, no genomic method exists for measuring chromosome distances to defined nuclear structures.
Yu Chen, Yang Zhang, Yuchuan Wang, Liguo Zhang, E. Brinkman, S. Adam, R. Goldman, B. van Steensel, Jian Ma, A. Belmont   +9 more
semanticscholar   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Observing copepods through a genomic lens

Frontiers in Zoology, 2011
Background Copepods outnumber every other multicellular animal group. They are critical components of the world's freshwater and marine ecosystems, sensitive indicators of local and global climate change, key ecosystem service providers, parasites and ...
Johnson Stewart C, Goetze Erica, Frisch Dagmar, Bron James E, Lee Carol, Wyngaard Grace A   +5 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Ploidy Level and Genome Size of Vincetoxicum nigrum and V.rossicum (Apocynaceae), Two Invasive Vines in North Americ [PDF]

, 2011
Vincetoxicum nigrum (L.) Moench (black swallow-wort) and V. rossicum (Kleopow) Barbarich (pale swallow-wort) (Apocynaceae) are perennial vines that are targeted for classical biological control as a result of their massive invasion in natural areas and ...
Bakry, Frédéric, Bon, Marie-Claude, Bourge, Mickael, Darbyshire, S., Dolgovskaya, M., Guermache, Fathia, Milbrath, L., Rodier-Goud, Marguerite, Sforza, René, Volkovitsh, M.   +9 more
core  

Gene clusters reflecting macrodomain structure respond to nucleoid perturbations

, 2010
Focusing on the DNA-bridging nucleoid proteins Fis and H-NS, and integrating several independent experimental and bioinformatic data sources, we investigate the links between chromosomal spatial organization and global transcriptional regulation.
Alberts, Ashburner, Babu, Ball, Beloin, Berger, Bertin, Bianca Sclavi, Blot, Boccard, Bradley, Bruno Bassetti, Cabrera, Cabrera, Cases, Chilcott, Cho, Cho, Cook, Cunha, Cunha, Dame, Darling, Dillon, Dorman, Duan, Eisen, Esnault, Espéli, Espéli, Fang, Gama-Castro, Grainger, Hengen, Hengge, Janga, Jeong, Jin, Junier, Kahramanoglou, Kalir, Kalir, Kelly, Keseler, Ko, Korea, Krin, Képès, Képès, Lang, Liu, Luijsterburg, Marco Cosentino Lagomarsino, Marr, Mathelier, Mercier, Moulin, Muskhelishvili, Nielsen, Oberto, Ogasawara, Oshima, Pesavento, Peter, Postow, Prigent-Combaret, Prüss, Reyes-Lamothe, Rocha, Saldana, Serres, Smith, Sonnenschein, Soutourina, Soutourina, Soutourina, Travers, Valens, Vittore F. Scolari, Vora, Wade, Wang, Wang, Wang, Warren, Weber, Wiggins, Wright, Zechiedrich, Zimmerman   +89 more
core   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source