Results 131 to 140 of about 3,886,811 (311)

A genome-wide nucleosome-resolution map of promoter-centered interactions in human cells corroborates the enhancer-promoter looping model

eLife
The enhancer-promoter looping model, in which enhancers activate their target genes via physical contact, has long dominated the field of gene regulation.
Arkadiy K Golov, Alexey A Gavrilov, Noam Kaplan, Sergey V Razin   +3 more
doaj   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Simulation and Quantitative Analysis of Spatial Centromere Distribution Patterns

Cells
A prominent feature of eukaryotic chromosomes are centromeres, which are specialized regions of repetitive DNA required for faithful chromosome segregation during cell division.
Adib Keikhosravi, Krishnendu Guin, Gianluca Pegoraro, Tom Misteli   +3 more
doaj   +1 more source

Canonical nucleosome organization at promoters forms during genome activation.

, 2014
The organization of nucleosomes influences transcriptional activity by controlling accessibility of DNA binding proteins to the genome. Genome-wide nucleosome binding profiles have identified a canonical nucleosome organization at gene promoters, where ...
van Hummelen, Paul, Liu, X. Shirley, Fu, Kai, Wang, Chenfei, Liu, X., Feng, J., Ge, Y., Feng, Jianxing, Schier, Alexander F., Vastenhouw, Nadine L., Zhang, Y., Ge, Ying, Pauli, Andrea, Wang, C., Hummelen, P., Schier, A., Fu, K., Vastenhouw, N., Zhang, Yong   +18 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

RNA Pol II-based regulations of chromosome folding

Cell Genomics
Summary: The spatial organization of eukaryotic genomes and its dynamics are of functional importance for gene expression, DNA replication, and segregation.
Christophe Chapard, Nathalie Bastié, Axel Cournac, Laura Chaptal, Henri Mboumba, Sophie Queille, Agnes Thierry, Olivier Gadal, Armelle Lengronne, Romain Koszul, Frédéric Beckouët   +10 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

A diverse satellite DNA repertoire in Limnoperna fortunei: insights into genome structure and chromosomal organization

Frontiers in Molecular Biosciences
BackgroundThe Golden Mussel, Limnoperna fortunei, represents one of the most successful aquatic invaders in South America, causing significant ecological and economic impacts.
Jonathan Pena Castro, Tiago Marafiga Degrandi, Allan Oliveira Leal, Augusto Luiz Ferreira Júnior, Mara Cristina de Almeida, Roberto Ferreira Artoni, Roberto Ferreira Artoni   +6 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Editorial: Chromatin architecture in gene regulation and disease

Frontiers in Genetics, 2023
Xiang Wang
doaj   +1 more source