Results 11 to 20 of about 707,938 (218)
Deciphering Signatures of Mutational Processes Operative in Human Cancer
Cell Reports, 2013 The genome of a cancer cell carries somatic mutations that are the cumulative consequences of the DNA damage and repair processes operative during the cellular lineage between the fertilized egg and the cancer cell. Remarkably, these mutational processes
Ludmil B. Alexandrov +4 more
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Virulence, 2021 Hungatella hathewayi has been observed to be a member of the gut microbiome. Unfortunately, little is known about this organism in spite of being associated with human fatalities; it is important to understand virulence mechanisms and epidemiological ...
Laura E. Hernández-Juárez +7 more
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Mutational signatures of ionizing radiation in second malignancies
Nature Communications, 2016 Ionizing radiation may induce irreparable DNA damage leading to cancer. Here, the authors identify a specific signature of mutations arising in patients exposed to ionizing radiation and suggest that radiation-induced tumorigenesis is associated with ...
Sam Behjati +32 more
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Nature Communications, 2017 Osteosarcoma is a primary malignancy of bone that affects children and adults. Here, the authors sequence childhood and adult osteosarcomas, identifying mutations in insulin-like growth factor signalling genes and distinct genomic rearrangement profiles ...
Sam Behjati +32 more
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Direct Transcriptional Consequences of Somatic Mutation in Breast Cancer
Cell Reports, 2016 Disordered transcriptomes of cancer encompass direct effects of somatic mutation on transcription, coordinated secondary pathway alterations, and increased transcriptional noise.
Adam Shlien +36 more
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Systematic image‐driven analysis of the spatial Drosophila embryonic expression landscape
Molecular Systems Biology, 2010 Discovery of temporal and spatial patterns of gene expression is essential for understanding the regulatory networks and development in multicellular organisms.
Erwin Frise +2 more
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Salmonella enhances osteogenic differentiation in adipose-derived mesenchymal stem cells
Frontiers in Cell and Developmental Biology, 2023 The potential of mesenchymal stem cells (MSCs) for tissue repair and regeneration has garnered great attention. While MSCs are likely to interact with microbes at sites of tissue damage and inflammation, like in the gastrointestinal system, the ...
Nuradilla Mohamad-Fauzi +12 more
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The driver landscape of sporadic chordoma
Nature Communications, 2017 Chordoma is a rare often incurable malignant bone tumour. Here, the authors investigate driver mutations of sporadic chordoma in 104 cases, revealing duplications in notochordal transcription factor brachyury (T), PI3K signalling mutations, and mutations
Patrick S. Tarpey +31 more
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The Cancer Genome Anatomy Project: EST Sequencing and the Genetics of Cancer Progression
Neoplasia: An International Journal for Oncology Research, 1999 As the process of tumor progression proceeds from the normal cellular state to a preneoplastic condition and finally to the fully invasive form, the molecular characteristics of the cell change as well. These characteristics can be considered a molecular
David B. Krizman +4 more
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Update of the Gene Discovery Program in Schistosoma mansoni with the Expressed Sequence Tag Approach
Memorias do Instituto Oswaldo Cruz, 1997 Continuing the Schistosoma mansoni Genome Project 363 new templates were sequenced generating 205 more ESTs corresponding to 91 genes. Seventy four of these genes (81%) had not previously been described in S. mansoni.
Élida ML Rabelo +8 more
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