Results 11 to 20 of about 11,389,397 (311)
Kennedy Institute of Ethics Journal, 1991 The Human Genome ...
Sharon J, Durfy, Amy E, Grotevant
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The Deep Genome Project. [PDF]
Genome Biol, 2020 In vivo research is critical to the functional dissection of multi-organ systems and whole organism physiology, and the laboratory mouse remains a quintessential animal model for studying mammalian, especially human, pathobiology. Enabled by technological innovations in genome sequencing, mutagenesis and genome editing, phenotype analyses, and ...
Lloyd KCK +43 more
europepmc +13 more sources
Genome Projects and the Functional-Genomic Era [PDF]
Combinatorial Chemistry & High Throughput Screening, 2005 The problems we face today in public health as a result of the -- fortunately -- increasing age of people and the requirements of developing countries create an urgent need for new and innovative approaches in medicine and in agronomics. Genomic and functional genomic approaches have a great potential to at least partially solve these problems in the ...
Sauer, S., Konthur, Z., Lehrach, H.
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Briefings in Functional Genomics and Proteomics, 2008 The medaka Oryzias latipes is a small egg-laying freshwater teleost, and has become an excellent model system for ecotoxicology, developmental genetics, genomics and evolutionary biology studies. A high-quality draft genome sequence (700 Mb) of the medaka inbred strain, Hd-rR, has now been completed. In this review, we present an overview of the medaka
Daisuke, Kobayashi, Hiroyuki, Takeda
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Deciphering Signatures of Mutational Processes Operative in Human Cancer
Cell Reports, 2013 The genome of a cancer cell carries somatic mutations that are the cumulative consequences of the DNA damage and repair processes operative during the cellular lineage between the fertilized egg and the cancer cell. Remarkably, these mutational processes
Ludmil B. Alexandrov +4 more
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Mutational signatures of ionizing radiation in second malignancies
Nature Communications, 2016 Ionizing radiation may induce irreparable DNA damage leading to cancer. Here, the authors identify a specific signature of mutations arising in patients exposed to ionizing radiation and suggest that radiation-induced tumorigenesis is associated with ...
Sam Behjati +32 more
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Virulence, 2021 Hungatella hathewayi has been observed to be a member of the gut microbiome. Unfortunately, little is known about this organism in spite of being associated with human fatalities; it is important to understand virulence mechanisms and epidemiological ...
Laura E. Hernández-Juárez +7 more
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Nature Communications, 2017 Osteosarcoma is a primary malignancy of bone that affects children and adults. Here, the authors sequence childhood and adult osteosarcomas, identifying mutations in insulin-like growth factor signalling genes and distinct genomic rearrangement profiles ...
Sam Behjati +32 more
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Direct Transcriptional Consequences of Somatic Mutation in Breast Cancer
Cell Reports, 2016 Disordered transcriptomes of cancer encompass direct effects of somatic mutation on transcription, coordinated secondary pathway alterations, and increased transcriptional noise.
Adam Shlien +36 more
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Systematic image‐driven analysis of the spatial Drosophila embryonic expression landscape
Molecular Systems Biology, 2010 Discovery of temporal and spatial patterns of gene expression is essential for understanding the regulatory networks and development in multicellular organisms.
Erwin Frise +2 more
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