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Advanced Science, EarlyView.DECENT is a deep learning method that enhances noninvasive preimplantation genetic testing by accurately reconstructing embryonic copy number variations (CNVs) from cell‐free DNA in spent embryo culture media. By mitigating maternal contamination, DECENT improves diagnostic accuracy, even with high contamination levels, offering a reliable, noninvasive
Zhenyi Zhang +3 more
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Advanced Science, EarlyView.In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang +10 more
wiley +1 more source
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Bioethics, 1991
The human genome project is a multinational project aimed at obtaining a detailed map and a complete DNA sequence of the human genome. It will have many scientific, medical, economic, ethical, legal, and social implications. A fundamental question to ask is "Whose genome project is it?" We can answer this question from different perspectives, and ...
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The human genome project is a multinational project aimed at obtaining a detailed map and a complete DNA sequence of the human genome. It will have many scientific, medical, economic, ethical, legal, and social implications. A fundamental question to ask is "Whose genome project is it?" We can answer this question from different perspectives, and ...
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The American Journal of Surgery, 1993
The Human Genome Project is an international effort to clone and sequence the entire human genome. This audacious undertaking, estimated to cost 200 million dollars per year and require 15 years to complete, promises to be one of the most revolutionary and captivating scientific endeavors ever conceived by mankind.
Michael Hurwitz +3 more
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The Human Genome Project is an international effort to clone and sequence the entire human genome. This audacious undertaking, estimated to cost 200 million dollars per year and require 15 years to complete, promises to be one of the most revolutionary and captivating scientific endeavors ever conceived by mankind.
Michael Hurwitz +3 more
openaire +2 more sources
Instrumentation for the Genome Project
Annual Review of Biomedical Engineering, 1999▪ Abstract Much of the recent rapid progress in large-scale genomic sequencing has been driven by the dramatic improvements both in the area of biological protocols and in the availability of improved laboratory instrumentation and automation platforms.
G. A. Miller +2 more
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Parasitology Today, 2000
So what have we learned? (1) We have almost obtained the information that should enable the identification of the vast majority of human genes; the importance and significance of this achievement cannot be overestimated. (2) Money talks loudly; sometimes, throwing lots of money at a problem really does solve it: irrespective of where the funding comes ...
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So what have we learned? (1) We have almost obtained the information that should enable the identification of the vast majority of human genes; the importance and significance of this achievement cannot be overestimated. (2) Money talks loudly; sometimes, throwing lots of money at a problem really does solve it: irrespective of where the funding comes ...
openaire +3 more sources
Australian Journal of Forensic Sciences, 2000
The human genome project will generate significant business opportunities through better targeted treatment of disease, says Grant Sutherland. Edited highlights of his recent address to CEDA SA follow.
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The human genome project will generate significant business opportunities through better targeted treatment of disease, says Grant Sutherland. Edited highlights of his recent address to CEDA SA follow.
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2020
Current high-throughput sequencing technologies allow us to acquire entire genomes in a very short time and at a relatively sustainable cost, thus resulting in an increasing diffusion of genetic test capabilities, in specialized clinical laboratories and research centers.
Gideon Giacomelli +12 more
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Current high-throughput sequencing technologies allow us to acquire entire genomes in a very short time and at a relatively sustainable cost, thus resulting in an increasing diffusion of genetic test capabilities, in specialized clinical laboratories and research centers.
Gideon Giacomelli +12 more
openaire +3 more sources