Results 21 to 30 of about 1,144,164 (329)

Towards the Physical Map of the Trypanosoma cruzi Nuclear Genome: Construction of YAC and BAC Libraries of the Reference Clone T. cruzi CL-Brener [PDF]

open access: yesMemorias do Instituto Oswaldo Cruz, 1997
Strategies to construct the physical map of the Trypanosoma cruzi nuclear genome have to capitalize on three main advantages of the parasite genome, namely (a) its small size, (b) the fact that all chromosomes can be defined, and many of them can be ...
I Ferrari   +31 more
doaj   +1 more source

Importance of HBsAg recognition by HLA molecules as revealed by responsiveness to different hepatitis B vaccines

open access: yesScientific Reports, 2021
Hepatitis B (HB) vaccines (Heptavax-II and Bimmugen) designed based on HBV genotypes A and C are mainly used for vaccination against HB in Japan. To determine whether there are differences in the genetic background associated with vaccine responsiveness,
Nao Nishida   +23 more
doaj   +1 more source

Medaka genome project [PDF]

open access: yesBriefings in Functional Genomics and Proteomics, 2008
The medaka Oryzias latipes is a small egg-laying freshwater teleost, and has become an excellent model system for ecotoxicology, developmental genetics, genomics and evolutionary biology studies. A high-quality draft genome sequence (700 Mb) of the medaka inbred strain, Hd-rR, has now been completed. In this review, we present an overview of the medaka
Daisuke, Kobayashi, Hiroyuki, Takeda
openaire   +2 more sources

Genome-wide copy number variation analysis of hepatitis B infection in a Japanese population

open access: yesHuman Genome Variation, 2021
Hepatitis B: Gene copy numbers associated with risk of infection The risk of contracting the hepatitis B virus may be linked to the number of copies of certain genes in an individual’s genome.
Masataka Kikuchi   +7 more
doaj   +1 more source

Claspin-Dependent and -Independent Chk1 Activation by a Panel of Biological Stresses

open access: yesBiomolecules, 2023
Replication stress has been suggested to be an ultimate trigger of carcinogenesis. Oncogenic signal, such as overexpression of CyclinE, has been shown to induce replication stress. Here, we show that various biological stresses, including heat, oxidative
Hao-Wen Hsiao   +2 more
doaj   +1 more source

The Feline Genome Project [PDF]

open access: yesAnnual Review of Genetics, 2002
▪ Abstract  The compilation of a dense gene map and eventually a whole genome sequence (WGS) of the domestic cat holds considerable value for human genome annotation, for veterinary medicine, and for insight into the evolution of genome organization among mammals.
O'Brien, Stephen J.   +3 more
openaire   +2 more sources

Analysis of SARS-CoV-2 genomic epidemiology reveals disease transmission coupled to variant emergence and allelic variation

open access: yesScientific Reports, 2021
The spread of SARS-CoV-2 created a pandemic crisis with > 150,000 cumulative cases in > 65 countries within a few months. The reproductive number (R) is a metric to estimate the transmission of a pathogen during an outbreak.
D J Darwin R. Bandoy, Bart C. Weimer
doaj   +1 more source

Molecular tools to monitor health and disease – and lucky coincidences

open access: yesUpsala Journal of Medical Sciences, 2022
Improved methods for molecular analyses are obviously central for medical research. I will describe herein our work developing tools to reveal molecular states in health and disease.
Ulf Landegren
doaj   +1 more source

Deciphering Signatures of Mutational Processes Operative in Human Cancer

open access: yesCell Reports, 2013
The genome of a cancer cell carries somatic mutations that are the cumulative consequences of the DNA damage and repair processes operative during the cellular lineage between the fertilized egg and the cancer cell. Remarkably, these mutational processes
Ludmil B. Alexandrov   +4 more
doaj   +1 more source

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