Results 21 to 30 of about 1,073,692 (309)

Deciphering Signatures of Mutational Processes Operative in Human Cancer

Cell Reports, 2013
The genome of a cancer cell carries somatic mutations that are the cumulative consequences of the DNA damage and repair processes operative during the cellular lineage between the fertilized egg and the cancer cell. Remarkably, these mutational processes
Ludmil B. Alexandrov, Serena Nik-Zainal, David C. Wedge, Peter J. Campbell, Michael R. Stratton   +4 more
doaj   +1 more source

Salmonella enhances osteogenic differentiation in adipose-derived mesenchymal stem cells

Frontiers in Cell and Developmental Biology, 2023
The potential of mesenchymal stem cells (MSCs) for tissue repair and regeneration has garnered great attention. While MSCs are likely to interact with microbes at sites of tissue damage and inflammation, like in the gastrointestinal system, the ...
Nuradilla Mohamad-Fauzi, Claire Shaw, Soraya H. Foutouhi, Matthias Hess, Nguyet Kong, Amir Kol, Dylan Bobby Storey, Prerak T. Desai, Jigna Shah, Dori Borjesson, James D. Murray, James D. Murray, Bart C. Weimer   +12 more
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Mutational signatures of ionizing radiation in second malignancies

Nature Communications, 2016
Ionizing radiation may induce irreparable DNA damage leading to cancer. Here, the authors identify a specific signature of mutations arising in patients exposed to ionizing radiation and suggest that radiation-induced tumorigenesis is associated with ...
Sam Behjati, Gunes Gundem, David C. Wedge, Nicola D. Roberts, Patrick S. Tarpey, Susanna L. Cooke, Peter Van Loo, Ludmil B. Alexandrov, Manasa Ramakrishna, Helen Davies, Serena Nik-Zainal, Claire Hardy, Calli Latimer, Keiran M. Raine, Lucy Stebbings, Andy Menzies, David Jones, Rebecca Shepherd, Adam P. Butler, Jon W. Teague, Mette Jorgensen, Bhavisha Khatri, Nischalan Pillay, Adam Shlien, P. Andrew Futreal, Christophe Badie, ICGC Prostate Group, Ultan McDermott, G. Steven Bova, Andrea L. Richardson, Adrienne M. Flanagan, Michael R. Stratton, Peter J. Campbell   +32 more
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Molecular tools to monitor health and disease – and lucky coincidences

Upsala Journal of Medical Sciences, 2022
Improved methods for molecular analyses are obviously central for medical research. I will describe herein our work developing tools to reveal molecular states in health and disease.
Ulf Landegren
doaj   +1 more source

Genome Network Project: An Integrated Genomic Platform [PDF]

, 2009
With the objective of elucidating the structure of gene interactions in the human genome, the Genome Network Project has generated a vast quantity of experimental data, mainly focusing on transcriptional control and transcription-factor related protein ...
Jose C. Clemente, Kazuho Ikeo, So Nakagawa, Takashi Gojobori   +3 more
core   +2 more sources

Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma

Nature Communications, 2017
Osteosarcoma is a primary malignancy of bone that affects children and adults. Here, the authors sequence childhood and adult osteosarcomas, identifying mutations in insulin-like growth factor signalling genes and distinct genomic rearrangement profiles ...
Sam Behjati, Patrick S. Tarpey, Kerstin Haase, Hongtao Ye, Matthew D. Young, Ludmil B. Alexandrov, Sarah J. Farndon, Grace Collord, David C. Wedge, Inigo Martincorena, Susanna L. Cooke, Helen Davies, William Mifsud, Mathias Lidgren, Sancha Martin, Calli Latimer, Mark Maddison, Adam P. Butler, Jon W. Teague, Nischalan Pillay, Adam Shlien, Ultan McDermott, P. Andrew Futreal, Daniel Baumhoer, Olga Zaikova, Bodil Bjerkehagen, Ola Myklebost, M. Fernanda Amary, Roberto Tirabosco, Peter Van Loo, Michael R. Stratton, Adrienne M. Flanagan, Peter J. Campbell   +32 more
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Direct Transcriptional Consequences of Somatic Mutation in Breast Cancer

Cell Reports, 2016
Disordered transcriptomes of cancer encompass direct effects of somatic mutation on transcription, coordinated secondary pathway alterations, and increased transcriptional noise.
Adam Shlien, Keiran Raine, Fabio Fuligni, Roland Arnold, Serena Nik-Zainal, Serge Dronov, Lira Mamanova, Andrej Rosic, Young Seok Ju, Susanna L. Cooke, Manasa Ramakrishna, Elli Papaemmanuil, Helen R. Davies, Patrick S. Tarpey, Peter Van Loo, David C. Wedge, David R. Jones, Sancha Martin, John Marshall, Elizabeth Anderson, Claire Hardy, Violetta Barbashina, Samuel A.J.R. Aparicio, Torill Sauer, Øystein Garred, Anne Vincent-Salomon, Odette Mariani, Sandrine Boyault, Aquila Fatima, Anita Langerød, Åke Borg, Gilles Thomas, Andrea L. Richardson, Anne-Lise Børresen-Dale, Kornelia Polyak, Michael R. Stratton, Peter J. Campbell   +36 more
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The Human Genome Project [PDF]

Journal of the Royal Society of Medicine, 2005
On 14 April 2003 the US Human Genome Research Institute announced that scientists had just clipped into place the very last piece in the colossal jigsaw of human DNA. The next day's newspapers reminded us that, whilst it was early days yet, a host of diseases from eczema to dementia could one day be history.
openaire   +3 more sources

Systematic image‐driven analysis of the spatial Drosophila embryonic expression landscape

Molecular Systems Biology, 2010
Discovery of temporal and spatial patterns of gene expression is essential for understanding the regulatory networks and development in multicellular organisms.
Erwin Frise, Ann S Hammonds, Susan E Celniker   +2 more
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Genetic association of IL17 and the importance of ABO blood group antigens in saliva to COVID-19

Scientific Reports, 2022
The outbreak of COVID-19 caused by infection with SARS-CoV-2 virus has become a worldwide pandemic, and the number of patients presenting with respiratory failure is rapidly increasing in Japan.
Nao Nishida, Masaya Sugiyama, Yosuke Kawai, Izumi Naka, Noriko Iwamoto, Tetsuya Suzuki, Michiyo Suzuki, Yusuke Miyazato, Satoshi Suzuki, Shinyu Izumi, Masayuki Hojo, Takayo Tsuchiura, Miyuki Ishikawa, Jun Ohashi, Norio Ohmagari, Katsushi Tokunaga, Masashi Mizokami   +16 more
doaj   +1 more source