Results 91 to 100 of about 1,118,249 (314)

Distribution of Polymorphic and Non-Polymorphic Microsatellite Repeats in

Bioinformatics and Biology Insights, 2008
The results of our bioinformatics analysis have found over 91,000 di-, tri-, and tetranucleotide microsatellites in our survey of 25% of the X. tropicalis genome, suggesting there may be over 360,000 within the entire genome. Within the X.
Zhenkang Xu, Laura Gutierrez, Matthew Hitchens, Steve Scherer, Amy K. Sater, Dan E. Wells   +5 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Bioinformatics' approaches to detect genetic variation in whole genome sequencing data

, 2010
Current genetic marker repositories are not sufficient or even are completely lacking for most farm animals. However, genetic markers are essential for the development of a research tool facilitating discovery of genetic factors that contribute to ...
Kerstens, H.H.D.
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Illuminating Choices for Library Prep: A Comparison of Library Preparation Methods for Whole Genome Sequencing of Cryptococcus neoformans Using Illumina HiSeq. [PDF]

, 2014
The industry of next-generation sequencing is constantly evolving, with novel library preparation methods and new sequencing machines being released by the major sequencing technology companies annually.
Mathew A Beale, Fisher, Matthew C, Rhodes Johanna, Matthew C Fisher, Rhodes, Johanna, Beale Mathew A., Fisher, MC, Beale, Mathew A, Fisher, Matthew C., Beale, Mathew A., Fisher Matthew C., Beale, MA, Rhodes, J, Johanna Rhodes, Rhodes, Johanna; id_orcid   +14 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Analysis of the giant genomes of Fritillaria (Liliaceae) indicates that a lack of DNA removal characterizes extreme expansions in genome size. [PDF]

, 2015
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.Plants exhibit an extraordinary range of genome sizes,
Novák, P, Pellicer, J., Fay, M. F., Leitch, IJ, Neumann, P., Peter D. Day, Leitch, A. R., Pellicer, J, Michael F. Fay, Petr Novák, Ilia J. Leitch, Day, PD, Kelly, L. J., Richard A. Nichols, Pavel Neumann, Lysak, M. A., Laura J. Kelly, Neumann, P, Jaume Pellicer, Nichols, RA, Andrew R. Leitch, Macas, J., Macas, J, Novak, P., Leitch, I. J., Lysak, M., Berger, M., Lysak, MA, Day, P. D., Martin A. Lysak, Renny-Byfield, S, Leitch, AR, Nichols, R. A., Jiří Macas, Simon Renny‐Byfield, Kelly, LJ, Berger, M, Fay, MF, Madeleine Berger, Renny-Byfield, S.   +39 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Burkholderia pseudomallei sequencing identifies genomic clades with distinct recombination, accessory, and epigenetic profiles.

, 2014
Burkholderia pseudomallei (Bp) is the causative agent of the infectious disease melioidosis. To investigate population diversity, recombination, and horizontal gene transfer in closely related Bp isolates, we performed whole-genome sequencing (WGS) on ...
Studholme, David J., Holden, Mathew TG, Ong, C, Beacham, I, Parkhill, J, Harting, J, Chen, Swaine L., Mehershahi, K, Holden, Matthew T. G., Nandi, T, T.G. Holden, Matthew, Didelot, X, Peak, I, Baybayan, Primo, Peak, Ian, Sim, B, Hoon, CH, Nandi, Tannistha, Boddey, J, Boddey, Justin, Boddey, Justin A., Holden, Matthew, J. Studholme, David, Baybayan, P, Michell, S, Essex-Lopresti, AE, Guo, Yan, Sim, Bernice, Didelot, Xavier, Titball, Richard W., Chen, SL, Smither, Sophie, Smiters, Sophie, Beacham, Ifor, Holden, Matthew TG, Smither, S, How, LC, Nelson, Michelle, Ong, Catherine, Tan, P, Wang, S, Aw, LT, Nelson, M, Mitchell, Stephen, Michell, Stephen, Aw, Lay Tin, E. Essex-Lopresti, Angela, Chen, Swaine, Chen, Swaine L, Titball, Richard, Mehrashahi, Kurosh, Hoon, Chua Hui, Boddey, Justin A, Sarkar-Tyson, M, Parkhill, Julian, Mehershahi, Kurosh, Guo, Y, Tan, Patrick, How, Lee Chee, W. Titball, Richard, Sarkar-Tyson, Mitali, Wang, Susana, Essex-Lopresti, Angela, Studholme, David J, Harting, John   +64 more
core   +1 more source

Uninformative polymorphisms bias genome scans for signatures of selection [PDF]

, 2012
With the establishment of high-throughput sequencing technologies and new methods for rapid and extensive single nucleotide (SNP) discovery, marker-based genome scans in search of signatures of divergent selection between populations occupying ...
Daniel Berner, Roesti Marius, Berner Daniel, Marius Roesti, Salzburger Walter, Walter Salzburger, Salzburger, Walter, Berner, Daniel, Roesti, Marius   +8 more
core   +1 more source