Results 141 to 150 of about 1,118,249 (314)

Genomic exploration of pediatric neurological disorders: a case series

Journal of Medical Case Reports
Background Pediatric neurological disorders include neurodegenerative diseases causing cognitive impairment and vision loss. They are one of the important causes of morbidity and mortality in children with diverse etiologies.
Naresh Tayade, Gautham Manoj, Akshay Kewat, Anjali Krishna A, Rajiv Devulapalli, Somesh Kumar, Sunil Kumar Polipalli, Bipin G. Nair, Obul Reddy Bandapalli, Prashanth Suravajhala   +9 more
doaj   +1 more source

Nanopore adaptive sampling effectively enriches bacterial plasmids

mSystems
Bacterial plasmids play a major role in the spread of antibiotic resistance genes. However, their characterization via DNA sequencing suffers from the low abundance of plasmid DNA in those samples.
Jens-Uwe Ulrich, Lennard Epping, Tanja Pilz, Birgit Walther, Kerstin Stingl, Torsten Semmler, Bernhard Y. Renard   +6 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

W088: Impacts of the Durum Wheat Genome Outputs for Breeding

, 2017
Triticum turgidum tetraploid wheat species, with wild emmer ssp. dicoccoides, domesticated emmer ssp. dicoccum and durum wheat (ssp. durum) is a cornerstone of the wheat polyploidy complex.
L. Cattivelli, M. Maccaferri, The International Durum Wheat Genome Sequencing Consortium   +2 more
core  

Geoseq: a tool for dissecting deep-sequencing datasets

, 2010
Gurtowski J, Cancio A, Shah H, et al. Geoseq: a tool for dissecting deep-sequencing datasets. BMC Bioinformatics. 2010;11(1): 506.Background Datasets generated on deep-sequencing platforms have been deposited in various public repositories such as the ...
Gurtowski, James, Sachidanandam, Ravi, Robert Homann, Shah Hardik, Chaya Levovitz, Ravi Sachidanandam, Hardik Shah, James Gurtowski, Cancio, Anthony, Levovitz Chaya, George Ajish, Cancio Anthony, Homann, Robert, Anthony Cancio, Shah, Hardik, Homann Robert, Levovitz, Chaya, Sachidanandam Ravi, Ajish George, George, Ajish, Gurtowski James   +20 more
core   +1 more source

Germline structural variations involving the pediatric brain tumor transcriptome include disease-relevant and ancestry-related genes

Acta Neuropathologica Communications
Background Germline Structural Variants (SVs) represent an important source of genetic diversity, in large part due to their influence on gene transcription.
Fengju Chen, Yiqun Zhang, Luis F. Paulin, Fritz J. Sedlazeck, Chad J. Creighton   +4 more
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source