Results 61 to 70 of about 2,337,583 (311)

Leveraging the Assembly of the Durum Wheat Genome cv. Svevo

, 2017
Tetraploid wheat species, with his two wild and cultivated subspecies T. turgidum ssp. dicoccoides and ssp. durum, is a cornerstone of the wheat polyploidy complex.
The International Durum Wheat Sequencing Consortium, The International Durum wheat Genome Sequencing Consortium, L. Cattivelli, M. Maccaferri   +3 more
core   +1 more source

Tracking updates in clinical databases increases efficiency for variant reanalysis

Genetics in Medicine Open
Purpose: Variant interpretation, guided by American College of Medical Genetics and Genomics guidelines, can inform clinical decision-making. However, interpretations may change over time for a variety of reasons.
Lele Li, Xia Tian, Vaughan Woodzell, Richard A. Gibbs, Bo Yuan, Eric Venner   +5 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

K-mer analysis of long-read alignment pileups for structural variant genotyping

Nature Communications
Accurately genotyping structural variant (SV) alleles is crucial to genomics research. We present a novel method (kanpig) for genotyping SVs that leverages variant graphs and k-mer vectors to rapidly generate accurate SV genotypes.
Adam C. English, Fabio Cunial, Ginger A. Metcalf, Richard A. Gibbs, Fritz J. Sedlazeck   +4 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Genome Evolution and Innovation across the Four Major Lineages of Cryptococcus gattii

mBio, 2015
Cryptococcus gattii is a fungal pathogen of humans, causing pulmonary infections in otherwise healthy hosts. To characterize genomic variation among the four major lineages of C.
Rhys A. Farrer, Christopher A. Desjardins, Sharadha Sakthikumar, Sharvari Gujja, Sakina Saif, Qiandong Zeng, Yuan Chen, Kerstin Voelz, Joseph Heitman, Robin C. May, Matthew C. Fisher, Christina A. Cuomo   +11 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Whole genome sequencing reveals local transmission patterns of mycobacterium bovis in sympatric cattle and badger populations [PDF]

, 2012
Whole genome sequencing (WGS) technology holds great promise as a tool for the forensic epidemiology of bacterial pathogens. It is likely to be particularly useful for studying the transmission dynamics of an observed epidemic involving a largely ...
O'Hare, Anthony, Stanley McDowell, Mallon Tom, Orton, Richard, Mallon, Tom, Biek, R., O'Hare, A., Robin A. Skuce (116935), Kao, R.R., Skuce, Robin A, Tom Mallon, David Wright, Orton Richard J., Kao, Rowland R., Rowland R Kao, McCormick, Carl, Wright David, Biek Roman, Hannah Trewby (116929), Richard J. Orton (116918), Skuce Robin A., Hannah Trewby, McDowell, S., Kao Rowland R., Kao, Rowland R, Trewby, Hannah, Carl McCormick, Skuce, Robin A., Tom Mallon (116914), McCormick, C., David Wright (116911), Mallon, T., Roman Biek (21981), Roman Biek, Wright, D., McCormick Carl, Richard J Orton, McDowell, Stanley, Trewby Hannah, Orton, Richard J., Anthony O'Hare (116908), O'Hare Anthony, McDowell Stanley, Trewby, H., Robin A Skuce, Wright, David; id_orcid, Biek, Roman, Carl McCormick (116915), Stanley McDowell (116923), Wright, David, Orton, R.J., Rowland R. Kao (116940), Skuce, R.A., Anthony O'Hare   +53 more
core   +1 more source

The genomic landscape of molecular responses to natural drought stress in Panicum hallii

Nature Communications, 2018
Drought is a major factor limiting crop productivity. Here, via eQTL analysis and comparative genomics, the authors show compensatory evolution between trans-regulatory loci and transcription factor binding sites that shape the drought response networks ...
John T. Lovell, Jerry Jenkins, David B. Lowry, Sujan Mamidi, Avinash Sreedasyam, Xiaoyu Weng, Kerrie Barry, Jason Bonnette, Brandon Campitelli, Chris Daum, Sean P. Gordon, Billie A. Gould, Albina Khasanova, Anna Lipzen, Alice MacQueen, Juan Diego Palacio-Mejía, Christopher Plott, Eugene V. Shakirov, Shengqiang Shu, Yuko Yoshinaga, Matt Zane, Dave Kudrna, Jason D. Talag, Daniel Rokhsar, Jane Grimwood, Jeremy Schmutz, Thomas E. Juenger   +26 more
doaj   +1 more source

Primary Infection May Be an Underlying Factor Contributing to Lethal Hemorrhagic Disease Caused by Elephant Endotheliotropic Herpesvirus 3 in African Elephants (Loxodonta africana)

Microbiology Spectrum, 2021
Distinct but related species of elephant endotheliotropic herpesviruses (EEHVs) circulate within Asian and African elephant populations. Primary infection with EEHVs endemic among Asian elephants can cause clinical illness and lethal EEHV hemorrhagic ...
Taylor Pursell, Jennifer L. Spencer Clinton, Jie Tan, Rongsheng Peng, Xiang Qin, Harshavardhan Doddapaneni, Vipin Menon, Zeineen Momin, Kavya Kottapalli, Lauren Howard, Erin Latimer, Sarah Heaggans, Gary S. Hayward, Paul D. Ling   +13 more
doaj   +1 more source