Results 101 to 110 of about 5,760,584 (260)
Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun +9 morewiley +1 more sourceAncient Polyploidy and Genome Evolution in Palms [PDF]
, 2019 Mechanisms of genome evolution are fundamental to our understanding of adaptation and the generation and maintenance of biodiversity, yet genome dynamics are still poorly characterized in many clades.Bacon, Christine D.,, Sinn, Brandon T., Ge, Xue Jun, Bacon, Christine D., Barrett, Craig F, Barrett, Craig F., McKain, Michael, Bacon, Christine, Barrett, Craig, Ge, Xue-Jun, Antonelli, Alexandre, Zhang, Yuqu, Ge, X. J., Zhang, Y. Q., McKain, M. R., Antonelli, Alexandre,, Sinn, B. T., McKain, Michael R., Sinn, Brandon, Barrett, C. F. +19 morecore +1 more sourcePharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller +16 morewiley +1 more sourceUnraveling the genomic mosaic of a ubiquitous genus of marine cyanobacteria [PDF]
, 2008 Background: The picocyanobacterial genus Synechococcus occurs over wide oceanic expanses, having colonized most
available niches in the photic zone. Large scale distribution patterns of the different Synechococcus clades (based on 16S rRNA gene markers) Ostrowski, Martin, Frederic Partensky, Ferriera, S, Brian P Palenik, Wincker, Patrick, Scanlan, David J., David J Scanlan, Patrick Wincker, Johnson, Justin, Ferriera, Steve, de Marsac, NT, Johnson, J, Paulsen, Ian, T., Paulsen, Ian T, Garczarek, L, Laurence Garczarek, Post, AF, Tandeau de Marsac, Nicole, Steve Ferriera, Wincker, P, Dufresne, A, Post, Anton F., Partensky, Frédéric, Martin Ostrowski, Carole Dossat, Hess, Wolfgang R., Paulsen, Ian T., Nicole Tandeau de Marsac, Dossat, Carole, Scanlan, DJ, Sophie Mazard, Dossat, C, Dufresne, Alexis, Mazard, Sophie, Ostrowski, M, Palenik, BP, Hess, WR, Garczarek, Laurence, Justin Johnson, Mazard, S, Paulsen, IT, Ian T Paulsen, de Marsac, Nicole Tandeau, Anton F Post, Scanlan, David, J., Palenik, Brian P., Partensky, F, Wolfgang R Hess, Alexis Dufresne, Hess, Wolfgang, Palenik, Brian P +50 morecore +1 more sourceIntrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen +10 morewiley +1 more sourceFinished Genome of the Fungal Wheat Pathogen Mycosphaerella graminicola Reveals Dispensome Structure, Chromosome Plasticity, and Stealth Pathogenesis [PDF]
, 2011 The plant-pathogenic fungus Mycosphaerella graminicola (asexual stage: Septoria tritici) causes septoria tritici blotch, a disease that greatly reduces the yield and quality of wheat.van de Geest, HC, Rahim Mehrabi, de Vries, Ronald P., Dehal Paramvir, Donzelli Bruno, Conde-Ferràez, Laura, Stefano F F Torriani, Kema Gert H. J., Roeland C H J van Ham, Goodwin, S. B., Lombard, V., Nap Jan P. H., Ware, SB, Henrissat, B., Cools Hans J., Waalwijk, C, Oliver, R.P., Wiebenga, A., Wittenberg, Alexander HJ, Hane, James K., Kourmpetis Yiannis, De Wit, P., Maliepaard, C., Schouten, H., Jason J. Rudd, Goodwin, SB, Donzelli, B., Sarah B Ware, Ware Sarah B., Grigoriev, I.V., Kema, GHJ, Henk J Schouten, Van der Lee, Theo AJ, Stephen B. Goodwin, Schouten, HJ, Wittenberg, A. H. J., Foster, Andrew J, Theo A. J. Van der Lee, Jan P H Nap, Churchill, A.C.L., Lindquist, Erika, Kourmpetis, Y., de Wit, P.J.G.M., Hane James K., Donzelli, B, Aerts, Andrea, Churchill, Alice CL, M’Barek, Sarrah Ben, Charles F Crane, Ponomarenko, A., Ioannis Stergiopoulos, Andrew J. Foster, Hane, J.K., Foster, A.J., Laura Conde-Ferràez, Adilson K Kobayashi, Van Der Lee, T. A. J., Bruno Donzelli, Kilian Andrzej, Wiebenga, A, Kilian, A, Bowler, J., Bristow, J., Igor V Grigoriev, Pedro M Coutinho, Wittenberg, AHJ, Zwiers, L.H., Roeland C. H. J. van Ham, Foster, Andrew J., Cools, H.J., Ware, Sarah B, Chris Maliepaard, Foster Andrew J., Dehal, P, Dehal, Paramvir, Stefano F. F. Torriani, Ware, Sara B, Jane Grimwood, van der Burgt Ate, Kourmpetis, Yiannis, Goodwin, Stephen B., Rudd Jason J., Csukai Michael, Van der Lee, TAJ, Kim E Hammond-Kosack, Bailey Andy, Cees Waalwijk, Ware, Sarah B., Andy Bailey, Canto-Canché Blondy, Kobayashi, Adilson K., van de Geest, Henri C., Conde-Ferràez, L, Lindquist, E, Nap, Jan P.H., Burt Bluhm, Kilan, Andrzej, Maliepaard, Chris, Lindquist Erika, Hans J. Cools, Aerts, A, Edda Koopmann, Stephen B Goodwin, Bowler, Judith, Tu, H., Canto-Canché, B, van der Burgt, A., M\u27Barek, Sarrah Ben, Maliepaard, C, Hammond-Kosack Kim E., Koopmann, E, Martins, Natalia, Koopmann Edda, Paramvir Dehal, Wittenberg, Alexander H. J., Waalwijk, Cees, Bowler Judith, Hammond-Kosack, K.E., Foster, AJ, Dehal, P., Gert H J Kema, Dhillon Braham, Harris Shapiro, Wiebenga, Ad, Cools, Hans J., Geest, H.C., van de, Vries, R.P., de, Kim E. Hammond-Kosack, Lombard Vincent, Torriani Stefano F. F., Grigoriev Igor V., Koopmann, Edda, Lombard, V, Kobayashi, AK, van der Burgt, A, James K Hane, Coutinho, P.M., Ponomarenko, A, Crane, Charles F., M'Barek, S., Ben, Crane, C.F., Antoniw, J, Bristow, J, Schouten, Henk J., Antoniw, John, Gert H. J. Kema, Van der Lee, Theo A. J., Martins, N., Torriani, S.F.F., Ate van der Burgt, Hank Tu, Cools, Hans J, Rudd, J. J., Churchill, ACL, Goodwin, S.B., Csukai, Michael, Coutinho, P. M., Foster, A. J., Charles F. Crane, Grigoriev, IV, Pierre De Wit, Asaf Salamov, Grimwood, J, Henk J. Schouten, Crane, C. F., Antoniw, J. F., De Wit Pierre, Stergiopoulos, I., Henri C. van de Geest, Salamov, A., Salamov Asaf, Kobayashi, A.K., Oliver, RP, Coutinho, Pedro M., Schouten, H.J., Ware, S.B., Pedro M. Coutinho, Bailey, A., Goodwin Stephen B., Grimwood Jane, Schouten Henk J., van Ham, Roeland C.H.J., Mehrabi, R, Churchill, Alice C.L., Arnold Kuzniar, Oliver, Richard P, Lee, T.A.J., van der, van Ham, Roeland CHJ, Henrissat, Bernard, Kema, G.H.J., James K. Hane, de Wit, P, Alice C L Churchill, Van der Lee, Theo A.J., Yiannis Kourmpetis, Maliepaard, C.A., Churchill, Alice C. L., Oliver, Richard P., Schmutz, Jeremy, Kobayashi Adilson K., Richard P Oliver, Alice C. L. Churchill, Kema, Gert H.J., Conde-Ferràez, L., de Vries Ronald P., Van der Lee, T.A.J., Crane Charles F., M'Barek, SB, Grimwood, Jane, Kilian, Andrzej, Antoniw, J., Maliepaard Chris, Hammond-Kosack, K. E., Martins, N, Grigoriev, Igor V, Rudd, J.J., Coutinho Pedro M., Jim Bristow, Wittenberg Alexander H. J., Nap, J.P.H., John Antoniw, van der Burgt, Ate, Henrissat, B, Torriani, SFF, Wiebenga Ad, Lombard, Vincent, Rudd, Jason J, Ad Wiebenga, van de Geest, Henri C, Andrea Aerts, Martins Natalia, Koopmann, E., Bernard Henrissat, Kuzniar Arnold, Bluhm, Burt, Shapiro, H., Donzelli, Bruno, Hans J Cools, Antoniw John, Wittenberg, Alexander H.J., Churchill, A. C. L., Bristow, Jim, Vincent Lombard, van de Geest Henri C., Shapiro, Harris, Van De Geest, H. C., Alexander H. J. Wittenberg, Hane, James K, Bowler, J.M., Henri C van de Geest, Bluhm, B., Mehrabi Rahim, Waalwijk Cees, Adilson K. Kobayashi, Nap, Jan P. H., Ham, R.C.H.J., van, Ben M'Barek Sarrah, Mehrabi, Rahim, Jeremy Schmutz, Aerts Andrea, Schouten, Henk J, Bristow Jim, Canto-Canché, B., Blondy Canto-Canché, Hammond-Kosack, Kim E, Braham Dhillon, van de Geest, H.C., Stergiopoulos Ioannis, Schmutz, J, Jason J Rudd, Bluhm, B, Hane, J. K., Van Ham, R. C. H. J., Nap, JPH, Crane, CF, Stergiopoulos, I, Alexander H J Wittenberg, Salamov, Asaf, Nap, Jan PH, van Ham, Roel C. H. J., Shapiro Harris, Schmutz, J., Michael Csukai, de Vries, RP, van Ham Roeland C. H. J., Zwiers, Lute-Harm, Torriani, Stefano F.F., Judith Bowler, Dhillon, B., Burgt, A., van der, Sarrah Ben M'barek, Salamov, A, Crane, Charles F, Kobayashi, Adilson K, Richard P. Oliver, Goodwin, Stephen B, Ponomarenko Alisa, Bowler, J, Bailey, Andy, Natalia Martins, van Ham, RCHJ, Tu Hank, Coutinho, PM, Kourmpetis, Y, Bluhm Burt, Zwiers, L-H, Hane, JK, Csukai, M, de Vries, Ronald P, M'Barek, Sarrah B., Oliver Richard P., Geest, H.G., Van der Lee Theo A. J., Cools, HJ, Alisa Ponomarenko, Aerts, A., Andrzej Kilian, Zwiers Lute-Harm, Grigoriev, Igor V., Csukai, M., Henrissat Bernard, Dhillon, Braham, Kilian, A., Wittenberg, A.H.J., Kema, Gert. H. J., Rudd, JJ, Ben M'Barek, S., Wit, P.J.G.M., de, Tu, H, Conde-Ferràez Laura, Lindquist, E., Waalwijk, C., Lute-Harm Zwiers, Erika Lindquist, Mehrabi, A., Kuzniar, A, Dhillon, B, De Wit, Pierre, Canto-Canché, Blondy, Rudd, Jason J., Ponomarenko, Alisa, Coutinho, Pedro M, Ronald P de Vries, van Ham, R.C.H.J., Andrew J Foster, Shapiro, H, Hammond-Kosack, KE, Mehrabi, R., Torriani, Stefano FF, Schmutz Jeremy, Kuzniar, A., Kema, Gert HJ, M'barek, Sarrah Ben, Bailey, AM, Hammond-Kosack, Kim E., Grimwood, J., Jan P. H. Nap, de Vries, R.P., Stergiopoulos, Ioannis, Theo A J Van der Lee, Ronald P. de Vries, Sarah B. Ware, Igor V. Grigoriev, Churchill Alice C. L., Kuzniar, Arnold, Tu, Hank, van Ham, R.C.H., Cools, H. J. +367 morecore +2 more sourcesSomatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan +6 morewiley +1 more sourceProfiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic +10 morewiley +1 more source
