Results 321 to 330 of about 1,403,931 (355)
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Advances in structural genomics
Current Opinion in Structural Biology, 1999New computational techniques have allowed protein folds to be assigned to all or parts of between a quarter (Caenorhabditis elegans) and a half (Mycoplasma genitalium) of the individual protein sequences in different genomes. These assignments give a new perspective on domain structures, gene duplications, protein families and protein folds in genome ...
Cyrus Chothia +2 more
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Genome structure of spirochetes
Research in Microbiology, 1992The genome structures of several pathogenic spirochetes have recently been determined. The genomes of Borrelia species consist of a linear chromosome of approximately one million base pairs (Mb) and various linear and circular plasmids. Analysis of restriction fragment length polymorphisms and 16S ribosomal RNA sequence data indicate the division of ...
I. Saint Girons +5 more
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Structural genomics in endocrinology
Pharmacogenomics, 2001Traditionally, endocrine research evolved from the phenotypical characterisation of endocrine disorders to the identification of underlying molecular pathophysiology. This approach has been, and still is, extremely successful. The introduction of genomics and proteomics has resulted in a reversal of this sequence of endocrine research: reverse ...
Jan W. A. Smit, Johannes A. Romijn
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Science, 2018
Genome Structure Beyond the sequence of the genome, its three-dimensional structure is important in regulating gene expression. To understand cell-to-cell variation, the structure needs to be understood at a single-cell level. Chromatin conformation capture methods have allowed characterization of genome structure in haploid cells.
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Genome Structure Beyond the sequence of the genome, its three-dimensional structure is important in regulating gene expression. To understand cell-to-cell variation, the structure needs to be understood at a single-cell level. Chromatin conformation capture methods have allowed characterization of genome structure in haploid cells.
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Genome Structure and Comparative Genomics
2016Two genome assemblies have been generated for Setaria italica, one in the accession Yugu1 and one in the accession Zhang gu. A comparison of the two assemblies showed overall high levels of colinearity, but identified a number of likely misoriented and/or misplaced sequence scaffolds.
Xiaomei Wu, Peng Qi, Katrien M. Devos
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Trends in Biotechnology, 2005
G protein-coupled receptors (GPCRs) are targets for 60-70% of drugs in development today. Traditionally, the drug discovery process has relied on screening of chemical compounds to identify novel and more-efficient drug molecules. Structure-based drug design, however, provides a targeted approach but has been severely hampered by limited knowledge of ...
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G protein-coupled receptors (GPCRs) are targets for 60-70% of drugs in development today. Traditionally, the drug discovery process has relied on screening of chemical compounds to identify novel and more-efficient drug molecules. Structure-based drug design, however, provides a targeted approach but has been severely hampered by limited knowledge of ...
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Nature Reviews Genetics, 2001
Structural genomics projects aim to provide an experimental or computational three-dimensional model structure for all of the tractable macromolecules that are encoded by complete genomes. To this end, pilot centres worldwide are now exploring the feasibility of large-scale structure determination. Their experimental structures and computational models
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Structural genomics projects aim to provide an experimental or computational three-dimensional model structure for all of the tractable macromolecules that are encoded by complete genomes. To this end, pilot centres worldwide are now exploring the feasibility of large-scale structure determination. Their experimental structures and computational models
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Mycobacterial genome structure (minireview)
ELECTROPHORESIS, 1998AbstractGenome maps have been constructed for the mycobacterial pathogens Mycobacterium leprae and Mycobacterium tuberculosis, as well as for the attenuated vaccine strain Mycobacterium bovis BCG Pasteur. While the chromosomes of M. tuberculosis and M. bovis BCG Pasteur show extensive conservation at the grosslevel, comparison with M. leprae revealed a
Amalio Telenti +3 more
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1985
Publisher Summary This chapter describes the human genome structure. The diploid human genome is organized into 23 pairs of chromosomes of which 22 pairs are autosomes and one pair is the sex chromosomes. Molecular analysis of the structure and organization of the eukaryotic genome revealed the presence of large amounts of repetitive DNA sequences ...
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Publisher Summary This chapter describes the human genome structure. The diploid human genome is organized into 23 pairs of chromosomes of which 22 pairs are autosomes and one pair is the sex chromosomes. Molecular analysis of the structure and organization of the eukaryotic genome revealed the presence of large amounts of repetitive DNA sequences ...
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1984
Adenovirus particles have a highly ordered structure and are composed of protein and DNA. Human adenoviruses contain about 87% protein and 13% DNA (Green and Pina, 1963), while the larger avian chick embryo lethal orphan (CELO) virus consists of 83% protein and 17% DNA (Laver et al., 1971).
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Adenovirus particles have a highly ordered structure and are composed of protein and DNA. Human adenoviruses contain about 87% protein and 13% DNA (Green and Pina, 1963), while the larger avian chick embryo lethal orphan (CELO) virus consists of 83% protein and 17% DNA (Laver et al., 1971).
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