Results 151 to 160 of about 26,875,751 (309)
Molecular Oncology, EarlyView.Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis +20 more
wiley +1 more source
Molecular Oncology, EarlyView.Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi +2 more
wiley +1 more source
Veterinary and Animal ScienceOver centuries, dogs have accompanied human populations during seasonal livestock movements associated with transhumance, contributing to the development of specialized pastoral dog populations.
Christian Persichilli +8 more
doaj +1 more source
Modeling Discrete Survival Time Using Genomic Feature Data
, 2015 Researchers have recently shown that penalized models perform well when applied to high-throughput genomic data. Previous researchers introduced the generalized monotone incremental forward stagewise (GMIFS) method for fitting overparameterized logistic ...
Kellie J. Archer, Kyle Ferber
core +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Frontiers in GeneticsThe National Center Biobank Network (NCBN) is constituted by a network of biobanks from five National Centers and the Japan Institute for Health Security (JIHS). The NCBN primarily collects samples from patients with various diseases, amassing a total of
Yosuke Omae +3 more
doaj +1 more source
Sparse designs for genomic selection using multi-environment data
, 2020 This research study the genomic-enabled prediction accuracy of the composition of the following sparse testing allocation design: (1) all non-overlapping (0 overlapping) lines in environments, (2) all overlapping (0 non-overlapping) lines tested in all ...
Gowda, Manje +8 more
core
Privacy Protection for Genomic Data: Current Techniques and Challenges
, 2010 Human genomic data is a treasure that holds rich information for bioresearch. The share of human genomic data is necessary for the continuous progress of biology, medicine and health research. However, human genomic data also contains private information
Li, Jiuyong +14 more
core +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
Versatile vector tools for efficient protein screening across multiple expression systems
FEBS Open Bio, EarlyView.A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu +5 more
wiley +1 more source