Results 141 to 150 of about 26,875,751 (309)

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Replication Data for: Enhancing Genomic Prediction Accuracy in Precision Breeding through Combined Pedigree and Genomic Matrices

Breeding analyses may include pedigree information and genotypic data. The wheat data in this dataset were used to asssess the accuracy of genomic predictons when the pedigree or genetic similarity matrix is combined with the genomic similarity matrix ...
Cuevas, Jaime, Montesinos-López, Abelardo, Gerard, Guillermo, Saint Pierre, Carolina, Crossa, Jose, Montesinos-López, Osval A., Vitale, Paolo, Crespo Herrera, Leonardo Abdiel, Dreisigacker, Susanne, Otegón, Jaime, Martini, Johannes Wolfgang Robert, Pérez-Rodríguez, Paulino   +11 more
core   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Use of hyperspectral reflectance-derived relationship matrices for genomic prediction of grain yield in wheat - data for publication

, 2018
Genomic, pedigree, grain yield and hyperspectral data for the ...
Mondal, Suchismita, Singh, Ravi, Poland, Jesse, Juliana, Philomin, Dreisigacker, Susanne, Krause, Margaret R.   +5 more
core   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

Molecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani, Laura Mariën, Caro De Weerdt, Sanne Wouters, Laure‐Anne Teuwen, Hans Prenen, Katleen Janssens, Timon Vandamme   +7 more
wiley   +1 more source

Towards equitable governance of human genomic data sharing: guided by genomic contextualism

Data & Policy
This article examines the governance challenges of human genomic data sharing. The analysis builds upon the unique characteristics that distinguish genomic data from other forms of personal data, particularly its dual nature as both uniquely identifiable
Gang Wang
doaj   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Genomic data processing with GenomeFlow

CoRR
Advances in genome sequencing technologies generate massive amounts of sequence data that are increasingly analyzed and shared through public repositories. On-demand infrastructure services on cloud computing platforms enable the processing of such large-scale genomic sequence data in distributed processing environments with a significant reduction in ...
Junseok Park, Eduardo A. Maury, Changhoon Oh, Donghoon Shin, Danielle Denisko, Eunjung Alice Lee   +5 more
openaire   +3 more sources

Replication Data for: Modeling genotype × environment interaction for single and multi-trait genomic prediction in potato (Solanum tuberosum L.)

, 2022
Genomic prediction (GP) can be used in the breeding of polysomic polyploid plant species. Different models can be used to generate the genomic prediction including single trait and multi-trait models.
Ortiz, Rodomiro, Cuevas, Jaime, Reslow, Fredrik, Crossa, Jose   +3 more
core