Results 141 to 150 of about 421,782 (313)

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Contribution of Range‐Wide and Short‐Scale Chemical Soil Variation to Local Adaptation in a Tropical Montane Forest Tree

Evolutionary Applications
Local adaptation is a fundamental process that allows populations to thrive in their native environment, often increasing genetic differentiation with neighboring stands.
Sebastián Arenas, Jorge Cruz‐Nicolás, Gustavo Giles‐Pérez, Josué Barrera‐Redondo, Verónica Reyes‐Galindo, Alicia Mastretta‐Yanes, Erika Aguirre‐Planter, Luis E. Eguiarte, Juan Pablo Jaramillo‐Correa   +8 more
doaj   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Limits and patterns of cytomegalovirus genomic diversity in humans

, 2016
Human cytomegalovirus (HCMV) exhibits surprisingly high genomic diversity during natural infection although little is known about the limits or patterns of HCMV diversity among humans.
Yamamoto, Aparecida Y., Mussi-Pinhata, Marisa M., Hamprecht, Klaus, Pokalyuk, Cornelia, Britt, William J., Bhattacharjee, Bornali, Renzette, Nicholas, Gibson, Laura L, Jensen, Jeffrey D., Schleiss, Mark R., Kowalik, Timothy F.   +10 more
core   +1 more source

Whole-genome sequencing and genomic analysis of four Akkermansia strains newly isolated from human feces

Frontiers in Microbiology
BackgroundNumerous studies have demonstrated that Akkermansia is closely associated with human health. These bacteria colonize the mucus layer of the gastrointestinal tract and utilize mucin as their sole source of carbon and nitrogen.
Wenjing Lu, Biqing Zha, Jie Lyu, Chenxi LingHu, Jing Chen, Sisi Deng, Xiangling Zhang, Liang Li, Guoqing Wang   +8 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Genetic diversity and spread dynamics of SARS-CoV-2 variants present in African populations

Royal Society Open Science
The dynamics of coronavirus disease-19 (COVID-19) have been extensively researched in many settings around the world, but little is known about these patterns in Africa.
Desire Mtetwa, Tafadzwa Manjengwa, Zedias Chikwambi   +2 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Phenotypic and genomic diversity of Lactobacillus plantarum.

, 2006
Lactobacillus plantarum is a ubiquitous micro-organism that is able to colonise several ecological niches, including vegetables, meat, and dairy substrates. In addition, it is applied as a starter culture for food fermentation. Moreover, L. plantarum has
de Vos W. M., Dellaglio F., Tzeneva V. A., CASTIONI, Anna, Zoetendal E. Starrenburg M. J. C., Smidt H., Rademaker J. L. W., Molenaar D., Phan H. T. K., van Hylckama Vlieg J. E. T., TORRIANI, Sandra, Hugenholtz J.   +11 more
core  

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source