Results 151 to 160 of about 421,782 (313)

Nucleotide diversity inside and outside genomic islands for each population.

, 2016
Genomic islands of parallel differentiation (IPDs) show on average a slightly but not significantly higher diversity than both the genomic background and genomic islands of non-parallel differentiation (INDs) in all populations and diversity did not ...
Kay Lucek (299317), David A. Marques (756831), Joana I. Meier (2541316), Catherine E. Wagner (2541319), Ole Seehausen (78039), Laurent Excoffier (5278), Salome Mwaiko (2541313)   +6 more
core   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Genome-Wide Analysis of Genetic Diversity and Selection Signatures in Zaobei Beef Cattle

Animals
This investigation provides a comprehensive analysis of genomic diversity and selection signatures in Zaobei beef cattle, an indigenous breed known for its adaptation to hot and humid climates and superior meat quality.
Liangyu Shi, Pu Zhang, Qing Liu, Chenhui Liu, Lei Cheng, Bo Yu, Hongbo Chen   +6 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Small variable segments constitute a major type of diversity of bacterial genomes at the species level

, 2010
Analysis of large scale diversity in bacterial genomes has mainly focused on elements such as pathogenicity islands, or more generally, genomic islands. These comprise numerous genes and confer important phenotypes, which are present or absent depending ...
El Karoui, Meriem, Valérie Barbe, Marie-Agnès Petit, Meriem El Karoui, Denamur, Erick, Petit, Marie-Agnès, Fabrice Touzain, Barbe, Valérie, Erick Denamur, Médigue, Claudine, Touzain, Fabrice, Claudine Médigue, Petit, Marie Agnès   +12 more
core   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Genomic architecture of human neuroanatomical diversity

, 2015
International audienceHuman brain anatomy is strikingly diverse and highly inheritable: genetic factors may explain up to 80% of its variability. Prior studies have tried to detect genetic variants with a large effect on neuroanatomical diversity, but ...
Heinz, A, B�chel, C, Smolka, M, N, Bourgeron, T., Garavan, H, Lawrence, C, Paus, T, Poline, J-B, Schumann, G., Rietschel, M, Toro, R, Smolka, M N, Barker, G J; id_orcid, Barker, G,, Nees, F, Fauth-Bühler, M, ?, ?, Banaschewski, T, Lema�tre, H, Pausova, Z, Robbins, T, Frouin, V., Heinz, A., Fauth-B�hler, M, Büchel, C, Gallinat, J, Loth, E, Bourgeron, T, Smolka, M,, Toro, Roberto, Gowland, P, Conrod, P, Ittermann, B, Carvalho, F.M., Barker, G J, Mann, K., Mann, K, Str�hle, A, Banaschewski, T., Lemaître, H, Bokde, A, Carvalho, F M, Barker, G, J, Loth, E; id_orcid, Schumann, G, Frouin, V, Flor, H, Ströhle, A, Huguet, G   +48 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Pectobacterium punjabense Causing Blackleg and Soft Rot of Potato: The First Report in the Russian Federation

Plants
Phytopathogenic bacteria of the genus Pectobacterium are responsible for several diseases that affect potato (Solanum tuberosum L.) production worldwide, including blackleg and tuber soft rot.
Anna A. Vasilyeva, Peter V. Evseev, Alexandr N. Ignatov, Fevzi S.-U. Dzhalilov   +3 more
doaj   +1 more source