3D‐Printed Scaffolds Promote Enhanced Spinal Organoid Formation for Use in Spinal Cord Injury
3D‐printed organoid scaffolds with microscale channels are developed to enhance spinal cord injury recovery by guiding region‐specific spinal neural progenitor cells. These scaffolds promote axonal growth, cell maturation, and neuronal network formation.
Guebum Han+8 more
wiley +1 more source
RAD51 plays critical roles in DNMT1-mediated maintenance methylation of genomic DNA by dually regulating the ubiquitin ligase UHRF1. [PDF]
Liu G+6 more
europepmc +1 more source
Disparate pathways for extrachromosomal DNA biogenesis and genomic DNA repair
Rose JC+8 more
europepmc +1 more source
This study develops a 3D vascular injury model using a microphysiological system that mimics key features of intimal hyperplasia. Antiproliferative drugs reduced VSMC proliferation but worsened endothelialdenudation. A combination of diphenyleneiodonium and quercetin effectively reduced proliferation and migration of VSMC and inflammation while ...
Ungsig Nam+7 more
wiley +1 more source
Method for isolation of high molecular weight genomic DNA from Botryococcus biomass. [PDF]
Cornejo-Corona I+2 more
europepmc +1 more source
Integration of Bioengineered Tools in Assisted Reproductive Technologies
A conceptual illustration depicting the collaboration between a medical professional (right) and a scientist (left). Their connection highlights the integration of scientific research and clinical practice. This representation underscores the role of emerging technologies in bridging fundamental research with applied reproductive healthcare.
Aslı Ak+3 more
wiley +1 more source
Improved metagenome assemblies through selective enrichment of bacterial genomic DNA from eukaryotic host genomic DNA using ATAC-seq. [PDF]
Cantin LJ, Dunning Hotopp JC, Foster JM.
europepmc +1 more source
Lymphoid and CXCR4 Cell Targeted Lipid Nanoparticles Facilitate HIV‐1 Proviral DNA Excision
Advancements in ART improve HIV‐1 patient outcomes but are unable to eliminate latent viral DNA. To address this, CXCR4‐targeted lipid nanoparticles (T‐LNPs) for delivering CRISPR‐Cas9 to excise HIV‐1 DNA in infected cells are developed. These T‐LNPs achieve ≈60% HIV‐1 DNA excision efficacy in blood and splenic tissue, demonstrating promise for ...
Sudipta Panja+6 more
wiley +1 more source
Cultivation and Genomic DNA Extraction of Klebsiella pneumoniae. [PDF]
Pariseau DA, Ring BE, Khadka S, Mike LA.
europepmc +1 more source