Results 281 to 290 of about 1,762,314 (335)

An Organ‐on‐Chip Platform for Strain‐Controlled, Tissue‐Specific Compression of Cartilage and Mineralized Osteochondral Interface to Study Mechanical Overloading in Osteoarthritis

Advanced Healthcare Materials, EarlyView.
A mechanically active OsteoChondral Unit (OCU)‐on‐Chip platform mimicking the OCU's functional anatomy and the strain gradient across the osteochondral interface is presented. Upon compartment‐specific hyperphysiological compression, the model replicates mechanisms observed in osteoarthritis (OA) progression, such as calcium crystal accumulation ...
Andrea Mainardi, Anastasiya Börsch, Paola Occhetta, Robert Ivanek, Martin Ehrbar, Lisa Krattiger, Philipp Oertle, Marko Loparic, Ivan Martin, Marco Rasponi, Andrea Barbero   +10 more
wiley   +1 more source

Analyzing Cell-free Genomic DNA in Spent Culture Media: Noninvasive Insight into the Blastocysts. [PDF]

Glob Med Genet
Layek SS, Kanani S, Doultani S, Gohil T, Patil S, Sudhakar A, Raval KB, Kuppusamy K, Gorani S, Raj S, Sangameshwari R, Jadeja H, P MM.   +12 more
europepmc   +1 more source

The Rise of Mechanobiology for Advanced Cell Engineering and Manufacturing

Advanced Materials, EarlyView.
With the growing demand for cell‐based therapies, efficient cellular engineering is crucial. This review calls for greater recognition of mechanobiology principles applied through advanced biomaterial designs, mechanical confinement, and highlights recent advances using micro/nanotechnologies to enhance cell manufacturing.
Huan Ting Ong, M Sriram, Hepi Hari Susapto, Yixuan Li, Yuan Jiang, Nicolas H. Voelcker, Jennifer L. Young, Andrew W. Holle, Roey Elnathan   +8 more
wiley   +1 more source

A biospecies-derived genomic DNA hybrid gel electrolyte for electrochemical energy storage. [PDF]

PNAS Nexus
Mitta SB, Kim J, Rana HH, Kokkiligadda S, Lim YT, Bhang SH, Park HS, Um SH.   +7 more
europepmc   +1 more source

Designing the Next Generation of Biomaterials through Nanoengineering

Advanced Materials, EarlyView.
Nanoengineering enables precise control over biomaterial interactions with living systems by tuning surface energy, defects, porosity, and crystallinity. This review highlights how these nanoscale design parameters drive advances in regenerative medicine, drug delivery, bioprinting, biosensing, and bioimaging, while outlining key translational ...
Ryan Davis Jr., Ishaan Duggal, Nicholas A. Peppas, Akhilesh K. Gaharwar   +3 more
wiley   +1 more source

Detection rate for ESR1 mutations is higher in circulating-tumor-cell-derived genomic DNA than in paired plasma cell-free DNA samples as revealed by ddPCR. [PDF]

Mol Oncol
Smilkou S, Ntzifa A, Tserpeli V, Balgkouranidou I, Papatheodoridi A, Razis E, Linardou H, Papadimitriou C, Psyrri A, Zagouri F, Kakolyris S, Lianidou E.   +11 more
europepmc   +1 more source

Artesunate Nanoplatform Targets the Serine–MAPK Axis in Cancer‐Associated Fibroblasts to Reverse Photothermal Resistance in Triple‐Negative Breast Cancer

Advanced Materials, EarlyView.
The artesunate nanoplatform selectively targets ECM CAF, functioning as a GTPase inhibitor through disruption of intracellular serine homeostasis. This metabolic intervention effectively suppresses MAPK cascade activity, which consequently inhibits PTT‐induced CAF to ECM CAF differentiation.
Dongdong Zheng, Jiaqi Yan, Xuejiao Liu, Zhiming Zhang, Anqi Jin, Yue Zhao, Lu Bai, Mengyao Quan, Xiuzhu Qi, Bin Fu, Zhigang Wu, Jin Zhou, Han Han, Ziqi Wang, Shiyu Wang, Chaoqiang Deng, Weijian Sun, Cai Chang, Shichong Zhou, Hongbo Zhang   +19 more
wiley   +1 more source

Protocol for iterative enrichment of integrated sgRNAs via derivative CRISPR-Cas9 libraries from genomic DNA of sorted fixed cells. [PDF]

STAR Protoc
Ordóñez A, Ron D, Harding HP.
europepmc   +1 more source

The Role of Artificial Intelligence in Advancing Biosensor Technology: Past, Present, and Future Perspectives

Advanced Materials, EarlyView.
This review explores the transformative role of AI in biosensor technology and provides a holistic interdisciplinary perspective that covers a broader scope of AI‐enabled biosensor technologies across various sectors including healthcare, environmental monitoring, food safety, and agriculture. It also highlights the important role of novel materials in
Tuğba Akkaş, Mahshid Reshadsedghi, Mustafa Şen, Volkan Kılıç, Nesrin Horzum   +4 more
wiley   +1 more source

Alpha-synuclein modulates the repair of genomic DNA double-strand breaks in a DNA-PK_cs-regulated manner. [PDF]

Neurobiol Dis
Rose EP, Osterberg VR, Gorbunova V, Unni VK.   +3 more
europepmc   +1 more source