Preparation of enteroinvasive Escherichia coli reference materials for food analysis
Zhongguo shipin weisheng zazhi, 2021 ObjectiveTo satisfy the demands of laboratory quality control and proficiency testing for the detection of enteroinvasive Escherichia coli (EIEC), a stable EIEC reference material was developed with independent intellectual property rights, good ...
ZHAO Linna +4 more
doaj +1 more source
MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA [PDF]
, 2012 Topoisomerase II creates a double-strand break intermediate with topoisomerase covalently coupled to the DNA via a 5'-phosphotyrosyl bond. These intermediate complexes can become cytotoxic protein-DNA adducts and DSB repair at these lesions requires ...
Austin, Caroline +10 more
core +3 more sources
The Adaptive Significance of Natural Genetic Variation in the DNA Damage Response of Drosophila melanogaster. [PDF]
, 2016 Despite decades of work, our understanding of the distribution of fitness effects of segregating genetic variants in natural populations remains largely incomplete. One form of selection that can maintain genetic variation is spatially varying selection,
Begun, David J +3 more
core +4 more sources
Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism
Nature Communications, 2017 Glutaminase inhibition (GLSi) has promising activity against certain cancers. Here, the authors show that GLSi has no effect on multiple mouse models of pancreatic cancer and characterize the metabolic pathways activated in response to GLSi whose ...
Douglas E. Biancur +12 more
doaj +1 more source
NCOA4 maintains murine erythropoiesis via cell autonomous and non-autonomous mechanisms
Haematologica, 2019 Ncoa4 mediates autophagic degradation of ferritin, the cytosolic iron storage complex, to maintain intracellular iron homeostasis. Recent evidence also supports a role for Ncoa4 in systemic iron homeostasis and erythropoiesis.
Naiara Santana-Codina +11 more
doaj +1 more source
Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis
Nature Communications, 2018 Pancreatic ductal adenocarcinoma (PDAC) cells display varying degrees of reliance on oncogenic KRAS. Here the authors show that KRAS-resistant PDAC cells maintain nucleotides synthesis through a KRAS-independent upregulation of the non-oxidative pentose ...
Naiara Santana-Codina +10 more
doaj +1 more source
Preliminary study of familial nonsyndromic tooth agenesis caused by ectodysplasin A mutation
口腔疾病防治, 2023 Objective To explore the pathogenic genes in a Chinese family affected by nonsyndromic tooth agenesis so as to study the pathogenesis of oligodontia. Methods Hospital ethical approval and informed consent of the patients and family members were obtained.
WANG Huihui +4 more
doaj +1 more source
Optimization of high molecular weight DNA extraction methods in shrimp for a long-read sequencing platform [PDF]
PeerJ, 2020 Marine organisms are important to global food security as they are the largest source of animal proteins feeding mankind. Genomics-assisted aquaculture can increase yield while preserving the environment to ensure sufficient and sustainable production ...
Pacharaporn Angthong +11 more
doaj +2 more sources
The Role of NCOA4-Mediated Ferritinophagy in Health and Disease
Pharmaceuticals, 2018 Nuclear receptor coactivator 4 (NCOA4) is a selective cargo receptor that mediates the autophagic degradation of ferritin (“ferritinophagy„), the cytosolic iron storage complex.
Naiara Santana-Codina, Joseph D. Mancias
doaj +1 more source
Journal of Biological Chemistry, 2014 Background: Exosomes are small vesicles in the tumor microenvironment containing nucleic acids and proteins with the capacity to influence cell behavior. Results: Exosomes contain double-stranded genomic DNA.
C. Kahlert +10 more
semanticscholar +1 more source