Results 21 to 30 of about 1,062,471 (320)
NCOA4 maintains murine erythropoiesis via cell autonomous and non-autonomous mechanisms
Haematologica, 2019 Ncoa4 mediates autophagic degradation of ferritin, the cytosolic iron storage complex, to maintain intracellular iron homeostasis. Recent evidence also supports a role for Ncoa4 in systemic iron homeostasis and erythropoiesis.
Naiara Santana-Codina +11 more
doaj +1 more source
Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis
Nature Communications, 2018 Pancreatic ductal adenocarcinoma (PDAC) cells display varying degrees of reliance on oncogenic KRAS. Here the authors show that KRAS-resistant PDAC cells maintain nucleotides synthesis through a KRAS-independent upregulation of the non-oxidative pentose ...
Naiara Santana-Codina +10 more
doaj +1 more source
DNA repair: Caretakers of the genome? [PDF]
Current Biology, 1997 Recent results show that the 8-oxoguanine DNA repair system is functionally conserved in bacteria and mammals. The bacterial system protects the genome from the mutagenic effects of oxidative stress; the role of the mammalian system is expected to be similar and defects in it may increase susceptibility to cancer.
openaire +3 more sources
The Role of NCOA4-Mediated Ferritinophagy in Health and Disease
Pharmaceuticals, 2018 Nuclear receptor coactivator 4 (NCOA4) is a selective cargo receptor that mediates the autophagic degradation of ferritin (“ferritinophagy„), the cytosolic iron storage complex.
Naiara Santana-Codina, Joseph D. Mancias
doaj +1 more source
Harnessing sponge gourd: an alternative source of oil and protein for nutritional security
Frontiers in Nutrition, 2023 Luffa cylindrica (L.) Roem. is an important cucurbit crop that assures food security and dietary diversity among the poor communities. In the present study, seeds of 42 genotypes of Luffa cylindrica were evaluated for their potential use as oil seed crop.
Ruchi Tyagi +7 more
doaj +1 more source
Veterinární Medicína, 2016 : The objective of this study was to evaluate a combined antibiotic-enzyme therapy for Staphylococcus aureus mastitis and biofilm formation. A total of 141 cases of S.
B. Khoramian +6 more
doaj +1 more source
Nonspecific transcription factor-DNA binding influences nucleosome occupancy in yeast [PDF]
Biophysical Journal, Volume 101, Issue 10, 2465-2475 (2011), 2011 Quantitative understanding of the principles regulating nucleosome occupancy on a genome-wide level is a central issue in eukaryotic genomics. Here, we address this question using budding yeast, Saccharomyces cerevisiae, as a model organism. We perform a genome-wide computational analysis of nonspecific transcription factor (TF)-DNA binding free energy
arxiv +1 more source
Mitochondrial DNA: A disposable genome?
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2015 In mammalian cells, mitochondria are the only organelles besides the nucleus that house genomic DNA. The mammalian mitochondrial genome is represented by prokaryotic-type, circular, highly compacted DNA molecules. Today, more than a half-century after their discovery, the biology of these small and redundant molecules remains much less understood than ...
Shokolenko, Inna N. +1 more
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DNA methylation of cancer genome [PDF]
Birth Defects Research Part C: Embryo Today: Reviews, 2009 AbstractDNA methylation plays an important role in regulating normal development and carcinogenesis. Current understanding of the biological roles of DNA methylation is limited to its role in the regulation of gene transcription, genomic imprinting, genomic stability, and X chromosome inactivation.
Wai-Yee Chan +4 more
openaire +3 more sources
BioTechniques, 2023 High-quality genomic DNA extraction is fundamental for the study of gene cloning and expression in plants. Therefore, this study evaluated several methods for extracting genomic DNA from shoots of four Dendrocalamus species to determine the optimal ...
Yingchun Ma +6 more
doaj +1 more source