Results 191 to 200 of about 1,050,824 (300)

Transforming the Landscape of Drug Innovation in AI Era: AlphaFold 3 and Beyond

Exploration, EarlyView.
Traditional drug development is time‐consuming and costly, and new tools are urgently needed to improve efficiency. This perspective reviews the considerable potential of AlphaFold 3 as a next‐generation predictive tool for drug discovery, particularly in target identification and validation, hit identification and lead optimization, and personalized ...
Songlin He, Liangbin Zhou, Xiaoshuai Wang, Chenzhong Li, Cheng Jiang, Rocky S. Tuan, Zhong Alan Li   +6 more
wiley   +1 more source

Genomic epidemiology of the 2025 mpox epidemic in Sierra Leone. [PDF]

Nat Med
Campbell AKO, Sandi JD, Omah IF, Faye M, Parker E, Brock-Fisher T, Gigante CM, Folorunso V, Kamara MS, Williams AJ, Kane M, Kallon TMPS, Campbell J, Sesay KS, Mani S, Miller C, Sesay ND, Baimba F, Ndiaye M, Lansana R, Fofanah IU, Ruhweza S, Souma Z, Kargbo A, Koninga K, Tia A, Ngobeh J, Thoronka F, Fofanah A, Ozonoff A, Wilkason C, Park D, Tomkins-Tinch C, Paye MF, Shin C, Baudi I, Blumenstiel B, Varilly P, Specht I, Fry B, Zhao K, Cronan P, Laning E, Ope-Ewe OO, Sijuwola AE, Saibu F, Soumare H, Ogundana EK, Obaado RO, Adole JA, Kio IK, Njeandoh FA, Tuttle A, Oguta WO, Greene J, Koroma A, Kanu J, Barry MA, Gaye A, Diouf AM, Hughes C, Levy JI, N'jai A, Diagne MM, Nosamiefan D, Ameh G, Klena J, Foster MA, Kebede A, Tanui C, Diallo B, Happi A, Tessema S, Sow A, Kebede Y, Wurie I, Squire J, Harding D, Koroma Z, Jalloh MB, Sall AA, Andersen KG, Rambaut A, Vandi MA, Fall IS, Sabeti P, Happi C, Sahr F, Grant DS.   +88 more
europepmc   +1 more source

Multi‐Cohort Analysis Reveals Genetic Predispositions to Clonal Hematopoiesis as Mutation‐Specific Risk Factors for Stroke

Advanced Genetics, Volume 6, Issue 1, March 2025.
This study comprehensively evaluated the differential effect of clonal hematopoiesis (CH) mutations on the risk of various stroke subtypes and functional recovery. It shows that TET2 is associated with small vessel stroke possibly via a pro‐inflammatory pathway. Abstract Recent observational studies have found an association between Clonal Hematopoesis
Shuyang Lin, Yang E. Li, Yan Wang
wiley   +1 more source

Genomic epidemiology of coxsackievirus A24 variant during the 2024 acute hemorrhagic conjunctivitis outbreak in Coastal Kenya. [PDF]

PLoS Pathog
Morobe JM, Ong'era EM, Lambisia AW, Odoyo SO, Mutunga M, Katama EN, Cheruiyot R, Nyiro JU, Kamau E, Houldcroft CJ, Keeling M, Gallagher K, Holmes EC, Agoti CN.   +13 more
europepmc   +1 more source

Reframing Technology and Ethics in Corneal Xenotransplantation: A Scoping Review of Standards and Safety in Ophthalmology

Health Care Science, EarlyView.
Bringing attention to the moral dilemmas raised by xenotransplantation and the continuous creation of standardized frameworks for donor technology and biosafety risk management, with a focus on striking a balance between patient safety, medical innovation, and ethical obligation.
Sankhajyoti Saha, Moubani Dutta, Agnihiya Bosu   +2 more
wiley   +1 more source

Genomic epidemiology, evolution, and transmission dynamics of porcine sapelovirus associated with diarrheic piglets. [PDF]

Virulence
Li X, Ma XA, Wang X, Li Q, Yuan Q, Wang J, Bai H, Liu Y, Zhao F.   +8 more
europepmc   +1 more source

Unravelling the genomic epidemiology and antigenic evolution of Chandipura virus: A genetically constrained neurotropic threat. [PDF]

PLoS Negl Trop Dis
Kuri PR, Sharma A.
europepmc   +1 more source

Genomic epidemiology of multidrug-resistant and ESBL-producing Proteus mirabilis in a military referral hospital in Ethiopia. [PDF]

PLoS One
Yusuf YM, Desta AF, Ayana D, Aychegrew HN, Abubeker R, Samson B, Sura T, Gebreegziabxier A, Negeri AA, Bashea C, Getu M, Gebremichael G, Mihret A, Kidane E, Mezgebu E, Sebri S, Tadesse G, Tollera G, Ali A, Woldemichael GB.   +19 more
europepmc   +1 more source

Genomic Epidemiology and Plasmid-Mediated Dissemination of Carbapenem-Resistant <i>Klebsiella pneumoniae</i> in a Tertiary Hospital. [PDF]

Infect Drug Resist
Zhang H, Wang Y, Mao C, Cui W, Fan F, Jiang Y, Han J.   +6 more
europepmc   +1 more source

Genomic epidemiology reveals the origins and transmission dynamics of chikungunya virus in China. [PDF]

Infect Dis Poverty
Chang W, Zheng M, Jiang Y, Liu G, Chen X, Wang X, Guo Y, Liu L, Feng Y, Xia X.   +9 more
europepmc   +1 more source