Results 201 to 210 of about 1,050,824 (300)

Germline Cancer Predisposition and De Novo Contributions in Pediatric Rhabdomyosarcoma: A Report From the Children's Oncology Group

International Journal of Cancer, EarlyView.
ABSTRACT Approximately 6%–8% of children and adolescents with rhabdomyosarcoma (RMS) have an underlying cancer predisposition disorder (CPD), which varies between embryonal and alveolar subtypes and other clinical characteristics. Identifying a CPD remains challenging, as traditional approaches rely on clinical features and family history. Additionally,
Taylor M. Luckie, Sarah Scollon, Yao Yu, Aniko Sabo, Tiffany Chambers, Olga Taylor, Logan G. Spector, Michael E. Scheurer, Douglas S. Hawkins, Rajkumar Venkatramani, Chad D. Huff, Sharon E. Plon, Philip J. Lupo   +12 more
wiley   +1 more source

Prolonged bacterial carriage and hospital transmission detected by whole genome sequencing surveillance

Antimicrobial Stewardship & Healthcare Epidemiology
Alexander J. Sundermann, Marissa P. Griffith, Vatsala Rangachar Srinivasa, Kady Waggle, Graham M. Snyder, Daria Van Tyne, Lora Pless, Lee H. Harrison   +7 more
doaj   +1 more source

Genomic epidemiology of <i>Streptococcus pneumoniae</i> reveals globally disseminated lineages and capsular switching in the Arabian Gulf region. [PDF]

Front Cell Infect Microbiol
Senok A, Verma S, Mohamed L, Kaambo E, Boucherabine S, Senghore M, Nabi A, Habous M, Jabeen F, Alatoom A, Abdulrazzaq N, Moradigaravand D, Jamal W, Nassar R, Mokaddas E, Everett DB.   +15 more
europepmc   +1 more source

Toward Objective Anal Cancer Screening: From Swab‐Based Genome‐Wide Methylation Marker Discovery to Novel Test Development

International Journal of Cancer, EarlyView.
ABSTRACT Anal high‐grade squamous intraepithelial lesions (HSIL:AIN2/3) are precursors to anal cancer, and early detection and treatment through screening is crucial for effective cancer prevention. Current guidelines recommend anal swab‐based screening and highlight the need for objective biomarkers to improve risk stratification.
Kirsten Rozemeijer, Jürgen Claesen, Fernando Dias Gonçalves Lima, Albertus T. Hesselink, Phoebe Klingers, Timo ter Braak, Yara van den Burgt, Chris J. L. M. Meijer, Jan M. Prins, Henry J. C. de Vries, Mark A. van de Wiel, Renske D. M. Steenbergen   +11 more
wiley   +1 more source

Genomic Epidemiology of Antibiotic-Resistant Bacteria Sampled from Metropolitan Wastewater. [PDF]

Microorganisms
Deslouches JT, Raabe NJ, Mills EG, Fleres G, Wallace NR, Yassin MH, Van Tyne D.   +6 more
europepmc   +1 more source

Epigenetic Predictors of Smoking: External Validation and Association With Smoking‐Related Cancer Risk

International Journal of Cancer, EarlyView.
ABSTRACT Tobacco smoking has a strong influence on DNA methylation (DNAm), enabling the development of DNAm‐based smoking predictors, yet external evaluations of these have remained limited. We aimed to assess six DNAm‐based smoking predictors in a large sample of middle‐aged and older Australians for (i) their accuracy and reliability, and (ii) their ...
Xiaoyu Fan, Danmeng Lily Li, Allison M. Hodge, Julie K. Bassett, Nina Afshar, Melissa C. Southey, Graham G. Giles, Roger L. Milne, Pierre‐Antoine Dugué   +8 more
wiley   +1 more source

Respiratory virus genomic epidemiology during post-pandemic re-emergence of influenza in Australia. [PDF]

Virus Evol
Rockett RJ, Agius JE, Chandra S, Fong W, Aziz A, Suster CJE, Basile K, Lam C, Chen SC, Dwyer DE, Kok J, Sullivan SG, Barr IG, Sintchenko V, Golubchik T.   +14 more
europepmc   +1 more source

High‐Grade B‐Cell Lymphoma With 11q Aberration in Africa: A Differential Diagnosis in Cases With Features of Endemic Burkitt Lymphoma

International Journal of Cancer, EarlyView.
ABSTRACT Fifty years ago, Zech et al. in this journal described for the first time the t(8;14) as a recurrent chromosomal aberration in Burkitt lymphoma (BL). Nevertheless, in regions where BL is not endemic, a subset of lymphomas with features of BL lacks the t(8;14)/IG::MYC and instead represents high‐grade B‐cell lymphoma with 11q aberration (HGBCL ...
Timothy Onyuma, Anja Fischer, Raffaella Guazzo, Mateus H. Gouveia, Noel Onyango, Cristiana Bellan, Susanne Bens, Roberto Boccacci, Michaela Feuring, Massimo Granai, Grace Kiraka, Alexandra G. Kouroukli, Stefano Lazzi, Cosimo Lori, Marianne Wanjiru Mureithi, Joshua Nyagol, Matthias Schlesner, Maria Chiara Siciliano, Margherita Vannucchi, Rabea Wagener, Nicholas Othieno‐Abinya, Sam M. Mbulaiteye, Lorenzo Leoncini, Reiner Siebert   +23 more
wiley   +1 more source

Genomic epidemiology of carbapenemase-producing <i>Enterobacter cloacae</i> complex in Argentina: a retrospective analysis (2016-2022). [PDF]

Microbiol Spectr
de Mendieta JM, Menocal MA, Sanz MB, De Belder D, Rapoport M, Poklepovich T, Pasteran F, Corso A, Gomez SA.   +8 more
europepmc   +1 more source

MLH1 p.His112Arg Variant Is Associated With Increased Cancer Susceptibility

International Journal of Cancer, EarlyView.
ABSTRACT Lynch syndrome, a prevalent hereditary cancer predisposition, is frequently caused by pathogenic variants in the MutL homolog 1 (MLH1) mismatch repair gene. However, a significant proportion of MLH1 missense variants remain classified as variants of uncertain significance (VUS), creating clinical ambiguity.
Amal Elfatih, Issam Tout, Najwa Ahmad Doha, Tala Abu Arja, Idris Mohammed, Doua Abdelrhaman, Waseem Hasan, Chadi Saad, Hamdi Mbarek, Borbala Mifsud, Sahar Isa Da'as   +10 more
wiley   +1 more source