Results 31 to 40 of about 131,595 (265)

Robustness in quantifying the abundance of antimicrobial resistance genes in pooled faeces samples from batches of slaughter pigs using metagenomics analysis

Journal of Global Antimicrobial Resistance, 2021
Objectives: With the continued spread of antimicrobial resistance (AMR) in animals, it is important to assess its occurrence throughout a microbiome quantitatively in order to evaluate significantly affecting factors, e.g.
Vibe Dalhoff Andersen, Marie Stengaard Jensen, Patrick Munk, Håkan Vigre   +3 more
doaj   +1 more source

Mendelian randomization of circulating proteome identifies actionable targets in heart failure

BMC Genomics, 2022
Background Heart failure (HF) is a prevalent cause of mortality and morbidity. The molecular drivers of HF are still largely unknown. Results We aimed to identify circulating proteins causally associated with HF by leveraging genome-wide genetic ...
Louis-Hippolyte Minvielle Moncla, Samuel Mathieu, Mame Sokhna Sylla, Yohan Bossé, Sébastien Thériault, Benoit J. Arsenault, Patrick Mathieu   +6 more
doaj   +1 more source

Enhanced discrimination of Clostridioides difficile transmission using whole-genome sequencing and in silico multi-locus variable number tandem repeat analysis

Microbiology Spectrum
Whole-genome sequencing (WGS) is used to establish genetic relatedness of bacteria and track outbreaks in healthcare settings. While WGS provides sufficient discriminatory power to make inferences about genetic relatedness and transmission for most ...
Alexander J. Sundermann, Emma G. Mills, Vatsala Rangachar Srinivasa, Marissa P. Griffith, Deena Ereifej, Kady D. Waggle, Nathan J. Raabe, Graham M. Snyder, Daria Van Tyne, Lora Lee Pless, Lee H. Harrison   +10 more
doaj   +1 more source

Genomic Epidemiology with Mixed Samples [PDF]

, 2020
AbstractGenomic epidemiology is a tool for tracing transmission of pathogens based on whole-genome sequencing. We introduce the mGEMS pipeline for genomic epidemiology with plate sweeps representing mixed samples of a target pathogen, skipping the colony pick step.
Tommi Mäklin, Teemu Kallonen, Jarno Alanko, Ørjan Samuelsen, Kristin Hegstad, Veli Mäkinen, Jukka Corander, Eva Heinz, Antti Honkela   +8 more
openaire   +1 more source

Vaccine prevention of meningococcal disease in Africa: Major advances, remaining challenges

Human Vaccines & Immunotherapeutics, 2018
Africa historically has had the highest incidence of meningococcal disease with high endemic rates and periodic epidemics. The meningitis belt, a region of sub-Saharan Africa extending from Senegal to Ethiopia, has experienced large, devastating ...
Mustapha M. Mustapha, Lee H. Harrison
doaj   +1 more source

Microbiota long-term dynamics and prediction of acute graft-versus-host disease in pediatric allogeneic stem cell transplantation

Microbiome, 2021
Background Patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) exhibit changes in their gut microbiota and are experiencing a range of complications, including acute graft-versus-host disease (aGvHD). It is unknown if, when, and
Anna Cäcilia Ingham, Katrine Kielsen, Hanne Mordhorst, Marianne Ifversen, Frank M. Aarestrup, Klaus Gottlob Müller, Sünje Johanna Pamp   +6 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Transmission of antimicrobial resistance in the gut microbiome of gregarious cockroaches: the importance of interaction between antibiotic exposed and non-exposed populations

mSystems
Antimicrobial resistance (AMR) is a major global health concern, further complicated by its spread via the microbiome bacterial members. While mathematical models discuss AMR transmission through the symbiotic microbiome, experimental studies are scarce.
Amalia Bogri, Emilie Egholm Bruun Jensen, Asbjørn Vedel Borchert, Christian Brinch, Saria Otani, Frank M. Aarestrup   +5 more
doaj   +1 more source

The Relevance of Genomic Epidemiology for Control of Tuberculosis in West Africa

Frontiers in Public Health, 2021
Tuberculosis (TB), an airborne infectious disease caused by Mycobacterium tuberculosis complex (MTBC), remains a global health problem. West Africa has a unique epidemiology of TB that is characterized by medium- to high-prevalence.
Prince Asare, Adwoa Asante-Poku, Stephen Osei-Wusu, Isaac Darko Otchere, Dorothy Yeboah-Manu   +4 more
doaj   +1 more source

Shared Genetic Effects and Antagonistic Pleiotropy Between Multiple Sclerosis and Common Cancers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epidemiologic studies have reported inconsistent altered cancer risk in individuals with multiple sclerosis (MS). Factors such as immune dysregulation, comorbidities, and disease‐modifying therapies may contribute to this variability.
Asli Buyukkurt, Marius Ygonia, Ali Manouchehrinia, Philippe Lefrançois, Ingrid Kockum, Adil Harroud   +5 more
wiley   +1 more source