Results 41 to 50 of about 1,050,824 (300)

Mendelian randomization of circulating proteome identifies actionable targets in heart failure

BMC Genomics, 2022
Background Heart failure (HF) is a prevalent cause of mortality and morbidity. The molecular drivers of HF are still largely unknown. Results We aimed to identify circulating proteins causally associated with HF by leveraging genome-wide genetic ...
Louis-Hippolyte Minvielle Moncla, Samuel Mathieu, Mame Sokhna Sylla, Yohan Bossé, Sébastien Thériault, Benoit J. Arsenault, Patrick Mathieu   +6 more
doaj   +1 more source

Robustness in quantifying the abundance of antimicrobial resistance genes in pooled faeces samples from batches of slaughter pigs using metagenomics analysis

Journal of Global Antimicrobial Resistance, 2021
Objectives: With the continued spread of antimicrobial resistance (AMR) in animals, it is important to assess its occurrence throughout a microbiome quantitatively in order to evaluate significantly affecting factors, e.g.
Vibe Dalhoff Andersen, Marie Stengaard Jensen, Patrick Munk, Håkan Vigre   +3 more
doaj   +1 more source

Sequencing data: A genomic network to monitor Earth

, 2012
We propose that a network of genomic observatories should be established to take the planet's 'biological pulse'. We invite participants to assist in the shaping of this network (see genomicobservatories.org).
Field, D., The Genomic Observatories Network, Neil Davies, Hirsch, P. R., The Genomic Observatories Network, ., Davies, N., Field, Dawn, Bates, N., Dawn Field, Davies, Neil, Hirsch, Penny   +10 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Genomic epidemiology of artemisinin resistant malaria [PDF]

eLife, 2016
The current epidemic of artemisinin resistant Plasmodium falciparum in Southeast Asia is the result of a soft selective sweep involving at least 20 independent kelch13 mutations. In a large global survey, we find that kelch13 mutations which cause resistance in Southeast Asia are present at low frequency in Africa.
Amato, R, Miotto, O, Woodrow, CJ, Almagro-Garcia, J, Sinha, I, Campino, S, Mead, D, Drury, E, Kekre, M, Sanders, M, Amambua-Ngwa, A, Amaratunga, C, Amenga-Etego, L, Andrianaranjaka, V, Apinjoh, T, Ashley, E, Auburn, S, Awandare, GA, Baraka, V, Barry, A, Boni, MF, Borrmann, S, Bousema, T, Branch, O, Bull, PC, Chotivanich, K, Conway, DJ, Craig, A, Day, NP, Djimde, A, Dolecek, C, Dondorp, AM, Drakeley, C, Duffy, P, Echeverry, DF, Egwang, TG, Fairhurst, RM, Faiz, MA, Fanello, CI, Tran, TH, Hodgson, A, Imwong, M, Ishengoma, D, Lim, P, Lon, C, Marfurt, J, Marsh, K, Mayxay, M, Michon, P, Mobegi, V, Mokuolu, OA, Montgomery, J, Mueller, I, Kyaw, MP, Newton, PN, Nosten, F, Noviyanti, R, Nzila, A, Ocholla, H, Oduro, A, Onyamboko, M, Ouedraogo, J-B, Phyo, APP, Plowe, C, Price, RN, Pukrittayakamee, S, Randrianarivelojosia, M, Ringwald, P, Ruiz, L, Saunders, D, Shayo, A, Siba, P, Takala-Harrison, S, Thanh, T-NN, Thathy, V, Verra, F, Wendler, J, White, NJ, Ye, H, Cornelius, VJ, Giacomantonio, R, Muddyman, D, Henrichs, C, Malangone, C, Jyothi, D, Pearson, RD, Rayner, JC, McVean, G, Rockett, KA, Miles, A, Vauterin, P, Jeffery, B, Manske, M, Stalker, J, Maclnnis, B, Kwiatkowski, DP   +95 more
openaire   +7 more sources

Transmission of antimicrobial resistance in the gut microbiome of gregarious cockroaches: the importance of interaction between antibiotic exposed and non-exposed populations

mSystems
Antimicrobial resistance (AMR) is a major global health concern, further complicated by its spread via the microbiome bacterial members. While mathematical models discuss AMR transmission through the symbiotic microbiome, experimental studies are scarce.
Amalia Bogri, Emilie Egholm Bruun Jensen, Asbjørn Vedel Borchert, Christian Brinch, Saria Otani, Frank M. Aarestrup   +5 more
doaj   +1 more source

Vaccine prevention of meningococcal disease in Africa: Major advances, remaining challenges

Human Vaccines & Immunotherapeutics, 2018
Africa historically has had the highest incidence of meningococcal disease with high endemic rates and periodic epidemics. The meningitis belt, a region of sub-Saharan Africa extending from Senegal to Ethiopia, has experienced large, devastating ...
Mustapha M. Mustapha, Lee H. Harrison
doaj   +1 more source

e3SIM: Epidemiological-ecological-evolutionary simulation framework for genomic epidemiology. [PDF]

Methods Ecol Evol
Infectious disease dynamics are driven by the complex interplay of epidemiological, ecological, and evolutionary processes. Accurately modeling these interactions is crucial for understanding pathogen spread and informing public health strategies.
Xu P, Liang S, Hahn A, Zhao V, Lo WT', Haller BC, Sobkowiak B, Chitwood MH, Colijn C, Cohen T, Rhee KY, Messer PW, Wells MT, Clark AG, Kim J.   +14 more
europepmc   +3 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Public health genomics and the challenges for epidemiology [PDF]

The European Journal of Public Health, 2011
While chronic diseases (e.g. obesity, diabetes, coronary heart disease, cancer, etc), also named ‘complex diseases’, are caused by the combined effects of multiple environmental and genetic factors, it is estimated that the environmental component plays a major role. Nevertheless, the smaller role of inherited genetic factors may partly be explained by
Bochud M, Malats N
openaire   +3 more sources