Results 171 to 180 of about 159,690 (243)

Reproductive Isolation due to Divergent Ecological Selection Is Accompanied by Vast Genomic Instability in Experimentally Evolved Yeast Populations. [PDF]

Mol Ecol
Bendixsen DP, Gilchrist C, Haberkorn C, Persson K, Geijer C, Warringer J, Stelkens R.   +6 more
europepmc   +1 more source

H3.1K27M-induced misregulation of the TONSOKU-H3.1 pathway causes genomic instability. [PDF]

Nat Commun
Yuan W, Huang YC, LeBlanc C, Poulet A, De Luna Vitorino FN, Valsakumar D, Dean R, Garcia BA, van Wolfswinkel JC, Voigt P, Jacob Y.   +10 more
europepmc   +1 more source

POLE Deficiency Exacerbates Diesel Engine Exhaust-Induced Genomic Instability and Malignant Transformation of Bronchial Epithelial Cells. [PDF]

Adv Sci (Weinh)
Zhang P, Wu Z, Ju Q, Xu N, Chen X, Chen H, Yang S, Ji J, Zhao Y.   +8 more
europepmc   +1 more source

Distal femoral morphology as a risk factor for osteoarthritis

The Anatomical Record, EarlyView.
Abstract Osteoarthritis (OA) is a leading cause of disability affecting millions of adults in the United States, commonly resulting in the need for total knee arthroplasty (TKA) to restore mobility and quality of life. This study investigates potential differences in baseline distal femoral shape between individuals who received TKA due to OA and a ...
Haley Horbaly
wiley   +1 more source

Interlaced roles of mitochondrial DNA in colorectal cancer: Liquid-biopsy biomarkers, nuclear mtDNA-driven genomic instability, and mito-encoded micro peptide signaling. [PDF]

World J Gastrointest Oncol
Koo TH, Leong XB, Lee YL, Hayati F, Zakaria AD.   +4 more
europepmc   +1 more source

Dysregulation of U12‐Type Splicing in Lupus Neutrophils

Arthritis &Rheumatology, Accepted Article.
Abstract. Objective Neutrophil dysfunction is a hallmark of systemic lupus erythematosus (SLE), but its molecular basis remains unclear. This study explores transcriptional and post‐transcriptional changes in low‐density granulocytes (LDGs), a proinflammatory neutrophil subset expanded in SLE, focusing on NADPH oxidase (Nox) function and minor intron ...
Luz P. Blanco, Binod Regmi, Carmelo Carmona‐Rivera, Yudong Liu, Xiantao Wang, Philip M. Carlucci, Monica M. Jackson, Zerai Manna, Sarfaraz Hasni, Markus Hafner, Hong‐Wei Sun, Mariana J. Kaplan   +11 more
wiley   +1 more source

Calcium hydroxide nanoparticles induce apoptotic cell death in human pancreatic cancer cells through over ROS-driven genomic instability and mitochondrial dysfunction. [PDF]

Sci Rep
Mohamed HRH, Magdy H, Elberry Y, Ismail M, Michael M, Eltayeb N, Safwat G, Diab A.   +7 more
europepmc   +1 more source

Efficacy and safety of empagliflozin for treating neutropenia and neutrophil dysfunction in paediatric patients with glycogen storage disease type Ib: A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims Glycogen storage disease type Ib (GSD‐Ib) is a rare genetic disorder causing neutropenia and neutrophil dysfunction in children. G‐CSF has been the primary treatment, but emerging data support the potential of empagliflozin, an SGLT2 inhibitor, as a promising investigational option.
Elizabeth Iwasyk, Ryan Jin, Fabio Tuzzolino, Giusy Ranucci, Donatella Madonia, Alessio Provenzani   +5 more
wiley   +1 more source

Bioactive glass nanoparticles induce intrinsic p53-dependent apoptosis and promote genomic instability via ROS overproduction and mitochondrial depolarization in triple-negative breast cancer cells. [PDF]

Sci Rep
Mohamed HRH, Borai ME, Mosaad S, Osman AA, Elsewedy AH, Zaki HM, Diab A, Safwat G.   +7 more
europepmc   +1 more source