Results 211 to 220 of about 184,862 (303)

Aging alters genomic instability at endogenous mutation hotspots in mice. [PDF]

Sci Rep
D'Amico AM, Li TT, Wylie D, Wang G, Vasquez KM.   +4 more
europepmc   +1 more source

Long‐Term Ambient Benzene Exposure and Brain Disorders Among Urban Adults: Effect Modification by Genetic Susceptibility and Potential Mediation by Plasma Proteins

Advanced Science, EarlyView.
Low‐level ambient benzene exposure is associated with increased risks of multiple brain disorders in urban adults. Genetic susceptibility modifies these associations, while plasma proteomics points to potential biological pathways linking benzene exposure to adverse brain health.
Jianhui Guo, Xia Zhong, Petros Koutrakis, Carolina L. Zilli Vieira, Feifei Si, Yaqi Wang, Xinyao Lian, Yi Fan, Zhaokun Wang, Shaodan Huang, Jing Li   +10 more
wiley   +1 more source

Metabolic reprogramming-associated genomic instability drives colorectal cancer progression via the UBXN1-NF-κB axis. [PDF]

Am J Transl Res
Qian L, Li Z, Yang T, Xia S, Jin L, Zhu C, Jing W, Wang Y, Ye Y, Shen Y, Li L, Peng H, Yu Q.   +12 more
europepmc   +1 more source

FGF2 causes genomic instability [PDF]

Nature Reviews Urology, 2018
openaire   +2 more sources

A General Enzymatic Strategy for Site‐Specific Incorporation of Modified Genetic Building Blocks Into DNA

Advanced Science, EarlyView.
Eco‐friendly enzymatic synthesis of high‐fidelity, site‐specifically modified DNA using 3′‐blocked nucleotides for full synthetic control and next‐generation sequencing compatibility. ABSTRACT Methods for site‐specific incorporation of modified DNA building blocks remain limited.
Raveena Raveena, Bhavana Ramadas, Sidney Becker   +2 more
wiley   +1 more source

Genomic instability and mono-parental expression mitigate genomic shock in a cross-subgenus <i>Leishmania</i> hybrid. [PDF]

NAR Mol Med
Louzada-Flores VN, Cokelaer T, Fuentes-Carias M, Pescher P, Ferreira TR, Latrofa MS, Mendoza-Roldan JA, Otranto D, Späth GF, Louradour I.   +9 more
europepmc   +1 more source

Molecular Engineering Mediated Interfacial Assembly as an Artificial Extracellular Matrix Remolds Bacteria With Enhanced Abiotic Resilience

Advanced Science, EarlyView.
A biomimetic artificial extracellular matrix is assembled directly on Pseudomonas fluorescens by co‐assembling amyloid‐like lysozyme and alginate at the cell surface. This conformal nanocoating acts as both a hydration buffer and a physiological priming layer, markedly enhancing desiccation tolerance, seed adhesion, storage stability, and biocontrol ...
Yuanyuan Wang, Zili Jia, Yang Li, Qitao Wang, Shuai Hou, Lei Liu   +5 more
wiley   +1 more source

BRCA2 deficiency and replication stress drive APOBEC3-Mediated genomic instability. [PDF]

Nat Commun
Situ K, Duan H, Godin SK, Yang J, McCloskey GQ, Naeem B, Gillis MK, Zeb MH, Salhotra S, Rawal P, Patel N, Mouliere SK, Chen J, Békési A, Pálinkás HL, Venkatesan S, Green AM, Birkbak NJ, Vértessy BG, Swanton C, Pathania S.   +20 more
europepmc   +1 more source

Lessons From Drug Discovery for Cryoprotective Agent Design: An AI‐Oriented Perspective

Advanced Science, EarlyView.
Cryoprotectant design is reframed through the lens of drug discovery as a multiparameter optimization problem. This perspective highlights how AI and systematic design strategies could enable safer, more effective cryoprotectants, while identifying key limitations that currently constrain predictive progress in cryobiology. ABSTRACT Cryopreservation is
Dominika Wilczok, Jesús Valdés‐Hernández, Varinia Bernales, Alán Aspuru‐Guzik, Alex Zhavoronkov   +4 more
wiley   +1 more source

Stratification of telomerase activity in cancer reveals associations with senescence and genomic instability. [PDF]

Comput Struct Biotechnol J
Noureen N, Kang MH.
europepmc   +1 more source