Results 191 to 200 of about 596,095 (346)

Chromatin Organization Governs Transcriptional Response and Plasticity of Cancer Stem Cells

Advanced Science, EarlyView.
Through a combination of transcriptomic and histone mapping studies integrated with chromatin imaging, we define how chromatin organization in nanoscale packing domains fine tunes the plasticity of cancer stem cells (CSCs) driving evasion from and survival after chemotherapy.
Yinu Wang, Jane Frederick, Karla Isabel Medina, Elizabeth Thomas Bartom, Luay Matthew Almassalha, Yaqi Zhang, Greta Wodarcyk, Hao Huang, I Chae Ye, Ruyi Gong, Cody Levi Dunton, Alex Duval, Paola Carrillo Gonzalez, Joshua Pritchard, John Carinato, Iuliia Topchu, Junzui Li, Zhe Ji, Mazhar Adli, Vadim Backman, Daniela Matei   +20 more
wiley   +1 more source

Identification and characterization of 17 microsatellite primers for the tick, Ixodes ricinus, using enriched genomic libraries [PDF]

, 2006
Knut H. Røed, Gunnar Hasle, V. MIDTHJELL, Grethe Skretting, Hans Petter Leinaas   +4 more
openalex   +1 more source

Bioprinted Patient‐Derived Organoid Arrays Capture Intrinsic and Extrinsic Tumor Features for Advanced Personalized Medicine

Advanced Science, EarlyView.
An embedded bioprinting enabled‐arrayed patient‐derived organoids (Eba‐PDO) platform that replicates intrinsic and extrinsic tumor characteristics is introduced. Eba‐PDOs more accurately mimic tissue than standard PDOs (Std‐PDOs) due to maturation in the tumor microenvironment.
Jonghyeuk Han, Hye‐Jin Jeong, Jeonghan Choi, Hyeonseo Kim, Taejoon Kwon, Kyungjae Myung, Kyemyung Park, Jung In Park, Samuel Sánchez, Deok‐Beom Jung, Chang Sik Yu, In Ho Song, Jin‐Hyung Shim, Seung‐Jae Myung, Hyun‐Wook Kang, Tae‐Eun Park   +15 more
wiley   +1 more source

Lock-free de Bruijn graph [PDF]

arXiv
De Bruijn graph is one of the most important data structures used in de-novo genome assembly algorithms, especially for NGS data. There is a growing need for parallel data structures and algorithms due to the increasing number of cores in modern computers.
arxiv  

Advanced resources for plant genomics: a BAC library specific for the short arm of wheat chromosome 1B [PDF]

, 2006
Jaroslav Janda, Jan Šafář, Marie Kubaláková, Jan Bartoš, Pavlína Kovářová, Pavla Suchánková, Stéphanie Pateyron, Jarmila Číhalíková, Pierre Sourdille, Hana Šimková, Patricia Faivre‐Rampant, Eva Hřibová, Michel Bernard, Adam J. Lukaszewski, Jaroslav Doležel, Boulos Chalhoub   +15 more
openalex   +1 more source

Developing Quorum Sensing‐Based Collaborative Dynamic Control System in Halomonas TD01

Advanced Science, EarlyView.
A standardized and streamlined inducer‐free quorum sensing (QS)‐based collaborative dynamic control pattern is developed for sufficient gene expression control in Halomonas TD by mixing two engineered cells, cells A and B. Proof‐of‐concept studies are designed to test the dynamic control performance in mixed cultures in fed‐batch conditions.
Yi‐Na Lin, Yu‐Xi Li, Ye Zheng, Yi‐Hao Deng, Kai‐Xuan Liu, Yue Gan, Hao Li, Jun Wang, Jia‐Wen Peng, Rui‐Zhe Deng, Huai‐Ming Wang, Hui Wang, Jian‐Wen Ye   +12 more
wiley   +1 more source

A novel resource for genomics of Triticeae: BAC library specific for the short arm of rye (Secale cereale L.) chromosome 1R (1RS) [PDF]

, 2008
Hana Šimková, Jan Šafář, Pavla Suchánková, Pavlína Kovářová, Jan Bartoš, Marie Kubaláková, Jaroslav Janda, Jarmila Číhalíková, Rohit Mago, T. Lelley, Jaroslav Doležel   +10 more
openalex   +1 more source

Genome‐Wide Silencer Screening Reveals Key Silencer Modulating Reprogramming Efficiency in Mouse Induced Pluripotent Stem Cells

Advanced Science, EarlyView.
This study utilized Ss‐STARR‐seq to construct a genome‐wide silencer map of mouse cells and elucidated the fundamental characteristics of these silencers. These silencers exist in a cell‐specific manner and exhibit unique epigenetic modifications. Through functional experiments, we also discovered that these silencers can regulate gene expression and ...
Xiusheng Zhu, Lei Huang, Guoli Li, Biao Deng, Xiaoxiao Wang, Hu Yang, Yuanyuan Zhang, Qiuhan Wen, Chao Wang, Jingshu Zhang, Yunxiang Zhao, Kui Li, Yuwen Liu   +12 more
wiley   +1 more source

Construction of Signature-tagged Mutant Library in Mesorhizobium loti as a Powerful Tool for Functional Genomics [PDF]

, 2008
Yoshikazu Shimoda, Hisayuki Mitsui, H. Kamimatsuse, Kiwamu Minamisawa, Eri Nishiyama, Yoshiyuki Ohtsubo, Yuji Nagata, Masataka Tsuda, Sayaka Shinpo, Atsushi Watanabe, M. Kohara, Manabu Yamada, Yasukazu Nakamura, Sho Tabata, Shusei Sato   +14 more
openalex   +1 more source

Transcriptomic Profiling Unveils EDN3+ Meningeal Fibroblasts as Key Players in Sturge‐Weber Syndrome Pathogenesis

Advanced Science, EarlyView.
Sturge‐Weber syndrome (SWS) is characterized by leptomeningeal vascular malformations, leading to seizures and stroke. Analysis of 119 446 brain cells from SWS patients uncovered distinct cell heterogeneity and identified an EDN3⁺ meningeal fibroblast cluster, with WNT5A emerging as a potential key driver of SWS progression and a promising therapeutic ...
Daosheng Ai, Tianyue Ming, Xiaoli Li, Shu Wang, Zhanying Bi, Jinyi Zuo, Zizhang Cheng, Weijin Sun, Mingguo Xie, Fengzhi Li, Xiongfei Wang, Xueling Qi, Guoming Luan, Woo‐ping Ge, Yuguang Guan   +14 more
wiley   +1 more source