Results 241 to 250 of about 596,853 (321)
From Code to Life: The AI‐Driven Revolution in Genome Editing
This review explores AI‐driven advancements in genome editing, focusing on CRISPR optimization, enhanced targeting precision, reduced off‐target effects, and novel tool design. It addresses ethical challenges, data biases, and highlights future prospects in precision medicine, agriculture, and synthetic biology.
Zhidong Li+10 more
wiley +1 more source
DAPCy: a Python package for the discriminant analysis of principal components method for population genetic analyses. [PDF]
Correa Rojo A+4 more
europepmc +1 more source
Library Preparation for Whole Genome Bisulfite Sequencing of Plant Genomes
Carlos M. Rodríguez López+1 more
openaire +4 more sources
Small RNA Toxin‐Assisted Evolution of GC‐Preferred ErCas12a for Enhanced Genome Targeting Range
ErCas12a is engineered to target GC‐rich PAMs using a small RNA toxin‐aided positive screening system. The resulting variant, enErCas12a, exhibits an expanded PAM profile and facilitates efficient gene editing in both bacterial and mammalian cells, while preserving high targeting specificity for both canonical and non‐canonical PAM targets.
Zehua Chen+8 more
wiley +1 more source
Chromosome-level genome assembly and annotation of Pterygoplichthys pardalis. [PDF]
Xia W+10 more
europepmc +1 more source
Using Partial Genomic Fosmid Libraries for Sequencing CompleteOrganellar Genomes
Joel R. McNeal+5 more
openalex +1 more source
Library Construction for Ancient Genomics: Single Strand or Double Strand?
E. Andrew Bennett+5 more
openalex +1 more source
This study elucidates the critical role of Rictor in macrophage activation in acute antibody‐mediated rejection (ABMR). Rictor increases K48‐linked ubiquitination of p65 by upregulating E3 ubiquitin ligase SOCS1, inhibiting transcriptional levels of NLRP3 and inflammasome activation.
Bin Ni+12 more
wiley +1 more source
An improved chromosomal-scale genome assembly of the Tanaka's snailfish (Liparis tanakae). [PDF]
Chen Y, Jin Y, Su C, Zhang F, Shan X.
europepmc +1 more source
This study investigates the role of macrophage pyruvate carboxylase (PC) in atherosclerosis (AS) demonstrating that PC upregulation in macrophages promotes metabolism reprogramming to enhance inflammatory responses via the HIF‐1 signaling pathway.
Ling‐Na Zhao+17 more
wiley +1 more source