Results 251 to 260 of about 596,095 (346)

Genomic Insights into Post‐Domestication Expansion and Selection of Body Size in Ponies

Advanced Science, EarlyView.
The authors’ research delves into the history of ponies by assembling a pony genome and integrating horse genomes. This unveils genetic connections between Asian and European pony breeds. Cis‐regulatory elements of key genes impacting body size are also identified.
Xingzheng Li, Zihao Wang, Min Zhu, Binhu Wang, Shaohua Teng, Jing Yan, Haoyu Wang, Pengxiang Yuan, Shuwei Cao, Xiaolu Qu, Zhen Wang, Kai Zhan, Md. Panir Choudhury, Xintong Yang, Qi Bao, Sang He, Lei Liu, Pengju Zhao, Jicai Jiang, Hai Xiang, Lingzhao Fang, Zhonglin Tang, Yuying Liao, Guoqiang Yi   +23 more
wiley   +1 more source

Multisite clinical cross-validation and variant interpretation of a next generation sequencing panel for lymphoid cancer prognostication. [PDF]

J Clin Pathol
Sabatini PJB, Bridgers J, Huang S, Downs G, Zhang T, Sheen C, Park N, Kridel R, Marra MA, Steidl C, Scott DW, Karsan A.   +11 more
europepmc   +1 more source

Construction of Genomic DNA Library of Korean Ginseng (Panax ginseng C. A. MEYER) and Development of Sequence-Tagged Sites

, 2010
Kyong-Hwan Bang, Jei-Wan Lee, Young‐Chang Kim, Dong‐Hwi Kim, Eung-Ho Lee, Ji‐Ung Jeung   +5 more
openalex   +2 more sources

Citrullination of NF‐κB p65 by PAD2 as a Novel Therapeutic Target for Modulating Macrophage Polarization in Acute Lung Injury

Advanced Science, EarlyView.
Peptidyl arginine deiminase 2 (PAD2) plays a key role in regulating macrophage function in Pseudomonas aeruginosa‐induced acute lung injury (ALI). Using single‐cell RNA sequencing and proteomics, a new PAD2‐catalyzed citrullination site on NF‐κB p65 (171 Arginine), modulating macrophage polarization is identified.
Xin Yu, Yujing Song, Tao Dong, Wenlu Ouyang, Chao Quan, Liujiazi Shao, Leonard Barasa, Paul R. Thompson, Mao Zhang, Jianjie Ma, Katsuo Kurabayashi, Yongqing Li   +11 more
wiley   +1 more source

Complete genome sequence of <i>Microbacterium</i> sp. strain Clip185. [PDF]

Microbiol Resour Announc
Mitra M, Stanescu A.
europepmc   +1 more source

Machine Learning‐Enabled Drug‐Induced Toxicity Prediction

Advanced Science, EarlyView.
Unexpected toxicity accounts for 30% of drug development failures. This review highlights ML innovations in predicting drug‐induced toxicity, emphasizing comparative analyses, interpretable algorithms, and multi‐source data integration. It categorizes toxicity types, summarizes ML models, and organizes key databases, offering strategies to address ...
Changsen Bai, Lianlian Wu, Ruijiang Li, Yang Cao, Song He, Xiaochen Bo   +5 more
wiley   +1 more source

Comprehensive genome-scale CRISPR knockout screening of CHO cells. [PDF]

Sci Data
Shin SW, Kim SH, Gasselin A, Lee GM, Lee JS.   +4 more
europepmc   +1 more source

A toolkit for studyingVarroagenomics and transcriptomics: Preservation, extraction, and sequencing library preparation

, 2020
Nonno Hasegawa, Maéva Angélique Techer, Alexander S. Mikheyev   +2 more
openalex   +1 more source

PPY‐Induced iCAFs Cultivate an Immunosuppressive Microenvironment in Pancreatic Cancer

Advanced Science, EarlyView.
Pancreatic ductal adenocarcinoma features abundant stromal components that hinder therapy efficacy. Single‐cell RNA sequencing analysis combined with experiments identified PPY, a gastrointestinal hormone, as a novel inducer of immunosuppressive iCAFs. Mechanistic studies revealed that PPY activates the non‐canonical NF‐κB pathway via EGFR.
Mengdie Cao, Wang Peng, Bin Cheng, Ronghua Wang, Wei Chen, Luyao Liu, Hai Huang, Shiru Chen, Haochen Cui, JingWen Liang, Qiaodan Zhou, Si Xiong, Shuya Bai, Luoxia Liu, Yuchong Zhao   +14 more
wiley   +1 more source

A pooled CRISPR screen identifies the Tα2 enhancer element as a driver of <i>TRA</i> expression in a subset of mature human T lymphocytes. [PDF]

Front Immunol
Schönberg PY, Muñoz-Ovalle Á, Paszkowski-Rogacz M, Crespo E, Sürün D, Feldmann A, Buchholz F.   +6 more
europepmc   +1 more source