Results 261 to 270 of about 585,279 (315)

Towards a Library of Standard Operating Procedures (SOPs) for (meta)genomic annotation

, 2008
Nikos C. Kyrpides, Samuel V. Angiuoli, Guy Cochrane, Dawn Field, George M Garrity, Aaron Gussman, Chinnappa D. Kodira, William Klimke, Nikos C. Kyrpides, Ramana Madupu, Victor Markowitz, Tatiana Tatusova, Nick Thomson, Owen White   +13 more
openalex   +1 more source

Genomic Insights into the Population Structure and Adaptive Variation of Mullus barbatus in the Mediterranean Sea

Massa P, Leitão HG, Manousaki T, Cariani A, Svardal H, Tsaparis D, Cannas R, Zane L, De Pooter T, Spedicato MT, Strazisar M, Ciofi C, Ferrari A, Diedericks G, Diroma MA, Formenti G, Ivanova P, Cartney AM, Mouton A, Natali C, Marino IA, Tsigenopoulos CS.   +21 more
europepmc   +1 more source

Chromosome-level genome assembly of the Adonis ladybird Hippodamia variegata. [PDF]

Sci Data
Liu HL, Yong YP, Wu XL, Chen ZT, Wei SJ, Cai P, Pu DQ.   +6 more
europepmc   +1 more source

Targeting GPX4 to Induce Ferroptosis Overcomes Chemoresistance Mediated by the PAX8‐AS1/GPX4 Axis in Intrahepatic Cholangiocarcinoma

Advanced Science, EarlyView.
PAX8‐AS1 drives chemoresistance in intrahepatic cholangiocarcinoma by activating NRF2‐mediated GPX4 transcription and stabilizing GPX4 mRNA via IGF2BP3. Targeting the PAX8‐AS1/GPX4 axis with a GPX4 inhibitor enhances the efficacy of gemcitabine and cisplatin in preclinical models, offering a promising strategy to overcome chemotherapy resistance in ...
Zhi‐Wen Chen, Ji‐Jun Shan, Mo Chen, Zong Wu, Yi‐Ming Zhao, Hong‐Xu Zhu, Xin Jin, Yi‐Xiu Wang, Yi‐Bin Wu, Zhen Xiang, Zhi‐Wen Ding, Zhen‐Hai Lin, Long‐Rong Wang, Lu Wang   +13 more
wiley   +1 more source

Genomic Sequencing and Characterization of Two <i>Auricularia</i> Species from the Qinling Region: Insights into Evolutionary Dynamics and Secondary Metabolite Potential. [PDF]

J Fungi (Basel)
Qi J, Kang S, Zhang M, Qi S, Li Y, Vadim K, Du S, Li M.   +7 more
europepmc   +1 more source

Calpain‐2‐Mediated Endothelial Focal Adhesion Disruption in Thoracic Aortic Dissection

Advanced Science, EarlyView.
The elevated expression of Capn2 in endothelial cells activates focal adhesion signaling by cleaving Talin1 and assembling Itgav, which compromises the integrity of the endothelial barrier and induces vascular inflammation. Inhibition of calpain through both pharmacological and transgenic approaches has effectively suppressed the onset and progression ...
Xiaomei Teng, Yansong Wang, Haoyue Huang, Yinglong Ding, Jun Wang, Meili Liu, Kun Song, Lianbo Shao, You Yu, Ziying Yang, Zhenya Shen   +10 more
wiley   +1 more source

A Super‐Enhancer‐Driven Transcriptional Regulatory Circuit Underlying Abiraterone Resistance in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
This study identifies a super‐enhancer‐driven transcriptional regulatory circuit comprising BCL6, SMAD3, and NFIB that cooperate to drive cholesterol synthesis via SREBF2/HMGCR/FDFT1 activation and regulate CDK2/CCND3 for cell cycle control. Targeting this circuit with BI‐3802 or downstream inhibitors (Fatostatin/Lovastatin) overcomes abiraterone ...
Liling Jiang, Jiamin Wang, Guanjie Peng, Haichuan Zhang, Jinxin Fang, Yingyin Gao, Enzhe Lou, Yangzhou Liu, Wa Ding, Bingyuan Liu, Qiong Mao, Lizhen Jiang, Aochu Liu, Xinyue Li, Shiwen Hu, Qiaomin Ma, Yueyuan Zheng, Zhigang Zhao, Xianping Shi   +18 more
wiley   +1 more source

Transposable element accumulation drives genome size increase in Hylesia metabus (Lepidoptera: Saturniidae), an urticating moth species from South America. [PDF]

J Hered
Perrier C, Allio R, Legeai F, Gautier M, Bénéluz F, Marande W, Theron A, Rodde N, Herrera M, Sauné L, Parrinello H, McClure M, Arias M.   +12 more
europepmc   +1 more source

Transient Interdomain Interactions Modulate the Monomeric Structural Ensemble and Self‐Assembly of Huntingtin Exon 1

Advanced Science, EarlyView.
Polyglutamine (polyQ) tract expansion (≥ 36 amino acids) within the N‐terminal region of the Huntingtin protein (Httex1) causes Huntington's disease (HD), for which the underlying causes are not well‐understood. The authors performed computer simulations to understand the cause of HD at the molecular level.
Priyesh Mohanty, Tien Minh Phan, Jeetain Mittal   +2 more
wiley   +1 more source

Draft genome sequence of <i>Streptomyces</i> sp. strain M41 isolated from soil in a conserved region of Sipadan Island, Sabah, Malaysia. [PDF]

Microbiol Resour Announc
Halim MA, Waly NA, Jetony G, Khamis KK, Robinson C, Hussin NA, Ling CMWV, Arshad SE, Amin Z.   +8 more
europepmc   +1 more source