Results 281 to 290 of about 633,728 (345)

A Systemic Selective Modified mRNA Delivery Platform for Preventing Chemotherapy‐Induced Cardiotoxicity

Advanced Science, EarlyView.
In Yoo and Mainkar et al., we present a minimally invasive, CM‐selective modRNA delivery system encapsulated in lipid nanoparticles for intravenous (IV) administration. This platform enables selective cardiac translation of therapeutic modRNA but suppresses expression in off‐target tissues, including tumors.
Jimeen Yoo, Gayatri Mainkar, Matteo Ghiringhelli, Bernardo Gindri Dos Santos, Magdalena M. Żak, Keerat Kaur, Ann Anu Kurian, Matthew Adjmi, Segev Sharon, Eftychia Markopoulou, Lucia Žigová, Daniela Hirsch, Sydney Pessin, Rachel Hanan, Juan Luis Escano Abreu, Niki Brisnovali, Nicole Dubois, Leigh Goedeke, Mengcheng Shen, Lior Zangi   +19 more
wiley   +1 more source

PARPi Combining Nanoparticle LIN28B siRNA for the Management of Malignant Ascites

Advanced Science, EarlyView.
This study demonstrates that co‐inhibition of LIN28B and PARP using siLin28b/DSSP@lip‐PEG‐FA nanoparticles in combination with the PARP inhibitor BMN673 effectively suppresses the accumulation of malignant ascites associated with advanced cancers.
Yan Fang, Qian Shen, Yao Lin, Jing Zhu, Xiaolan Zhu, Rui Huang, Yijia Wu, Feiyang Shen, Qian Li, Guopei Zheng, Zhe Zhang, Qian Chu, Junhao Hu, Jianfeng Shen   +13 more
wiley   +1 more source

Chromosome-level genome assembly of Schizodactylus jimo He, 2021 from China (Ensifera: Schizodactylidae). [PDF]

Sci Data
Yao B, Jiang T, Yang L, Wang J, Guan D, Xu SQ.   +5 more
europepmc   +1 more source

p16Ink4a‐Positive Hepatocytes Drive Liver Fibrosis Through Activation of LIFR Family Pathway

Advanced Science, EarlyView.
This study found that, following the long‐term CCl4 treatment, p16high hepatocytes appeared in zone 3, spatially co‐localizing with fibrotic areas. A specific cluster of p16high hepatocytes upregulated CTF1/LIF expression which induced HSC activation and further liver fibrosis, as revealed by single cell transcriptomic analysis.
Koji Nishikawa, Teh‐Wei Wang, Satoshi Kawakami, Shota Tanimoto, Kiyoshi Yamaguchi, Taketomo Kido, Masamichi Kimura, Tsunekazu Hishima, Yuki T. Okamura, Satotaka Omori, Takumi Iritani, Toshikaze Chiba, Takehiro Jimbo, Michio Katano, Kansuporn Kamataki, Ryoichi Yokoyama, Eigo Shimizu, Kiminori Kimura, Satoshi Yamzaki, Seiya Imoto, Yoichi Furukawa, Atsushi Miyajima, Yoshikazu Johmura, Makoto Nakanishi   +23 more
wiley   +1 more source

Comprehensive evaluation of diverse massively parallel reporter assays to functionally characterize human enhancers genome-wide. [PDF]

Genome Biol
Zhang J, Leung AK, Zhu Y, Yao L, Willis A, Pan X, Ozer A, Zhou Z, Siklenka K, Barrera A, Liang J, Tippens ND, Reddy TE, Lis JT, Yu H.   +14 more
europepmc   +1 more source

CD168 Identifies Proliferating Pancreatic Islet Cells in Murine and Human

Advanced Science, EarlyView.
This study identifies CD168 as a conserved surface marker for proliferating β‐cells in mouse, human islets, and pancreatic islet tumors. CD168⁺ cells show high proliferation and low insulin expression. CD168+ cells form mostly uni‐β lineage clones, and some of the clones are multi‐lineage.
Shubo Yuan, Jiafu Li, Min Shao, Haili Bao, Ajun Geng, Jialin Yang, Yu Tao, Xinyi Chen, Tianxiong Xiao, Chunye Liu, Zhiyao Xie, Wenqian Song, Qing Cissy Yu, Hongxing Fu, Xu Han, Taochen He, Wenquan Wang, Jianfeng Chen, Sheng Yan, Shaohua Song, Liang Liu, Yi Arial Zeng   +21 more
wiley   +1 more source

Chromosome-level genome assembly and annotation of the Triplophysa pappenheimi. [PDF]

Sci Data
Li Y, Liu D, Yao Z, Gao Q, Zhang C, Wang W, Jia J, Liu S, Tian F, Qi D.   +9 more
europepmc   +1 more source

Draft genome sequence of <i>Nocardioides</i> strain MAHUQ-72 isolated from soil sample of a rice field located in Anseong, South Korea. [PDF]

Microbiol Resour Announc
Huq MA, Akter S, Islam MS, Rahman MS.
europepmc   +1 more source

A chromosome-level genome assembly of Verticillium albo-atrum, an dangerous quarantine pathogen known for causing verticillium wilt. [PDF]

BMC Genom Data
Chen Y, Chen Y, Deng Y, Mao Z, Li Y, Zhao J, Chen G, Ling J.   +7 more
europepmc   +1 more source

Library of the Center for Law and Bioethics in the Field of Genomic Research and Application of Genetic Technologies of Kutafin Moscow State Law University (MSAL)

Article Editorial
openalex   +2 more sources