Results 281 to 290 of about 596,095 (346)

A reference library for the identification of Canadian invertebrates: 1.5 million DNA barcodes, voucher specimens, and genomic samples

open access: gold, 2019
Jeremy D. deWaard   +31 more
openalex   +2 more sources

Dimethyl Itaconate Alleviates Escherichia coli‐Induced Endometritis Through the Guanosine‐CXCL14 Axis via Increasing the Abundance of norank_f_Muribaculaceae

open access: yesAdvanced Science, EarlyView.
The research findings indicate that dimethyl itaconate (DI) alleviates Escherichia coli (E. coli) induced endometritis by modulating the gut microbiota and enriching the abundance of norank_f_Muribaculaceae, thereby increasing the production of guanosine.
Yuhang He   +6 more
wiley   +1 more source

Comprehensive genomic dependency landscape of a human colon cancer organoid. [PDF]

open access: yesCommun Biol
Khalili S   +12 more
europepmc   +1 more source

DNA–Protein Binding is Dominated by Short Anchoring Elements

open access: yesAdvanced Science, EarlyView.
This study delineate the binding mechanism of transcription factors (TFs) in the genome with the knowledge obtained at thermodynamic equilibrium conditions. Through KaScape experiments, combined with the AEEscape algorithm development, they identified the minimal dominant interacting elements, termed as Anchoring Elements (AEs).
Hong Chen   +3 more
wiley   +1 more source

Inhibiting the Histone Demethylase Kdm4a Restrains Cardiac Fibrosis After Myocardial Infarction by Promoting Autophagy in Premature Senescent Fibroblasts

open access: yesAdvanced Science, EarlyView.
Kdm4a downregulation restrains excessive cardiac interstitial fibrosis and remodeling by depressing the premature senescence of fibroblasts in the advanced stage after MI but does not affect early ventricular rupture. It verified that Kdm4a downregulation promotes autophagy in premature senescent fibroblasts by increasing the H3K9m3 modification of the
Ming Jin   +15 more
wiley   +1 more source

Antagonist Targeting the Species‐Specific Fatty Acid Dehydrogenase/Isomerase FabX for Anti‐H. pylori Infection

open access: yesAdvanced Science, EarlyView.
This study demonstrates that the atypical dehydrogenase/isomerase FabX in Type‐II fatty acid biosynthesis pathway is essential for H. pylori infection by retaining unsaturated fatty acid synthesis and producing superoxide (ROS). A small molecule FBX‐1991 that specifically targets FabX to inhibit H.
Lin Zhang   +9 more
wiley   +1 more source

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