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Predicting structures for genome proteins
Current Opinion in Structural Biology, 1999Assigning three-dimensional protein folds to genome sequences is essential to understanding protein function. Although experimental three-dimensional structures are currently available for only a very small fraction of these sequences, computational fold assignment is able to assign folds to 20-30% of the sequences in various genomes.
D, Fischer, D, Eisenberg
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Exon prediction in eucaryotic genomes
Biochimie, 1996Two independent computer systems, NetPlantGene and AMELIE, dedicated to the identification of splice sites in plant and human genomes, respectively, are introduced here. Both methods were designed in relation to experimental work; they rely on automatically generated rules involving the nucleotide content of sequences regardless of the coding ...
Vignal, L. +6 more
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Predicting disease using genomics
Nature, 2004Information from the human genome sequence will eventually alter many aspects of clinical practice. It will increase through our understanding of disease mechanisms, and guide the development of new drugs and therapeutic procedures. In the short term, however, knowledge of the genome will have a profound clinical impact on the diagnostic capability of ...
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Genomic selection: genome-wide prediction in plant improvement
Trends in Plant Science, 2014Association analysis is used to measure relations between markers and quantitative trait loci (QTL). Their estimation ignores genes with small effects that trigger underpinning quantitative traits. By contrast, genome-wide selection estimates marker effects across the whole genome on the target population based on a prediction model developed in the ...
Zeratsion Abera, Desta, Rodomiro, Ortiz
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Prediction of Genomic Functional Elements
Annual Review of Genomics and Human Genetics, 2006As the number of sequenced genomes increases, the ability to deduce genome function becomes increasingly salient. For many genome sequences, the only annotation that will be available for the foreseeable future will be based on computational predictions and comparisons with functional elements in related species.
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Nature, 2013
Microbial cells make up the majority of cells in the human body, and most of these reside in the intestinal tract. Researchers have long recognized that some intestinal microorganisms are associated with health, but the beneficial impact of most of the gut's microbes on human metabolism has been discovered only relatively ...
de Vos, W.M., Nieuwdorp, M.
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Microbial cells make up the majority of cells in the human body, and most of these reside in the intestinal tract. Researchers have long recognized that some intestinal microorganisms are associated with health, but the beneficial impact of most of the gut's microbes on human metabolism has been discovered only relatively ...
de Vos, W.M., Nieuwdorp, M.
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Genome-Wide Association Studies and Genomic Prediction
20131. R for Genome-Wide Association Studies Cedric Gondro, Laercio R. Porto-Neto, and Seung Hwan Lee 2. Descriptive Statistics of Data: Understanding the Data Set and Phenotypes of Interest Sonja Dominik 3. Designing a Genome-Wide Association Studies (GWAS): Power, Sample Size, and Data Structure Roderick D. Ball 4.
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2015
Genomic prediction uses markers (SNPs) across the whole genome to predict individual breeding values at an early growth stage potentially before large scale phenotyping. One of the applications of genomic prediction in plant breeding is to identify the best individual candidate lines to contribute to next generation.
Edriss, Vahid +5 more
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Genomic prediction uses markers (SNPs) across the whole genome to predict individual breeding values at an early growth stage potentially before large scale phenotyping. One of the applications of genomic prediction in plant breeding is to identify the best individual candidate lines to contribute to next generation.
Edriss, Vahid +5 more
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Genome update: prediction of membrane proteins in prokaryotic genomes
Microbiology, 2005Jannick D, Bendtsen +3 more
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