Results 101 to 110 of about 177,494 (251)
Fast computation of the eigensystem of genomic similarity matrices
BMC BioinformaticsThe computation of a similarity measure for genomic data is a standard tool in computational genetics. The principal components of such matrices are routinely used to correct for biases due to confounding by population stratification, for instance in ...Georg Hahn, Sharon M. Lutz, Julian Hecker, Dmitry Prokopenko, Michael H. Cho, Edwin K. Silverman, Scott T. Weiss, Christoph Lange +7 moredoaj +1 more sourceNatural Biomaterials for Osteochondral Repair: From Source to Strategy
Advanced Healthcare Materials, EarlyView.Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.Hengyu Liu, Hanyang Zhang, Wenbo Yang, Hao Chen, Jincheng Wang, Fei Chang +5 morewiley +1 more sourceJoint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder [PDF]
, 2015 Genetic risk prediction has several potential applications in medical research and clinical practice and could be used, for example, to stratify a heterogeneous population of patients by their predicted genetic risk.Caesar, Sian, Strohmaier, Jana, Wray, Naomi R., Wiersma D., Puri, Vinay, McGough J. J., Collier, David A., Myin-Germeys, Inez, Absher D., Chen, G. B., Loo, Sandra K., Wijsman E. M., Hallmayer, Joachim, Berrettini, Wade, Paterson A. D., Black D. W., Lathrop, Mark, Leboyer, Marion, Craddock, Nicholas, Lee, S Hong; id_orcid, Maier, R., Pato, Carlos N., Coryell W. H., Franke B., Datta S., Smalley, Susan L., Hansen, Thomas F., Zhang, Peng, Parr JR, Moser G., Santangelo S. L., Pericak-Vance M. A., Mühleisen, Thomas W., Van Os, Jim, Holmans, Peter Alan, Madden P. A. F., Hakonarson, Hakon, Nyholt, Dale R., Krabbendam, Lydia, Moser, Gerhard, State, Matthew, Landen M, De Geus E. J., Roeyers H., Freedman, Robert, Kent, Lindsey, Klauck S. M., Mahon, Pamela B., Gross, Magdalena, Freedman R., Duketis E., Sanders S. J., Nievergelt, Caroline M., Caesar S., Rouleau, Guy, Moreno-De-Luca, Daniel, Elia J., Farmer, Anne E., Hamilton, Steven P., Lesch K. -P., Lawrence J., Hipolito, Maria, Raychaudhuri, Soumya, Vicente, Astrid M., Schalling, Martin, Thapar, Anita, Kwan P., Lee, Sang Hong, Blackwood D. H. R., Craig D. W., Etain, Bruno, Boomsma, Dorret I., Kendler K. S., De Geus, Eco J., et al., Foroud, Tatiana, Gejman, Pablo V., Hickie I. B., Raychaudhuri S., Kennedy, James L., McQuillin, Andrew, Rossin L., Thirumalai S., Van Grootheest G., Ripke, Stephan, Pato, Michele T., Landén, Mikael, Ruderfer, Douglas, Lohoff F. W., Green E. K., Propping P., Maier R, Oliveira G., Kuntsi, Jonna, Li, Jun, Grice D. E., Kahler A. K., van den Oord, Edwin J.C.G., Kendler, Kenneth, other, and, Ribases M., McIntosh, Andrew; id_orcid, Shilling, Paul D., Lord C., Klauck, Sabine M., Kuntsi J., Rasmussen H. B., Vincent J. B., Faraone S. V., Levinson DF, Xu, Wei, Kohli M. A., Banaschewski, Tobias, Agartz I., Gross M., Frank, Josef, Hakonarson H., Tozzi, Federica, Myers R. M., Farmer, Anne, Morrow, Eric M., Wray N. R., Penninx B. W., Gershon E. S., Hong Lee, S., Weissman, Myrna M, Schachar R., Farmer A. E., Levinson, D. F., Doyle, Alysa E., Pato M. T., Santangelo, Susan L., Schellenberg G. D., Leboyer M., Georgieva, Lyudmila, Geschwind D. H., Lewis, Catrin, Coryell, W.H., Middeldorp C. M., Ingason A., Willemsen G., Kuntsi, Jonna; id_orcid, Willsey, A. Jeremy, Watson S. J., Sutcliffe, James, Etain B., Szatmari, Peter, Schwarz, Markus, Smith, Erin N., Psychiatric Genomics Consortium, Cross-Disorder Working Group of the, Hamilton S. P., O'Donovan, Michael Conlon, Medeiros H., Cantor R. M., Amin, Farooq, Visscher, Peter M., Cantor, Rita M., Kenny, Elaine, Hottenga, J.J., Cormand B., Linszen D. H., Smalley S. L., Tzeng J. -Y., McGhee, Kevin A., Vincent, John B., Daly, Mark J., Tzeng, Jung-Ying, Scott L. J., Gill M., Kahn, René S., Middeldorp, C.M., Potash, James B, Stroup, T. Scott, Coryell, William, Hautzinger, Martin, Breen, Gerome, Pickard, Benjamin S., Yu T. W., Olsen, Line, Nurnberger J. I., Vieland V. J., Giegling, Ina, Zandi, Peter P., Smith E. N., Quinn E. M., Tozzi F., Sonuga-Barke, E, Chambert K., Bayés, Mònica, Sullivan P. F., Choudhury, Khalid, McKinney, Rebecca, Medeiros, Helena, Rice, John P., Mowry B. J., Parr J. R., Lewis, Cathryn; id_orcid, Bauer, Michael, Martin, Nicholas G., Hultman, Christina M., Sonuga-Barke, Edmund; id_orcid, Landén, M., Cormican P., Smit J. H., Ingason, Andrés, Kim, Yunjung, Malhotra A. K., Roeder, Kathryn, Betancur C., Nwulia E. A., Shi, J., Cook, Edwin H., Rietschel, Marcella, Wienker T. F., Lande´n, Mikael, Shyn, Stanley I., van den Oord E. J. C. G., Zitman F. G., Van Grootheest, Gerard, Levinson D. F., McGuffin P., Binder E. B., Bayes M., Gill, Michael, Corvin, Aiden, McIntosh A., Owen, Michael J., Young A. H., State M., Akil H., Konte B., Duan, Jubao, Konte, Bettina, Moran J. L., Shi, J. X., Craddock N., Flickinger, Matthew, Nimgaonkar V., McKinney R., Gurling, Hugh, Hoefels, Susanne, Middleton, Lefkos, Schwarz M., Medland, Sarah E., Dawson G., Scott, Laura J., Lieberman J. A., Edenberg, Howard J., Edenberg H. J., Asherson, Philip, Nicol Ferrier I, Mattheisen, Manuel, Buccola N. G., Klei, Lambertus, Andreassen, Ole A., Nikolov I., Malhotra, Anil K., Pericak-Vance, Margaret A., Guan W., Purcell S. M., Nimgaonkar, Vishwajit, Young, Allan H., Kendler KS, Lichtenstein, Paul, Matthews K., Schalling M., Kendler, K. S., Coon H., Kohli, Martin A., Doyle A. E., Maier, Wolfgang, Langstrom N., Montgomery G. W., Franke, B., Backlund L., Smit, Johannes H., Breen G., MacIntyre D. J., Hultman CM, Palotie, Aarno, Hickie, Ian B., Kelsoe J. R., Nievergelt C. M., Heath A. C., Moskvina V., Kenny E., Lin, Dan-Yu, Collier D. A., Backlund, Lena, Shyn S. I., Quested D. J., Weissman, M.M., McCarroll S. A., Lucae S., Buccola, Nancy G., Levinson, Douglas, Holsboer F., Moreno-De-Luca D., Milanova V., Gordon, Scott D., Miranda, Ana, O’Donovan, Michael C., Wray, Naomi, Lencz T., Boehnke, Michael, Meyer, Jobst, Gordon-Smith, Katherine, Reif, Andreas, Kent L., Badner J. A., Lathrop M., Chen, G.B., Smoller, J. W., Amin F., Li J., Landen M., Coryell, W., Binder, Elisabeth B., Hartmann, Annette M., Hipolito M., Murtha M., Robert Cloninger C., Chen G-B, Lencz, Todd, Czamara, Darina, Frisén, Louise, McGrath P. J., Lichtenstein P., Middleton L., Nelson, Stan F., Green, Elaine K., St Clair D., Perlis, Roy H., Scherer S. W., Sanders A. R., Jones, Leslie, de Geus, E.J.C., Grice, Dorothy E., Willemsen, G.; id_orcid, Anjorin, Adebayo, Bettecken, Thomas, Keller, Matthew C., Morken G., Cook E. H., Gallagher L., Ennis S., Treutlein, Jens, Battaglia A., Schumacher J., Weissman MM, Hultman, Christina, Hoogendijk W. J., Cross-Disorder Working Group, of the Psychiatric Genomics Consortium, Myin-Germeys I., Anjorin A., Morrow E. M., Nolen W. A., Kwan, Phoenix, Neale, Benjamin M., Haines, Jonathan L., Grozeva, Detelina, Holmans P. A., Coryell, William H., Ebstein R. P., Freitag C. M., Cormican, Paul, Daly M. J., Cross-Disorder Working Group of the Psychiatric Genomics Consort,, Neale B. M., Frank J., McMahon W. M., McIntosh, Andrew, Kandaswamy, Radhika, Purcell, Shaun M., Friedl M., Buitelaar, J.K., Jones, Lisa, Bergen, Sarah E., Liu, Chunyu, Anney R., Steinhausen H. -C., Bass, Nicholas, Piven J., Fraser C., Chakravarti, Aravinda, Gershon, Elliot S., Rujescu, Dan, Rouleau G., Badner, Judith A., Foroud T., Frisen L., Schatzberg A. F., Bellivier F., Ramos-Quiroga, Josep Antoni, Strauss, John S., Scolnick E., Freimer N. B., Kahn R. S., Xu W., Shilling P. D., Hultman, C. M., Kirov, George K., Zollner S., Cuccaro M. L., Hottenga, Jouke-Jan, Thapar A., Lin D. -Y., Barchas J. D., Posthuma D., Williams, Nigel, Potash J. B., Lewis, Cathryn M., Osby, Urban, Cloninger, C. Robert, Wassink, Thomas H., Lee, S Hong, Jones I., Arking D. E., Fraser, Christine, Banaschewski T., Gurling H., Uhr M., Coryell W., Owen M. J., Dudbridge, Frank, Holmans, Peter A., Nurnberger, John I., Boehnke M., Lee, S. H., Scolnick, Edward, Breen, Gerome; id_orcid, Potash, James, Nöthen, Markus M., Holsboer, Florian, Nyholt, Dale, Klei L., Craig, David W., Van Os J., Henders, Anjali K., Puri V., Maier W., Zandi P. P., Maier, Robert, Scheftner, William A, Långström, Niklas, Datta, Susmita, Melle I., Herms, Stefan, Potash, James B., Wray, Naomi R, Scheftner, William, Propping, Peter, Boomsma D. I., Krasucki R., Krabbendam L., Ebstein, Richard P., Muglia P., McMahon, Francis J., Sklar, Pamela, Ledbetter, David H., Lowe, Jennifer K., Donohoe G. J., Middeldorp, Christel M., Ising M., Schork, Nicholas J., McGhee K. A., Kelsoe, John R., Hottenga J. -J., Young AH, Hoefels S., Azevedo M. H., Hallmayer J., Scheftner, W. A., Schulze T. G., Kendler, Kenneth S, Steinhausen, Hans-Christoph, Biederman, Joseph, Bergen S. E., Rujescu D., Jones L., Scheftner W. A., Hansen T. F., Mahon P. B., Silverman J. M., Ising, Marcus, Medland S. E., Cross-Disorder Working Group of the Psychiatric Genomics Consortium (incl Kent L), Fanous A., Magnusson, Patrik K.E., McMahon F. J., Andreassen O. A., Pimm J., Werge, Thomas, Kähler, Anna K., Weissman, Myrna M., Walsh, Christopher A., Kirov G. K., Shi, Jianxin, Barchas, Jack D., Szelinger, Szabocls, Roeder K., Bellivier, Frank, Olincy, Ann, Visscher P. M., Hultman, C.M., Jamain, Stéphane, Werge T., Georgieva L., Moran, Jennifer L., ?, ?, McMahon, William M., Thompson, Robert C., Maier R., Buxbaum, Joseph D., Guan, Weihua, Barrett, Thomas B., Moser, G., Zhang P., Smoller, J.W., Black, Donald W., Craig I. W., Ripke S, Milanova, Vihra, Landén, Mikael,, Ripke S., Day R., Rehnström, Karola, Day, Richard, Martin C. L., Cichon, Sven, Ribasés, Marta, Coryell W, Lord, Catherine, Wray, N.R., Zammit S., Kirov, George, Nikolov, Ivan, Penninx, Brenda W., Schulze, Thomas G., Todorov, Alexandre A., Cuccaro, Michael L., Keller M. C., Sanders, Alan R., Bass N., Sullivan, Patrick F., Moskvina, Valentina, Oades, Robert D., St Clair, David, Freimer, Nelson B., Bunney, William E., Lee P. H., Byerley, William F., Moser G, Arking, Dan E., Mane, Shrikant M., Weiss L. A., O'Dushlaine C., Lee, Phil H., Smoller J. W., Rice J. P., Absher, Devin, Choudhury K., Craig, Ian, Cross-Disorder Working Group of the Psychiatric Genomics Consortium, Scheftner WA, Chen G. -B., Pimm, Jonathan, Smoller, Jordan, Linszen, Don H., Wienker, Thomas F., Koller, Daniel L., Müller-Myhsok, Bertram, Scheftner, W.A., Ferrier, I. Nicol, Loo S. K., Liu C., Slager, Susan L., Byerley W. F., Maestrini E., Ennis, Sean, Paterson, Andrew D., Breuer R., Lee, S. Hong, Lucae, Susanne, Jamain S., Craig, Ian W., Young, Allan; id_orcid, Korszun, Ania, Casas M., Pergadia, Michele L., Koller D. L., Muglia, Pierandrea, Thirumalai, Srinivasa, Giegling I., McQuillin A., Maestrini, Elena, Flickinger M., Corvin A., Schellenberg, Gerard D., Cichon S., Donohoe, Gary J., Rasmussen, Henrik B., Steffens, Michael, Witt, Stephanie H., Djurovic S., Posthuma, Danielle, Wijsman, Ellen M., Hus V., Martin N. G., Meyer J., Slager S. L., Kendler, Kenneth S., Lesch, Klaus-Peter, Potash, J.B., Asherson P., Dawson, Geraldine, Mattheisen M., Hamshere M. L., Ledbetter D. H., Hultman, Christina M, Cormand, Bru, Duan J., Weissman, M. M., Monaco, Anthony P., Zöllner, Sebastian, Djurovic, Srdjan, Coon, Hilary, Lawrence, Jacob, McLean, Alan W., Barnes M. R., Yu, Timothy W., Sonuga-Barke, Edmund J.S., Williams N., Ripke, S, Silverman, Jeremy M., Franke, Barbara, Jones, Ian Richard, Ophoff, Roel A., Azevedo, Maria H., Chen, G., Pato C. N., Cahn W., Jeremy Willsey A., Todorov A. A., Buitelaar J. K., Schumacher, Johannes, Ophoff R. A., Scott Stroup T., Buitelaar, Jan K., Potash JB, Uhr, Manfred, Meier S., Meier, Sandra, Korszun A., Breuer, René, Bloss, Cinnamon S., Montgomery, Grant W., Smoller, Jordan W., Anney, Richard, Weissman, Myrna, Murtha, Michael, De Haan, Lieuwe, Gordon-Smith K., Quinn, Emma M., Nelson S. F., Hoogendijk, Witte J., Degenhardt, Franziska, Lowe J. K., Rothenberger A., Quested, Digby J., Barrett T. B., Oades R. D., Devlin B., Szatmari P., Asherson, Philip; id_orcid, Nolen, Willem A., Knowles, James A., Grozeva D., Vieland, Veronica J., Thompson R. C., Gejman P. V., De Haan L., Vicente A. M., Perlis R. H., Knowles J. A., Freitag, Christine M., Hautzinger M., Nyholt D. R., Bruggeman, Richard, Ramos-Quiroga J. A., McInnis M. G., Chakravarti A., Meng F., Faraone, Stephen V., Martin, Christa L., Szelinger S., Lee SH, Fombonne E., Palotie A., Degenhardt F., Lawson, William B., Mowry, Bryan J., Devlin, Bernie, Levinson, D.F., Kendler, K.S., Olsen L., Sanders, Stephan J., Miranda A., Scheftner, William A., Potash, J. B., Sutcliffe J., Sergeant, Joseph A., Elia, Josephine, Krasucki, Robert, Morris, Derek W., MacIntyre, Donald J., Witt S. H., Scherer, Stephen W., Hus, Vanessa, Magnusson P. K. E., Duketis, Eftichia, Hamshere, Marian L., Piven, Joseph, Willemsen, Gonneke, Mattingsdal, Morten, Sonuga-Barke E. J. S., Bruggeman R., Nicol Ferrier I., Olincy A., de Geus, E.J.C.; id_orcid, Wiersma, Durk, Wray NR, Morris D. W., Wassink T. H., Madden, Pamela A.F., Hultman C. M., Curtis, David, Rietschel M., Czamara D., Schachar, Russell, Watson, Stanley J., Greenwood T. A., Treutlein J., Cahn, Wiepke, Lohoff, Falk W., Chambert, Kimberly, Biederman J., Hartmann A. M., Melle, Ingrid, Myers, Richard M., Chen, Guo-Bo, Boomsma, D.I.; id_orcid, Rossin, Lizzy, O'Donovan M. C., Poustka F., Crosbie J., Curtis D., Greenwood, Tiffany A., Bailey, Anthony J., Henders A. K., Zammit, Stanley, Friedl, Marion, O’Dushlaine, Colm, Owen, Michael John, Zitman, Frans G., Bloss C. S., Lewis C. M., Buxbaum J. D., Bauer M., Casas, Miguel, McGrath, Patrick J., Bailey A. J., Pergadia M. L., Morken, Gunnar, Levinson, Douglas F, Lee, S.H., Betancur, Catalina, Walsh C. A., Weissman M. M., Steffens M., Mane S. M., Muller-Myhsok B., Nothen M. M., Monaco A. P., Fombonne, Eric, Roeyers, Herbert, Agartz, Ingrid, Rehnstrom K., Weiss, Lauren A., Bettecken T., Strohmaier J., Schatzberg, Alan F., Reif A., Ripke, S., Rothenberger, Aribert, Schork N. J., Shi J, Poustka, Fritz, Wray, N. R., Lee S. H., Gallagher, Louise, Smoller JW, Weissmann, M.M., Kandaswamy R., Levinson, Douglas F., Gordon S. D., Parr, Jeremy R., Lieberman, Jeffrey A., Willemsen, G., Kennedy J. L., Cross-Disorder Working Group of the Psychiatric Genomics, Consortium., Sklar P., Barnes, Michael R., Boomsma, D.I., Lawson W. B., Meng, Fan, Smoller, Jordan W, Osby U., Akil, Huda, McGough, James J., Shi J., Jones, Ian, Muhleisen T. W., Matthews, Keith, Strauss J. S., Haines J. L., Mattingsdal M., Geschwind, Daniel H., Herms S., Sergeant J. A., Oliveira, Guiomar, Nwulia, Evaristus A., Ruderfer D., Battaglia, Agatino, McInnis, Melvin G., Berrettini W., Dudbridge F., Pickard B. S., McGuffin, Peter, McCarroll, Steven A., Bunney W. E., Kim Y., McLean A. W., Crosbie, Jennifer, Heath, Andrew C., Blackwood, Douglas H.R., Fanous, Ayman +846 morecore +1 more sourceA Dual‐Bioresponsive and Programmable Microneedle Matrix as a Bioinspired Coupler for Orchestrating Diabetic Bone Regeneration
Advanced Materials, EarlyView.This project developed a smart bandage‐like patch (a microneedle array) for repairing diabetic bone damage. It intelligently senses signals from infection and inflammation, then releases its medicines in a specific, timed sequence: first an antibacterial agent, then an anti‐inflammatory agent, and finally growth factors.Yu Wang, Rui Chen, Yu Chen, Haowen Lu, Yuchen Qian, Zhiheng Gao, Zheming Shen, Xiaofei Zheng, Huilin Yang, Jun Zou, Yusen Qiao +10 morewiley +1 more sourceChromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities
Advanced Science, EarlyView.ABSTRACT
Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar +3 morewiley +1 more sourceMesenchymal Stromal Cell‐Mediated Intercellular Communication: Mapping the Interactome for Skeletal Muscle Homeostasis and Regeneration
Advanced Science, EarlyView.Liu et al. define a systems‐level interactome of fibroadipogenic progenitor (FAP)‐mediated signaling in skeletal muscle by integrating single‐cell transcriptomics with FAP depletion‐based perturbation analysis. Functional interrogation using a conditioned media bioassay links predicted signaling to multicellular outcomes, establishing a framework to ...Xingyu Liu, Edgar E. Perez Carbajal, Yih‐Chii Hwang, Sahil A. Mapkar, Benjamin W. Gilman, Sarah A. Bliss, Lam B. Tran, Kalgi T. Mehta, Jacob O. Banyasz, Ming Yu, Reynold R. Liu, Matthew N. Ly, Christapher S. Morrissey, Michael N. Wosczyna +13 morewiley +1 more sourceERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells
Advanced Science, EarlyView.With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...Xiaolei Zhao, Shannon Erhardt, Li Tang, Xiaotong Chen, Stephen M Farmer, Zixiu Cheng, Wen Chen, Ella Ziyuan Lu, Kihan Sung, Chang‐Ru Tsai, Mingjie Zheng, Sheng Zhang, Yang Liu, Jianxin Wang, Min Li, James F Martin, Jun Wang +16 morewiley +1 more sourceGATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction
Advanced Science, EarlyView.This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang +16 morewiley +1 more source
