Results 51 to 60 of about 177,494 (251)

Estimating quantitative genetic parameters in wild populations:A comparison of pedigree and genomic approaches [PDF]

, 2014
The estimation of quantitative genetic parameters in wild populations is generally limited by the accuracy and completeness of the available pedigree information. Using relatedness at genome-wide markers can potentially remove this limitation and lead to
Pemberton, Josephine M, Ellis, Philip A., Pemberton, Josephine M., Bérénos, Camillo, Ellis, Philip A, Pilkington, Jill G., Pilkington, Jill G   +6 more
core   +1 more source

Invited review: Unknown-parent groups and metafounders in single-step genomic BLUP

Journal of Dairy Science, 2022
: Single-step genomic BLUP (ssGBLUP) is a method for genomic prediction that integrates matrices of pedigree (A) and genomic (G) relationships into a single unified additive relationship matrix whose inverse is incorporated into a set of mixed model ...
Yutaka Masuda, Paul M. VanRaden, Shogo Tsuruta, Daniela A.L. Lourenco, Ignacy Misztal   +4 more
doaj   +1 more source

A Random Regression Model Based on a Single-Step Method for Improving the Genomic Prediction Accuracy of Residual Feed Intake in Pigs

Frontiers in Genetics, 2022
Residual feed intake (RFI) is considered as a measurement of feed efficiency, which is greatly related to the growth performance in pigs. Daily feeding records can be obtained from automatic feeders.
Ye Wang, Ye Wang, Chenguang Diao, Chenguang Diao, Huimin Kang, Wenjie Hao, Raphael Mrode, Junhai Chen, Jianfeng Liu, Jianfeng Liu, Lei Zhou, Lei Zhou   +11 more
doaj   +1 more source

Optimized Use of Low-Depth Genotyping-by-Sequencing for Genomic Prediction Among Multi-Parental Family Pools and Single Plants in Perennial Ryegrass (Lolium perenne L.)

Frontiers in Plant Science, 2018
Ryegrass single plants, bi-parental family pools, and multi-parental family pools are often genotyped, based on allele-frequencies using genotyping-by-sequencing (GBS) assays. GBS assays can be performed at low-coverage depth to reduce costs.
Fabio Cericola, Ingo Lenk, Dario Fè, Stephen Byrne, Stephen Byrne, Christian S. Jensen, Morten G. Pedersen, Torben Asp, Just Jensen, Luc Janss   +9 more
doaj   +1 more source

The effect of genomic information on optimal contribution selection in livestock breeding programs

, 2013
Long-term benefits in animal breeding programs require that increases in genetic merit be balanced with the need to maintain diversity (lost due to inbreeding). This can be achieved by using optimal contribution selection.
Hickey, John M, Clark, Samuel A, John M Hickey, Brian P Kinghorn, van der Werf, Julius Hj, Samuel A Clark, Julius HJ van der Werf, Kinghorn, Brian P   +7 more
core   +1 more source

Different genomic relationship matrices for single-step analysis using phenotypic, pedigree and genomic information

Genetics Selection Evolution, 2011
Background The incorporation of genomic coefficients into the numerator relationship matrix allows estimation of breeding values using all phenotypic, pedigree and genomic information simultaneously.
Aguilar Ignacio, Forni Selma, Misztal Ignacy   +2 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

The genomic anchors of the human major histocompatibility complex [PDF]

, 2009
Eukaryotic chromatin is organised into a hierarchy of topologically constrained loop structures. Matrix Attachment Regions (MARs) are genomic sequences that mediate the anchoring of chromatin to the insoluble proteinaceous fraction of the nucleus known
Ottaviani, D., Ottaviani, D
core