Results 231 to 240 of about 3,072,702 (307)

Retinoic acid-induced 2 deficiency impairs genomic stability in breast cancer. [PDF]

Breast Cancer Res
Boettcher L, Greimeier S, Borgmann K, Mughal SS, Ellinger B, Bartkowiak K, Zobiak B, Failla AV, Steffen P, Claus E, Besler K, Buccitelli C, Schaaf V, Ozga AK, Parretta S, Schneegans S, Mansour WY, Korbel JO, Schlueter H, Brors B, Pantel K, Wikman H, Werner S.   +22 more
europepmc   +1 more source

Manifesto, Turkey as model and a debate on ritual slaughtering - highlights of the Dutch debate first quarter 2011 / European Stability Initiative

, 2011
unknown
core   +1 more source

Deep Contrastive Learning for High‐Throughput Prediction of Drug Resistance Mutations from Sequences

Advanced Science, EarlyView.
This study presents DeepMutDTA, a deep learning framework aimed at predicting mutation‐induced changes in protein‐drug interactions and prioritizing variants potentially linked to drug resistance. Trained on large‐scale data, it incorporates SimSiam‐MuTF, a label‐aware contrastive fine‐tuning strategy that encourages separation between WT and MT ...
Xiaowen Hu, Pan Zhang, Shangqian Wu, Hao Sun, Minwei Li, Sophia Tsoka, Zizhang Sheng, Lei Deng   +7 more
wiley   +1 more source

Optimized derivation and culture system of human naïve pluripotent stem cells with enhanced DNA methylation status and genomic stability. [PDF]

Protein Cell
Bi Y, Hu J, Wu T, Ouyang Z, Lin T, Sun J, Zhang X, Xu X, Wang H, Wei K, Gao S, Wang Y.   +11 more
europepmc   +1 more source

Integrating Genetics With Epidemiological Measurements Identifies Burden QTLs of Inflammatory Bowel Disease across 20 Countries

Advanced Science, EarlyView.
The burden quantitative trait locus (bQTL) analysis integrates epidemiological data from GBD study with genotype of 2 621 978 SNPs from 2414 individuals in 1000 Genomes Project across 20 countries. rs7633471 shows the strongest effect that each increase in centi‐allele frequency of the allele C associated with 10.00 decrease of age‐standardized ...
Chen Sun, Siyu Wei, Junxian Tao, Haiyan Chen, Chi Yan, Jiacheng Wang, Jing Xu, Lian Duan, Yuanbo Zhan, Yuping Zou, Ruilin Li, Linna Yuan, Wei She, Songlin Lu, Ning Wang, Qinduo Ren, Yan Guo, Yuan Xu, Chang Wang, Hongsheng Tian, Chen Zhang, Yu Dong, Guoping Tang, Zhenwei Shang, Yongshuai Jiang, Wenhua Lv, Mingming Zhang, Hongchao Lyu   +27 more
wiley   +1 more source

Phase separation in DNA repair: orchestrating the cellular response to genomic stability. [PDF]

PeerJ
Deng J, Du Z, Li L, Zhu M, Zhao H.
europepmc   +1 more source

Attomolar Detection of HIV‐1 With Label‐Free RCA‐rCRISPR on Smartphone

Advanced Science, EarlyView.
A new diagnostic strategy integrating rolling circle amplification (RCA) with a plasmid reporter–based ratiometric CRISPR (rCRISPR) system was developed to detect unfragmented HIV genomes with single‐digit attomolar sensitivity. The method quantifies targets using the plasmid relaxation ratio and employs a smartphone‐based mini‐gel device to enable ...
Noor Mohammad, Anastasiia Steksova, Yuyang Tang, Leyao Huang, Alireza Velayati, Shengwei Zhang, Aditi Dey Poonam, Sina Jamalzadegan, Matthew Breen, Hongjie Chen, Mahsa Bagi, Guochun Jiang, Qingshan Wei   +12 more
wiley   +1 more source

Genomic Size Is Critical to Guarantee the Genomic Stability of Non-Replicative HSV1 Vectors. [PDF]

Int J Mol Sci
Basset J, Seraffin A, Ratelade J, Dickx Y, Benedyk T, Sarek G, Jégu T, Epstein AL.   +7 more
europepmc   +1 more source

Transcription Factor Promiscuity Drives Regulatory Rewiring and Evolvability in Gene Networks in Bacteria

Advanced Science, EarlyView.
When a master transcription factor (TF) is lost, bacteria can rapidly rewire gene regulatory networks by co‐opting related regulators. Using experimental evolution in Pseudomonas fluorescens, we show that TF promiscuity (low‐level, non‐cognate binding) provides the raw material for rewiring. Successful co‐option follows a predictable hierarchy governed
Tiffany B. Taylor, Alan M. Rice
wiley   +1 more source

Endogenous p21 levels protect genomic stability by suppressing both excess and restrained nascent DNA syntheses. [PDF]

Sci Adv
Calzetta NL, Mansilla SF, Ahlers CM, Bertolin AP, Caimi LI, Arbilla SV, Zeng J, Wiesmüller L, Gottifredi V.   +8 more
europepmc   +1 more source