Results 61 to 70 of about 3,072,702 (307)

Genomic distance under gene substitutions [PDF]

, 2011
Dias Vieira Braga M, Machado R, Ribeiro LC, Stoye J. Genomic distance under gene substitutions. BMC Bioinformatics. 2011;12(Suppl 9: Proc. of RECOMB-CG 2011): S8.Background: The distance between two genomes is often computed by comparing only the common
Stoye Jens, Braga Marília D V, Jens Stoye, Machado, Raphael, Marília D V Braga, Stoye, Jens ; https://orcid.org/, Raphael Machado, Leonardo C Ribeiro, Machado Raphael, Dias Vieira Braga, Marília, Ribeiro, Leonardo C., Ribeiro Leonardo C   +11 more
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Phosphorylation-dependent WRN-RPA interaction promotes recovery of stalled forks at secondary DNA structure

Nature Communications
The WRN protein is vital for managing perturbed replication forks. Replication Protein A strongly enhances WRN helicase activity in specific in vitro assays. However, the in vivo significance of RPA binding to WRN has largely remained unexplored.
Alessandro Noto, Pasquale Valenzisi, Flavia Di Feo, Federica Fratini, Tomasz Kulikowicz, Joshua A. Sommers, Benedetta Perdichizzi, Maurizio Semproni, Valentina Palermo, Marco Crescenzi, Robert M. Brosh Jr, Annapaola Franchitto, Pietro Pichierri   +12 more
doaj   +1 more source

Chromatin Movement in the Maintenance of Genome Stability [PDF]

Cell, 2013
Mechanistic analyses based on improved imaging techniques have begun to explore the biological implications of chromatin movement within the nucleus. Studies in both prokaryotes and eukaryotes have shed light on what regulates the mobility of DNA over long distances.
Dion V, Gasser SM
openaire   +3 more sources

Noah's dove returns: Armenia, Turkey and the debate on genocide / European Stability Initiative

, 2009
Parallel als Buch-Ausg ...
unknown
core   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Meeting report : 1st international functional metagenomics workshop May 7–8, 2012, St. Jacobs, Ontario, Canada [PDF]

, 2012
This report summarizes the events of the 1st International Functional Metagenomics Workshop. The workshop was held on May 7 and 8 in St. Jacobs, Ontario, Canada and was focused on building a core international functional metagenomics community, exploring
David R. Rose, Charles, Trevor, Valla, Svein, Reid, Alexandra, Kornelia Smalla, John Doemer, Edwards, Elizabeth A., Smalla, K., Alexandra Reid, Katja Engel, Moreno-Hagelsieb, Gabriel, Charles, Trevor C., Cheng-Cang Wu, Trevor C. Charles, Reid, A., Sean F. Brady, Sjöling, Sara, Liles, Mark R., Brady, Sean F., Sara Sjöling, Sjöling, Sara,, David A. Mead, Eric C. Martens, O’gara, Fergal, Streit, Wolfgang R., Sessitsch, Angela, Wellington, Elizabeth M.H., Edwards, E. A., Simonet, Pascal, Jennifer Tedman-Jones, O’Gara, F., Neufeld, Joseph D., Wolfgang R. Streit, Ashby, Deborah, Elizabeth A. Edwards, Wu, Cheng-Cang, Wellington, Elizabeth, Neufeld, Josh D., Fiebig, Klaus, Tedman-Jones, Jennifer, Martens, Erik C., Martens, Eric C., Angela Sessitsch, Engel, Katja, Doemer, John, Fergal O’Gara, Cowan, Don A., Miyazaki, Kentaro, Klaus Fiebig, Elizabeth M. H. Wellington, Pascal Simonet, Don A. Cowan, Rose, David R., Mark R. Liles, Smalla, Kornelia, Josh D. Neufeld, Wellington, Elizabeth M. H., Svein Valla, Kentaro Miyazaki, Gabriel Moreno-Hagelsieb, Deborah Ashby, Dennis McCormac, Wellington, E. M. H., McCormac, Dennis, O'Gara, Fergal, Mead, David A.   +65 more
core   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source