Results 161 to 170 of about 358,877 (267)

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

A Cryoprotectant‐Compatible Nanoporous Platform for Stable and Scalable Delivery of Biopharmaceuticals

Advanced Materials, EarlyView.
A cryoprotectant‐compatible nanoporous platform enables ambient‐stable and scalable delivery of gene editing therapeutics. By combining hierarchical pore architecture with optimized lyophilization chemistry, the system preserves Cas9‐RNP activity post‐freeze‐drying.
Sian Lee, Seongchan Kim, Jooyeun Chong, Min‐gyeong Kim, Kayeong Lim, Nan‐Ee Lee, Jahyun Koo, Jiheong Kang, Hyojin Lee   +8 more
wiley   +1 more source

Genomic structural variation underlies cell type-specific betacyanin variegation in Chenopodium quinoa. [PDF]

Stress Biol
Zhang Z, Wang Y, Hu X, Yu T, Feng Y, Zhang J, Zhang T, Feng G, Zhang H.   +8 more
europepmc   +1 more source

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

Advanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode, Christian Ortiz, Tadeh Derstepanian, Natalia Vargas‐Montoya, Priyal Patel, Nikita Khadse, Saikat Manna, Ryan Landis, Joseph Skaleski, Lianne Boeglin, Hongfeng Deng, Anusha Dias, Hong Wang, Debora Barreiros Petropolis, Barak Yahalom, Shrirang Karve, Frank DeRosa   +16 more
wiley   +1 more source

Identification of candidate genes for reproductive traits in Xinjiang sheep breeds based on genomic structural variation. [PDF]

Front Vet Sci
Li J, Yiming S, Zheng W, Wu W, Bi J, Li F, Zhu M.   +6 more
europepmc   +1 more source

Recurring genomic structural variation leads to clonal instability and loss of productivity. [PDF]

Biotechnol Bioeng, 2019
Bandyopadhyay AA, O'Brien SA, Zhao L, Fu HY, Vishwanathan N, Hu WS.   +5 more
europepmc   +1 more source

Machine Learning‐Informed Nano Co‐Assembly Inhibits Fibroblast Activation Protein and Improves Drug Delivery in Fibrotic Tissue

Advanced Materials, EarlyView.
We present SP‐13786 (SP), a fibroblast activation protein (FAP) inhibitor, as a universal excipient for co‐assembling stable drug nanoparticles (SCAN). Assembly mechanism deciphered by molecular dynamics and explainable machine learning, SCAN attenuate fibrosis‐induced stromal barriers, enhances lesional drug accumulation, and improves therapeutic ...
Zehua Liu, Qiang Long, Yihao Liu, Xiuqiao Sun, Baoding Zhang, Binxin Liao, Weibin Wu, Wangxi Hai, Pei Zhang, Wenhua Lian, Yuewen Zhu, Zheng Wang, Caisheng Wu, Xianming Deng, Hélder A. Santos, Xiaofeng Ye   +15 more
wiley   +1 more source

Novel CFHR2-CFHR1 Hybrid in C3 Glomerulopathy Identified by Genomic Structural Variation Analysis. [PDF]

Kidney Int Rep, 2019
Sugawara Y, Kato H, Yoshida Y, Fujisawa M, Kokame K, Miyata T, Akioka Y, Miura K, Hattori M, Nangaku M.   +9 more
europepmc   +1 more source

Public data archives for genomic structural variation [PDF]

Nature Genetics, 2010
Deanna M, Church, Ilkka, Lappalainen, Tam P, Sneddon, Jonathan, Hinton, Michael, Maguire, John, Lopez, John, Garner, Justin, Paschall, Michael, DiCuccio, Eugene, Yaschenko, Stephen W, Scherer, Lars, Feuk, Paul, Flicek   +12 more
openaire   +2 more sources

Genome-wide structural variation in poplar

, 2011
Background: In the last few years, researchers realized that single nucleotide polymorphisms (SNPs) identified by genome wide association scans explained only a small proportion of the heritability of complex and quantitative traits. Several authors suggested that a substantial part of the missing heritability might reside in structural variants, such ...
Pinosio, Sara, Marroni, Fabio, Jorge, Véronique, Faivre-Rampant, Patricia, Felice, Nicoletta, Di Centa, Eleonora, Bastien, Catherine, Cattonaro, Federica, Morgante, Michele   +8 more
openaire   +2 more sources