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Genomic structural variation in psychiatric disorders
Development and Psychopathology, 2012AbstractCopy number variants (CNVs) are submicroscopic deletions and duplications of genomic material that were previously thought to be rare phenomena. They have now been robustly associated with a variety of disorders such as autism, schizophrenia, and attention-deficit/hyperactivity disorder through an emerging research base in affective disorders ...
Rucker, James, McGuffin, Peter
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Resolving genomic structural variation
Science, 2021Human Genomics Many human genomes have been reported using short-read technology, but it is difficult to resolve structural variants (SVs) using these data. These genomes thus lack comprehensive comparisons among individuals and populations. Ebert et al.
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[Structural variation in the human genome].
Yi chuan = Hereditas, 2009Genomic structural variation is generally defined as deletions, insertions, duplications, inversions, translocations or copy number variation (CNV) in large DNA segments (>1 kb). The structural variation in an individual genome includes thousands of discrete regions, spans millions of base pairs, and encompasses numerous entire genes and their ...
Yong-Shu, He +2 more
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Structural variation: the genome's hidden architecture
Nature Methods, 2012Next-generation sequencing is uncovering more variants than ever before, but it also faces limitations.
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Structural variations in Vicia faba mitochondrial genome
Theoretical and Applied Genetics, 1988A comparative analysis of the presence of minicircular DNA CCCIB in 16 different lines and cultivars of fertile Vicia faba L. plants was conducted. It was found that copy number of CCCIB ranged from several copies per mitochondrial genome to - probably - zero, depending on cultivar or line. Fertility of plants in these cases was not altered.
V I, Negruk, N K, Kaushik
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Structural Variation and the Soybean Genome
2017Genomic structural variation is an important component to genetic diversity in soybean (Glycine max). These large-scale genomic differences are now known as the underlying genetic mechanisms for a number of important phenotypic traits. Identifying structural variants across numerous individuals at higher resolution is increasingly possible with a ...
Justin E. Anderson, Robert M. Stupar
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Genome Structure, Organization, and Variation
2017This chapter covers the structure of the genome and the variation in genome organization found in different species, which are both the outcome of, and the ingredients for, natural selection. It discusses the structure of chromosomes, extrachromosomal DNA, changes in the genome, and integration of genomic findings with evolutionary and genetic ...
Philip Meneely +4 more
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Developmental psychopathology: The role of structural variation in the genome
Development and Psychopathology, 2012AbstractA wide range of developmental disorders present with characteristic psychopathologies and behaviors, with diagnoses including, inter alia, cognitive disorders and learning disabilities, epilepsies, autism, and schizophrenia. Each, to varying extent, has a genetic component to etiology and is associated with cytogenetic abnormalities ...
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Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer
Cell, 2018Paul Lloyd, Rahul Aggarwal, Adam Foye
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