Results 61 to 70 of about 363,020 (279)
Pediatric Blood &Cancer, EarlyView.ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider +4 more
wiley +1 more source
Complex genomic rearrangements at the PLP1 locus include triplication and quadruplication. [PDF]
PLoS Genetics, 2015 Inverted repeats (IRs) can facilitate structural variation as crucibles of genomic rearrangement. Complex duplication-inverted triplication-duplication (DUP-TRP/INV-DUP) rearrangements that contain breakpoint junctions within IRs have been recently ...
Christine R Beck +12 more
doaj +1 more source
Inter‐varietal structural variation in grapevine genomes [PDF]
The Plant Journal, 2016 SummaryGrapevine (Vitis vinifera L.) is one of the world's most important crop plants, which is of large economic value for fruit and wine production. There is much interest in identifying genomic variations and their functional effects on inter‐varietal, phenotypic differences.
CARDONE, MARIA FRANCESCA +11 more
openaire +7 more sources
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Discovery and population genomics of structural variation in a songbird genus
Nature Communications, 2020 Structural genomic variation can fuel evolution. Here, authors present genome data from seven Corvus species and unearth structural variants that vary between incipient crow species in Europe, with implications for premating isolation involving plumage ...
Matthias H. Weissensteiner +11 more
doaj +1 more source
The Plant Genome, 2021 Positional‐based cloning is a foundational method for understanding the genes and gene networks that control valuable agronomic traits such as grain yield components.
Ella Taagen +3 more
doaj +1 more source
Biological Significance of the Genomic Variation and Structural Dynamics of SARS-CoV-2 B.1.617
Frontiers in Microbiology, 2021 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants have been emerging and circulating globally since the start of the COVID-19 pandemic, of which B.1.617 lineage that was first reported in India at the end of 2020, soon became ...
Lin-qian Fan +7 more
doaj +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
SVIM: Structural Variant Identification using Mapped Long Reads
, 2019 Motivation: Structural variants are defined as genomic variants larger than 50bp. They have been shown to affect more bases in any given genome than SNPs or small indels. Additionally, they have great impact on human phenotype and diversity and have been
Heller, D., Vingron, M.
core +1 more source
Evolutionary biology for the 21st century [PDF]
, 2013 New theoretical and conceptual frameworks are required for evolutionary biology to capitalize on the wealth of data now becoming available from the study of genomes, phenotypes, and organisms - including humans - in their natural environments.Molecular ...
Arnold, Stevan J. +14 more
core +5 more sources