Results 151 to 160 of about 1,577,423 (359)

Ten Years of Landscape Genomics: Challenges and Opportunities

Frontiers in Plant Science, 2017
Landscape genomics is a relatively new discipline that aims to reveal the relationship between adaptive genetic imprints in genomes and environmental heterogeneity among natural populations. Although the interest in landscape genomics has increased since
Yong Li, Xue-Xia Zhang, Run-Li Mao, Jie Yang, Cai-Yun Miao, Zhuo Li, Ying-Xiong Qiu   +6 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Genomics in the UK: mapping the social science landscape

, 2006
This paper has been prepared from the perspective of the ESRC Genomics Policy & Research Forum, which has the particular mandate of linking social science research on genomics with ongoing public and policy debates.
Suk, Jonathan E., Banner, Michael
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

GENOMICS IN ASIA: A CLASH OF BIOETHICAL INTERESTS?

, 2004
Contents -- Acknowledgements -- Introduction -- Ch. 1. Genomics in Asia: cultural values and bioethical practices / Margaret Sleeboom -- Pt. I. Religious perspectives -- Ch. 2. Ethical issues: an Islamic perspective / Anwar Nasim -- Ch. 3.
Sleeboom, Margaret, ed.
core  

Psychiatric Genomics: An Update and an Agenda

bioRxiv, 2017
The Psychiatric Genomics Consortium (PGC) is the largest consortium in the history of psychiatry. In the past decade, this global effort has delivered a rapidly increasing flow of new knowledge about the fundamental basis of common psychiatric disorders,
P. Sullivan, A. Agrawal, C. Bulik, O. Andreassen, A. Børglum, G. Breen, S. Cichon, H. Edenberg, S. Faraone, J. Gelernter, C. Mathews, C. Nievergelt, J. Smoller, M. O’Donovan   +13 more
semanticscholar   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Responsible genomes: How can we foster responsible innovation in synthetic genomics?

Journal of Responsible Innovation
Reflections on the responsible development of synthetic genomics have contributed to shaping Responsible Research and Innovation (RRI) as an area of inquiry.
Paolo Corsico, Philip Shapira
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Surges and insights from the genomics of insect pests

Genomics Communications
Genomics has revolutionized our understanding of agricultural insects by revealing the genetic basis of their adaptation, pesticide resistance, and ecological success, while also driving the development of sustainable pest management innovations ...
Alexander Yesaya, Lei Zhang, Yan Peng, Yutao Xiao   +3 more
doaj   +1 more source