KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells
Molecular Oncology, EarlyView.We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock +10 more
wiley +1 more source
Ultraconserved Sequences in the Honeybee Genome - Are GC-rich Regions Preferred? [PDF]
Systemix Reports 2, Feb. 18 (2007), 2007 Among all insect genomes, honeybee displays one of the most unusual patterns with interspersed long AT and GC-rich segments. Nearly 75% of the protein-coding genes are located in the AT-rich segments of the genome, but the biological significance of the GC-rich regions is not well understood.
arxiv
The Genomic Complexity of Acanthamoeba castellanii Mitochondrial DNA [PDF]
, 1974 Hans J. Bohnert, Reinhold G. Herrmann
openalex +1 more source
The genome incorporated: constructing biodigital identity [PDF]
, 2010 The Genome Incorporated examines the proliferation of human genomics across contemporary media cultures. It explores questions about what it means for a technoscience to thoroughly saturate everyday life, and places the interrogation of the science/media
O'Riordan, Kate
core +1 more source
Molecular Oncology, EarlyView.Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy +12 more
wiley +1 more source
Streptomycin biosynthesis in Streptomyces griseus II. Adjacent genomic location of biosynthetic genes and one of two streptomycin resistance genes [PDF]
, 1985 J Distler
openalex +2 more sources
A Compressed Self-Index for Genomic Databases [PDF]
arXiv, 2011 Advances in DNA sequencing technology will soon result in databases of thousands of genomes. Within a species, individuals' genomes are almost exact copies of each other; e.g., any two human genomes are 99.9% the same. Relative Lempel-Ziv (RLZ) compression takes advantage of this property: it stores the first genome uncompressed or as an FM-index, then
arxiv
Methylation pattern of genomic RNA from Moloney murine leukemia virus [PDF]
, 1976 Maurice C. Bondurant +2 more
openalex +1 more source
Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer
Molecular Oncology, EarlyView.mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia +17 more
wiley +1 more source
Deep Learning of radiology-genomics integration for computational oncology: A mini review
Computational and Structural Biotechnology JournalIn the field of computational oncology, patient status is often assessed using radiology-genomics, which includes two key technologies and data, such as radiology and genomics.
Feng-ao Wang, Yixue Li, Tao Zeng
doaj